Patent EP0318183A2 successfully refreshed from Google Patents.
EP0318183A2
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EP
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Pressure-sensitive medical sealant
Assignee: 3M Co
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Filing: 1988-11-10
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Granted: —
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Expires: 2008-11-10
Abstract
Abstract A pressure sensitive medical sealant composition comprising a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; b) a plasticizer; and c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.
Inventors
- 👤 Robert A. C/O Minnesota Mining And Asmus
- 👤 Daniel C. C/O Minnesota Mining And Duan
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 09:15
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61L24/00; A61L24/001; A61L24/0015; A61L24/04; A61L24/06; A61L2300/00; A61L2300/10; A61L2300/106; A61L2300/40; A61L2300/404; A61L2300/406; Y; Y10; Y10S; Y10S526/00; Y10S526/931
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
84 words
A medical sealant composition comprising: (a) a crosslinked, swellable polymeric matrix formed by a free-radical polymerization of at least one polymerizable monomeric species wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams; (b) a plasticizing solution; and (c) an antimicrobial; characterized in that said polymeric matrix has been crosslinked with a crosslinker which is a multi-ethylenically unsaturated compound with the ethylenic groups being vinyl, allyl, or methallyl groups bonded to nitrogen or oxygen atoms.
Claim 2
Dependent Claim
84 words
A medical sealant composition comprising: (a) a crosslinked, swellable polymeric matrix formed by a free-radical polymerization of at least one polymerizable monomeric species wherein at least 50 percent by weight of the monomeric component is comprised of one or more N-vinyl lactams; (b) a plasticizing solution; and (c) an antimicrobial; characterized in that said polymeric matrix has been crosslinked with a crosslinker which is a multi-ethylenically unsaturated compound with the ethylenic groups being vinyl, allyl, or methallyl groups bonded to nitrogen or oxygen atoms.
Claim 3
Dependent Claim
43 words
A composition in accordance with Claim 1 further characterized in that said multi-ethylenically unsaturated compound is selected from the group consisting of divinyl, diallyl and dimethallyl esters; divinyl, diallyl and dimethallyl amides; divinyl, diallyl and dimethallyl ethers; and divinyl, diallyl and dimethallyl ureas.
Claim 4
Dependent Claim
17 words
A composition in accordance with Claim 1 further characterized in that the N-vinyl lactam monomer is N-vinyl-2-pyrrolidone.
Claim 5
Dependent Claim
32 words
A composition in accordance with Claim 1 further characterized in that said antimicrobial is selected from the group consisting of iodine, chlorhexidine gluconate, parachlorometaxylenol, zinc bacitracin, neomycin sulfate and polymyxin B sulfate.
Claim 6
Dependent Claim
46 words
A polymerizable composition comprising an N-vinyl lactam monomer, a plasticizer, an antimicrobial and a free radical initiator, characterized in that said composition further comprises a multi-ethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms.
Claim 7
Dependent Claim
46 words
A polymerizable composition comprising an N-vinyl lactam monomer, a plasticizer, an antimicrobial and a free radical initiator, characterized in that said composition further comprises a multi-ethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms.
Claim 8
Dependent Claim
108 words
A composition in accordance with Claim 5 further characterized in that the N-vinyl lactam monomer is present in an amount of 20 to 40 percent by weight of the composition, the plasticizer is a mixture of glycerol and water, which mixture is present in an amount from 55 to 80 percent by weight of the composition, the multi-ethylenically unsaturated compound is present in an amount of from 0.02 to 5.0 percent by weight of the N-vinyl lactam monomer, and the free radical initiator is a photoinitiator which is present in an amount of from 0.02 percent to 2 percent by weight of the polymerizable components of the composition.
Claim 9
Dependent Claim
123 words
A method of preparing a medical sealant composition in accordance with Claim 1, comprising the steps of (a) preparing a composition comprising an N-vinyl lactam monomer and a crosslinker; and (b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix; further characterized by the feature that said crosslinker is a multi-ethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms; and further characterized by the feature that the method also comprises the steps of (c) grinding said polymer into a powder having an average particle size of less than 0.25 cm; and (d) adding said powder to a plasticizer solution having an antimicrobial therein.
Claim 10
Dependent Claim
120 words
A method of preparing a medical sealant composition in accordance with Claim 1, comprising the steps of (a) preparing a composition comprising an N-vinyl lactam monomer, a crosslinker, and an antimicrobial; (b) exposing said composition to sufficient energy to result in the formation of a crosslinked swellable polymeric matrix; further characterized by the feature that said crosslinker is a multi-ethylenically unsaturated compound wherein the ethylenic groups are vinyl groups, allyl groups, or methallyl groups bonded to nitrogen or oxygen atoms, and further characterized by the feature that the method also comprises the steps of (c) grinding said polymer into a powder having an average particle size of less than 0.25 cm; and (d) adding said powder to a plasticizer solution.
Claim 11
Dependent Claim
88 words
A caulkable medical sealant prepared according to the method of Claims 7 or 8 further characterized by the features that the amount of said N-vinyl lactam monomer is 5 to 65 percent by weight of said sealant composition, the amount of said multi-ethylenically unsaturated compound is 0.02 to 5.0 percent by weight of said monomer, the amount of said plasticizer is 35 to 95 percent by weight of said sealant composition, and the amount of said antimicrobial is 0.01 to 10.0 percent by weight of said sealant composition.
References Cited (Backward Citations)
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