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EP0336901A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Anesthetic skin moisturizing composition and method of preparing same

Assignee: Warner Lambert Co LLC
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Filing: 1989-04-03
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Granted: —
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Expires: 2009-04-03
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Abstract

Abstract A long lasting, esthetically pleasing medicated skin care moisturizing composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent having an HLB number of about 7 to about 12, wherein the non-ionic surface active agent is present in an amount of about 5% to about 9%; (2) an aqueous phase comprising an aqueous thickening agent from about 0.05% to about 5% and water from about 15% to about 65%; (3) an effective amount of a topical medicament; wherein the oil phase is added to the aqueous phase to form an emulsion and a topical medicament admixed into the emulsion has been developed. The method of preparation of the composition and a method of treating skin with the composition are also disclosed.

Inventors

  • 👤 Navin Manohar Geria

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-24 13:08
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/04; A61K8/06; A61K9/00; A61K9/0012; A61K9/0014; A61K31/00; A61K31/33; A61K31/395; A61K31/535; A61K8/18; A61K8/30; A61K8/33; A61K8/39; A61K8/63; A61K8/72; A61K8/81; A61K8/8141; A61K8/8147; A61K8/84; A61K8/86; A61K8/92; A61Q; A61Q19/00; A61Q19/007

Claims Analysis

Total Claims: 22
Claim 1
Independent Claim 103 words
A medicated skin care composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent having an HLB number of about 7 to about 12, wherein the non-ionic surface active agent is present in an amount of about 5% to about 9%; (2) an aqueous phase comprising an aqueous thickening agent from about 0.05% to about 5% and water from about 15% to about 65% and (3) an effective amount of a medicament, wherein the medicament is not a corticosteroid and the oil phase is added to the aqueous phase to form an emulsion.
Claim 2
Dependent Claim 103 words
A medicated skin care composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent having an HLB number of about 7 to about 12, wherein the non-ionic surface active agent is present in an amount of about 5% to about 9%; (2) an aqueous phase comprising an aqueous thickening agent from about 0.05% to about 5% and water from about 15% to about 65% and (3) an effective amount of a medicament, wherein the medicament is not a corticosteroid and the oil phase is added to the aqueous phase to form an emulsion.
Claim 3
Dependent Claim 108 words
A skin care composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent having an HLB number of about 7 to about 12, wherein the non-ionic surface active agent is present in an amount of about 5% to about 9%; (2) an aqueous phase comprising an aqueous thickening agent from about 0.05% to about 5% and an effective amount of a neutralizing agent, and water from about 15% to about 65%; (3) an effective amount of a medicament; wherein the medicament is not corticosteroid and the oil phase is added to the aqueous phase to form an emulsion.
Claim 4
Dependent Claim 108 words
A skin care composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent having an HLB number of about 7 to about 12, wherein the non-ionic surface active agent is present in an amount of about 5% to about 9%; (2) an aqueous phase comprising an aqueous thickening agent from about 0.05% to about 5% and an effective amount of a neutralizing agent, and water from about 15% to about 65%; (3) an effective amount of a medicament; wherein the medicament is not corticosteroid and the oil phase is added to the aqueous phase to form an emulsion.
Claim 5
Dependent Claim 28 words
The composition of Claims 1 or 2 wherein the oil is selected from the group consisting of animal oils, vegetable oils, mineral oils, synthetic oils and mixtures thereof.
Claim 6
Dependent Claim 37 words
The composition of Claims 1 or 2 wherein the oil is an animal oil selected from the group consisting of lanolin, fatty acid esters, fish oil, whale, oil, fish liver oil, seal oil, squalane and mixtures thereof.
Claim 7
Dependent Claim 63 words
The composition of Claims 1 or 2 wherein the oil is a vegetable oil selected from the group consisting of castor oil, linseed oil, sunflower oil, soybean oil, olive oil, peanut oil, rapeseed oil, corn oil, safflower seed oil, cottonseed oil, coconut oil, palm oil, palm kernel oil, sweet almond oil, calophyllum oil, avacado oil, cerial germ oil, purcellin oil, and mixtures thereof.
Claim 8
Dependent Claim 33 words
The composition of Claims 1 or 2 wherein the oil is a mineral oil preferably selected from the group consisting of white mineral oil, parafin oil, petroleum jelly oil, petrolatum and mixtures thereof.
Claim 9
Dependent Claim 31 words
The composition of Claims 1 or 2 wherein the oil is a synthetic oil selected from the group consisting of silicone oils, dimethylpolysiloxane, cyclic silicones, methylphenylpolysiloxane, silicone-glycol copolymer and mixtures thereof.
Claim 10
Dependent Claim 38 words
The composition according to anyone of the Claims 1 to 7 wherein the non-ionic surface active agent is selected from the group consisting of alkanolamides, poly­oxyethylenes, polyoxyethylene fatty acid esters, polyethylene-­glycol derivatives, polyethyleneimine derivatives, ethoxylated hydrogenated castor oils.
Claim 11
Dependent Claim 46 words
The composition according to anyone of the Claims 1 to 7 wherein the non-ionic surface active agent is selected from the group consisting of polyoxyethylene (2) stearyl ether, POE (2) oleyl ether, PPG (5) ceteth 20, POE (5) stearate, POE (20) stearyl ether and mixtures thereof.
Claim 12
Dependent Claim 32 words
The composition according to anyone of the Claims 1 to 9 wherein the aqueous thickening agent is selected from the group consisting of natural gums, synthetic gums, gelling agents and mixtures thereof.
Claim 13
Dependent Claim 45 words
The composition according to anyone of the Claims 1 to 9 wherein the aqueous thickening agent is a natural gum selected from the group consisting of alginates, carrageenan, xanthan gum, gelatin, guar, gum arabic, carob, tragacanth, locust bean gum, karaya, pectin, agar, and mixtures thereof.
Claim 14
Dependent Claim 40 words
The composition according to anyone of the Claims 1 to 9 wherein the aqueous thickening agent is a synthetic selected from the group consisting of cellulose ethers and esters, methylcellulose, sodium carboxymethyl­cellulose, carboxymethylcellulose, hydroxypropylcellulose, carbomers and carbopol and mixtures thereof.
Claim 15
Dependent Claim 36 words
The composition according to anyone of the Claims 1 to 9 wherein the aqueous thickening agent is selected from the group consisting of Colloidal hydrated aluminum silicate, bentonite, synthetic hectorite, laponite, colloidal silica and mixtures thereof.
Claim 16
Dependent Claim 30 words
The composition of Claim 2 wherein the neutralizing is selected from the group consisting of basic alkali metal salts, basic alkaline earth metal salts, basic amine compounds and mixtures thereof.
Claim 17
Dependent Claim 31 words
The composition of Claim 2 wherein the neutralizing agent is selected from the group consisting of alkali metal and alkaline earth metal hydroxides and carbonates, triethanol amine isopropylamine and mixtures thereof.
Claim 18
Dependent Claim 46 words
The composition according to anyone of the Claims 1 to 15 wherein the medicament is an anesthetic selected from the group consisting of butamben, benzocaine, tetracaine, diperodon, dibucaine, lidocaine, diphenhydramine, methapyriline, tripelennamine, dimethisoquin, dyclonine, chloroprocaine, cocaine, mepivacaine, peperocaine, prilocaine, tetracaine, pramoxine their salts and mixtures thereof.
Claim 19
Dependent Claim 17 words
The composition according to anyone of the Claims 1 to 15 wherein the medicament is pramoxine hydro­chloride.
Claim 20
Independent Claim 122 words
A method for preparing a skin car composition as claimed in anyone of the Claims 1 and 3 to 17 comprising forming an oil phase by dissolving a surface active agent into an oil and heating to facilitate solution, forming an aqueous phase by dispersing an aqueous thickening agent in water and heating to facilitate dispersing, forming an emulsion by slowly adding the oil phase to the aqueous phase with high shear mixing while maintaining an elevated temperature and admixing an effective amount of a medicament, wherein the medicament is not a corticosteroid and addition of the oil phase to the water phase is at a slow uniform rate such that a stable emulsion is formed; and recovering the skin care composition.
Claim 21
Independent Claim 135 words
A method for preparing a skin care composition as claimed in anyone of the compositions 2 to 17 comprising forming an oil phase by dissolving a surface active agent into an oil and heating to facilitate solution, forming an aqueous phase by dispersing an aqueous thickening agent requiring a neutralizing agent in water and heating to facilitate dispersing, forming an emulsion by slowly adding the oil phase to the aqueous phase with high shear mixing while maintaining an elevated temperature, admixing an effective amount of a medicament, wherein the medicament is not a corticosteroid and addition of the oil phase to the water phase is at a slow uniform rate such that a stable emulsion is formed, neutralizing the emulsion by adding an effective amount of a neutralizing agent, and recovering the skin care composition.
Claim 22
Independent Claim 29 words
A method of treating skin which comprises applying to the skin an effective amount of a skin care composition as claimed in anyone of the Claims 1 to 17.

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