Patent EP0347748A2 successfully refreshed from Google Patents.
EP0347748A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Pharmaceutical granules and tablets made therefrom
Assignee: Abbott Laboratories
•
Filing: 1989-06-15
•
Granted: —
•
Expires: 2009-06-15
Abstract
Abstract A pharmaceutical granule comprising a core of active pharmaceutical agent and a coating of a polymer/microcrystalline cellulose is provided. These granules permit superior tableting of pharmaceutical agents whose physical properties in granule form render them unsuitable for conventional tableting.
Inventors
- 👤 Dale R. Brinker
- 👤 Thomas L. Reiland
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 23:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
39 words
A composition for coating drug granules which comprises a solution of from about 0.5% to about 10% (w/v) of a polymer selected from povidone, hydroxypropyl cellulose and hydroxypropyl methylcellulose, and from about 5% to about 25% (w/v) microcrystalline cellulose.
Claim 2
Dependent Claim
39 words
A composition for coating drug granules which comprises a solution of from about 0.5% to about 10% (w/v) of a polymer selected from povidone, hydroxypropyl cellulose and hydroxypropyl methylcellulose, and from about 5% to about 25% (w/v) microcrystalline cellulose.
Claim 3
Dependent Claim
12 words
The composition of Claim 1 comprising 1% povidone and 10% microcrystalline cellulose.
Claim 4
Dependent Claim
62 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, packaging and distribution comprising a core of active drug and a surface coating comprising a polymer selected from povidone, hydroxypropyl cellulose and hydroxypropyl methylcellulose and microcrystalline cellulose, the polymer:microcrystalline cellulose ratio being from about 1:15 to about 2:1 by weight.
Claim 5
Dependent Claim
62 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, packaging and distribution comprising a core of active drug and a surface coating comprising a polymer selected from povidone, hydroxypropyl cellulose and hydroxypropyl methylcellulose and microcrystalline cellulose, the polymer:microcrystalline cellulose ratio being from about 1:15 to about 2:1 by weight.
Claim 6
Dependent Claim
12 words
The granule of Claim 3 wherein the active drug is divalproex sodium.
Claim 7
Dependent Claim
28 words
A tablet having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, packaging and distribution and comprising granules according to claim 3.
Claim 8
Dependent Claim
12 words
The tablet of claim 5 wherein the active drug is divalproex sodium.
Claim 9
Dependent Claim
18 words
The tablet of claim 5 wherein the surface coating comprises 1% (w/v) povidone and 10% (w/v) microcrystalline cellulose.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.