Patent EP0355266A2 successfully refreshed from Google Patents.
EP0355266A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Apparatus for performing repetitive chemical reactions
Assignee: EMD Millipore Corp
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Filing: 1989-04-27
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Granted: —
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Expires: 2009-04-27
Abstract
Abstract This invention relates to a system for automated chemical processing, comprising: cartridge means (12) for storing, dissolving and dispensing chemicals; transport means (11) for holding and delivering said cartridge means to a work station; reservoir means (Rn) for containing chemicals to be reacted with the chemicals in the cartridge means; fluid coupling means (16) at said work station for contacting said cartridge means (12) at said work station and establishing communication with the contents thereof; fluid conduit means (15) connected with said fluid coupling means (16) and said reservoir means (Rn) for conducting chemicals from the reservoir means to said cartridge means for reaction with the chemicals in the cartridge means; pump means (14) connected with said cartridge means to cause said chemicals from said reservoir means to flow into said cartridge means to dissolve and react with the chemicals in the cartridge means and to cause flow of the reacted chemicals from said cartridge means into said fluid conduit means; valve means (Vn) in the fluid conduit means for controlling flow through said conduit means; and automatically operated control means (18) connected with said pump means (14) and said valve means (Vn) to obtain a predetermined sequence of operation of said pump means and said valve means to control reaction of said chemicals, thereby insuring simplicity, economy and accuracy in said processing.
Inventors
- 👤 Derek Hudson
- 👤 Jordan Honig
- 👤 Ronald M. Cook
- 👤 Douglas J. Ng
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 07:51
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/04; C07K1/045; B; B01; B01J; B01J19/00; B01J19/0046; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00279; B01J2219/00281; B01J2219/00286; B01J2219/00288; B01J2219/0029; B01J2219/00497; B01J2219/005; B01J2219/0054; B01J2219/00547; B01J2219/00549; B01J2219/00583; B01J2219/0059; B01J2219/00596; B01J2219/0068; B01J2219/00686; B01J2219/00718; B01J2219/0072; B01J2219/00725; B01J2219/00731; C40; C40B; C40B40/00; C40B40/04; C40B40/10; C40B40/12; C40B60/00; C40B60/14; C40B70/00; Y; Y10; Y10T; Y10T436/00; Y10T436/11
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
206 words
A system for automated chemical processing, comprising: cartridge means for storing, dissolving and dispensing chemicals; transport means for holding and delivering said cartridge means to a work station; reservoir means for containing chemicals to be reacted with the chemicals in the cartridge means; fluid coupling means at said work station for contacting said cartridge means at said work station and establishing communication with the contents thereof; fluid conduit means connected with said fluid coupling means and said reservoir means for conducting chemicals from the reservoir means to said cartridge means for reaction with the chemicals in the cartridge means; pump means connected with said cartridge means to cause said chemicals from said reservoir means to flow into said cartridge means to dissolve and react with the chemicals in the cartridge means and to cause flow of the reacted chemicals from said cartridge means into said fluid conduit means; valve means in the fluid conduit means for controlling flow through said conduit means; and automatically operated control means connected with said pump means and said valve means to obtain a predetermined sequence of operation of said pump means and said valve means to control reaction of said chemicals, thereby insuring simplicity, economy and accuracy in said processing.
Claim 2
Independent Claim
206 words
A system for automated chemical processing, comprising: cartridge means for storing, dissolving and dispensing chemicals; transport means for holding and delivering said cartridge means to a work station; reservoir means for containing chemicals to be reacted with the chemicals in the cartridge means; fluid coupling means at said work station for contacting said cartridge means at said work station and establishing communication with the contents thereof; fluid conduit means connected with said fluid coupling means and said reservoir means for conducting chemicals from the reservoir means to said cartridge means for reaction with the chemicals in the cartridge means; pump means connected with said cartridge means to cause said chemicals from said reservoir means to flow into said cartridge means to dissolve and react with the chemicals in the cartridge means and to cause flow of the reacted chemicals from said cartridge means into said fluid conduit means; valve means in the fluid conduit means for controlling flow through said conduit means; and automatically operated control means connected with said pump means and said valve means to obtain a predetermined sequence of operation of said pump means and said valve means to control reaction of said chemicals, thereby insuring simplicity, economy and accuracy in said processing.
Claim 3
Dependent Claim
40 words
A system as claimed in Claim 1 wherein: a source of pneumatic pressure is connected with said reservoir means to pressurize the contents thereof and assist in flow of the chemicals from the reservoir means into the fluid conduit means.
Claim 4
Dependent Claim
35 words
A system as claimed in Claim 2 wherein: the system comprises a protein synthesis apparatus, and includes a reactor column connected in said fluid conduit means for receiving the reacted chemicals from the cartridge means.
Claim 5
Dependent Claim
27 words
A system as claimed in Claim 3 wherein: the control means includes a computer programmed to operated the valve means and pump means in said predetermined sequence.
Claim 6
Independent Claim
56 words
A system as claimed in any one of Claims 1-4 wherein: said pump means comprises a plunger slidably sealed in said cartridge means, and a reciprocating arm connected with said plunger to reciprocate said plunger in said cartridge means to alternately draw material into said cartridge means and then expel the material from the cartridge means.
Claim 7
Dependent Claim
48 words
A system as claimed in Claim 5 wherein: said transport means comprises a rotating carousel having means for holding and supporting said cartridge means thereon; and said control means is connected to operate said carousel in timed sequence with operation of said valve means and said pump means.
Claim 8
Dependent Claim
57 words
A system as claimed in Claim 5 wherein: said fluid coupling means includes reciprocable means movable into and out of contact with said cartridge means at said work station; and said control means is connected to operate said fluid coupling means in timed sequence with operation of said carousel means, said pump means and said valve means.
Claim 9
Dependent Claim
57 words
A system as claimed in Claim 6 wherein: said fluid coupling means includes reciprocable means movable into and out of contact with said cartridge means at said work station; and said control means is connected to operate said fluid coupling means in timed sequence with operation of said carousel means, said pump means and said valve means.
Claim 10
Dependent Claim
56 words
A system as claimed in Claim 8 wherein: sensors are positioned adjacent said carousel, said pump means and said fluid coupling means to detect the position and status thereof and in response thereto send a signal to the control means to insure operation of the carousel, pump means and fluid coupling means in proper timed sequence.
Claim 11
Dependent Claim
32 words
A system as claimed in Claim 9 wherein: the carousel comprises a disc-shaped member having a plurality of slots in a peripheral edge thereof, and a cartridge is supported in each slot.
Claim 12
Dependent Claim
79 words
A system as claimed in Claim 9 wherein: the system comprises a peptide synthesis apparatus, the chemicals in said cartridge means comprising a mixture of solid amino acid, hydroxybenzotriazole and benzotriazolyloxytris (dimethylamino) phosphonium hexafluorophosphate; the chemicals in said reservoir means include N-methylmorpholine in dimethylformamide for dissolution and activation in the chemicals in the cartridge means; and one of Pepsyn K and polystyrene solid supports are in said reactor column for coupling with the activated chemicals from the cartridge means.
Claim 13
Dependent Claim
138 words
Means for the storage, dissolution and dispensing of chemicals, comprising: a syringe-like cartridge having a hollow body for containing a chemical; said body having an open upper end and a lower end; a reciprocable plunger slidably sealed in the hollow body through the open upper end thereof; said lower end having an opening extending therethrough with an inner end of the opening in communication with the interior of said hollow body; and said lower end further having means defining a fluid coupling for connection to a fluid conduit, whereby a fluid may be drawn from said fluid conduit and into said hollow body upon outward movement of the plunger relative to the body, to admix with the chemical in the hollow body, and then expelled through the opening upon inward movement of the plunger relative to the body.
Claim 14
Dependent Claim
138 words
Means for the storage, dissolution and dispensing of chemicals, comprising: a syringe-like cartridge having a hollow body for containing a chemical; said body having an open upper end and a lower end; a reciprocable plunger slidably sealed in the hollow body through the open upper end thereof; said lower end having an opening extending therethrough with an inner end of the opening in communication with the interior of said hollow body; and said lower end further having means defining a fluid coupling for connection to a fluid conduit, whereby a fluid may be drawn from said fluid conduit and into said hollow body upon outward movement of the plunger relative to the body, to admix with the chemical in the hollow body, and then expelled through the opening upon inward movement of the plunger relative to the body.
Claim 15
Dependent Claim
33 words
A cartridge as claimed in Claim 12 wherein: a diametrically enlarged flange is formed on the outside of said body between the ends thereof for attachment of the cartridge to a support apparatus.
Claim 16
Dependent Claim
41 words
A cartridge as claimed in Claim 13 wherein: a porous member is secured in said body adjacent the lower end thereof and covering the inner end of said opening, defining a mechanical barrier to leakage of chemical from the hollow body.
Claim 17
Dependent Claim
33 words
A cartridge as claimed in Claim 14 wherein: a hermetic seal is secured over the opening through the lower end of the cartridge to prevent atmospheric contamination of chemical stored in the body.
Claim 18
Dependent Claim
23 words
A cartridge as claimed in Claim 15 wherein: the hollow body contains a quantity of solid amino acid for use in peptide synthesis.
Claim 19
Dependent Claim
95 words
A rotatable carousel for holding and advancing past a work station a plurality of cartridges containing chemicals to be dissolved, reacted and dispensed into a fluid system, wherein the cartridges have an exterior flange thereon, said carousel comprising: a top plate having a peripheral edge with a plurality of radially extending slots therein; and a bottom plate secured beneath the top plate to clamp between the top and bottom plates the flange of a cartridge received in a slot in the top plate, whereby said cartridge is supported in an upright position by the carousel.
Claim 20
Dependent Claim
95 words
A rotatable carousel for holding and advancing past a work station a plurality of cartridges containing chemicals to be dissolved, reacted and dispensed into a fluid system, wherein the cartridges have an exterior flange thereon, said carousel comprising: a top plate having a peripheral edge with a plurality of radially extending slots therein; and a bottom plate secured beneath the top plate to clamp between the top and bottom plates the flange of a cartridge received in a slot in the top plate, whereby said cartridge is supported in an upright position by the carousel.
Claim 21
Dependent Claim
25 words
A carousel as claimed in Claim 17 wherein: the bottom plate comprises a spring plate resiliently yieldably biased against the underside of the top plate.
Claim 22
Dependent Claim
178 words
Apparatus for holding and advancing past a work station chemicals to be dissolved, reacted and dispensed, comprising: syringe-like cartridge means having a hollow body for storing chemicals therein, said cartridge means having an open upper end and a lower end; a reciprocable plunger slidably sealed in said hollow body through the open upper end thereof, said plunger having gripping means on an outer free end projecting beyond the open end of the body whereby the plunger may be gripped and reciprocated in the body to function as a pump; gripper means at said work station for gripping said gripping means on the plunger to reciprocate the plunger inwardly and outwardly relative to the body; rotatable carousel means having means for holding and supporting a plurality of said cartridge means; fluid coupling means at said work station for engaging the cartridge means at said work station to establish fluid communication with the contents thereof; and control means for indexing said carousel past said work station in timed sequence with operation of the gripper means and the fluid coupling means.
Claim 23
Dependent Claim
178 words
Apparatus for holding and advancing past a work station chemicals to be dissolved, reacted and dispensed, comprising: syringe-like cartridge means having a hollow body for storing chemicals therein, said cartridge means having an open upper end and a lower end; a reciprocable plunger slidably sealed in said hollow body through the open upper end thereof, said plunger having gripping means on an outer free end projecting beyond the open end of the body whereby the plunger may be gripped and reciprocated in the body to function as a pump; gripper means at said work station for gripping said gripping means on the plunger to reciprocate the plunger inwardly and outwardly relative to the body; rotatable carousel means having means for holding and supporting a plurality of said cartridge means; fluid coupling means at said work station for engaging the cartridge means at said work station to establish fluid communication with the contents thereof; and control means for indexing said carousel past said work station in timed sequence with operation of the gripper means and the fluid coupling means.
Claim 24
Dependent Claim
120 words
A reactor column for holding solid supports used in chemical synthesis, comprising: a molded body of material inert to chemicals being handled in the column, said body including an elongate inlet portion having opposite open ends, and an elongate outlet portion having opposite open ends, said inlet and outlet portions being releasably snap-fitted together at one of their ends in coaxial relationship with one another, a block of porous material secured in the other end of each of the inlet and outlet portions to provide a mechanical barrier to leakage of solid material from the column, and means on each of the other ends of the inlet and outlet portions for connection of the column to a fluid delivery system.
Claim 25
Dependent Claim
120 words
A reactor column for holding solid supports used in chemical synthesis, comprising: a molded body of material inert to chemicals being handled in the column, said body including an elongate inlet portion having opposite open ends, and an elongate outlet portion having opposite open ends, said inlet and outlet portions being releasably snap-fitted together at one of their ends in coaxial relationship with one another, a block of porous material secured in the other end of each of the inlet and outlet portions to provide a mechanical barrier to leakage of solid material from the column, and means on each of the other ends of the inlet and outlet portions for connection of the column to a fluid delivery system.
References Cited (Backward Citations)
No citation records indexed.
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