Patent EP0368481A2 successfully refreshed from Google Patents.
EP0368481A2
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Immobilized fluorophores for oxygen sensors
Assignee: Smiths Medical ASD Inc
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Filing: 1989-10-12
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Granted: —
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Expires: 2009-10-12
Abstract
Abstract The present invention relates to new fluorophore compounds that are permanently covalently immobilizable in a gas-permeable support material and which are useful in the continuous measurement of blood-oxygen concentrations. The compounds comprise polycyclic aromatic hydrocarbons, or substituted derivatives thereof, with cross-linking groups thereon.
Inventors
- 👤 Robert C. Davis
- 👤 Richard A. Markle
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 22:33
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N21/643; C; C07; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/0834; C07F7/0892; C07F7/10; C07F7/18; C07F7/1804; C07F7/1896; C08; C08K; C08K5/00; C08K5/54
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
51 words
A fluorophore compound comprising: a fluorescing polycyclic aromatic hydrocarbon or substituted derivative thereof having a cross-linking group, said cross-linking group for permanently covalently bonding the fluorophore compound to a cross-linkable polymer which is a gas permeable support material, said fluorescing hydrocarbon for sensing the presence of a gas upon light excitation.
Claim 2
Dependent Claim
51 words
A fluorophore compound comprising: a fluorescing polycyclic aromatic hydrocarbon or substituted derivative thereof having a cross-linking group, said cross-linking group for permanently covalently bonding the fluorophore compound to a cross-linkable polymer which is a gas permeable support material, said fluorescing hydrocarbon for sensing the presence of a gas upon light excitation.
Claim 3
Dependent Claim
18 words
A fluorophore compound as recited in claim 1 wherein said cross-linking group contains at least one silicon atom.
Claim 4
Dependent Claim
56 words
A fluorophore compound as recited in claim 1 wherein said cross-linking group is selected from a group consisting of: -SI(NR˝₂)₃, and -SI( R˝)₃, wherein R˝ is selected from a group consisting of alkyl, cycloalkyl or halogenated derivatives thereof, with the proviso that the halogen is not bonded to a carbon atom alpha in a carbonyl group.
Claim 5
Dependent Claim
14 words
A fluorophore compound as recited in claim 3 wherein R˝ is methyl or ethyl.
Claim 6
Dependent Claim
27 words
A fluorophore compound as recited in claim 1 wherein said fluorescing hydrocarbon is selected from a group consisting of fluoranthene, coronene and decacyclene, or substituted derivatives thereof.
Claim 7
Dependent Claim
19 words
A fluorophore compound as recited in claim 1 wherein said fluorescing hydrocarbon is pyrene or a substituted derivative thereof.
Claim 8
Dependent Claim
80 words
A fluorophore compound as recited in claim 1 having the structure wherein said fluorescing hydrocarbon is selected from a group consisting of pyrene, decacyclene, coronene and fluoranthene, or substituted derivatives thereof, and said cross-linking group and is selected from a group consisting of: -SI(NR˝₂)₃, and -SI( R˝)₃, wherein R˝ is selected from a group consisting of alkyl, cycloalkyl or halogenated derivatives thereof, with the proviso that the halogen is not bonded to a carbon atom alpha in a carbonyl group.
Claim 9
Dependent Claim
14 words
A fluorophore compound as recited in claim 7 wherein R˝ is methyl or ethyl.
Claim 10
Dependent Claim
11 words
A fluorophore compound as recited in claim 7 having the structure:
Claim 11
Dependent Claim
70 words
A sensor for sensing blood gases comprising: a cross-linkable polymer support material which is permeable to a gas and a fluorophore compound permanently covalently bonded within said support material, said fluorophore compound comprising a fluorescing polycyclic aromatic hydrocarbon or substituted derivative thereof having a cross-linking group for permanently covalently bonding said fluorophore compound within said support material, said fluorescing hydrocarbon for sensing the presence of a gas upon light excitation.
Claim 12
Dependent Claim
70 words
A sensor for sensing blood gases comprising: a cross-linkable polymer support material which is permeable to a gas and a fluorophore compound permanently covalently bonded within said support material, said fluorophore compound comprising a fluorescing polycyclic aromatic hydrocarbon or substituted derivative thereof having a cross-linking group for permanently covalently bonding said fluorophore compound within said support material, said fluorescing hydrocarbon for sensing the presence of a gas upon light excitation.
Claim 13
Dependent Claim
14 words
A sensor as recited in claim 10 wherein said support material is silicone rubber.
Claim 14
Dependent Claim
17 words
A sensor as recited in claim 10 wherein said cross-linking group contains at least one silicon atom.
Claim 15
Dependent Claim
55 words
A sensor as recited in claim 10 wherein said cross-linking group is selected from a group consisting of: -SI(NR˝₂)₃, and -SI( R˝)₃, wherein R˝ is selected from a group consisting of alkyl, cycloalkyl or halogenated derivatives thereof, with the proviso that the halogen is not bonded to a carbon atom alpha in a carbonyl group.
Claim 16
Dependent Claim
13 words
A sensor as recited in claim 10 wherein R˝ is methyl or ethyl.
Claim 17
Dependent Claim
27 words
A sensor as recited in claim 10 wherein said fluorescing hydrocarbon is selected from a group consisting of pyrene, fluoranthene, coronene and decacyclene, or substituted derivatives thereof.
Claim 18
Dependent Claim
83 words
A sensor as recited in claim 10 wherein said fluorophore compound has the structure wherein said fluorescing hydrocarbon is selected from a group consisting of pyrene, decacyclene, coronene and fluoranthene, or substituted derivatives thereof, and said cross-linking group and is selected from a group consisting of: -SI(NR˝₂)₃, and -SI( R˝)₃, wherein R˝ is selected from a group consisting of alkyl, cycloalkyl or halogenated derivatives thereof, with the proviso that the halogen is not bonded to a carbon atom alpha in a carbonyl group.
Claim 19
Dependent Claim
13 words
A sensor as recited in claim 16 wherein R˝ is methyl or ethyl.
Claim 20
Dependent Claim
14 words
A sensor as recited in claim 17 wherein said fluorophore compound has the structure:
Claim 21
Dependent Claim
50 words
A compound for use in in vivo and in vitro monitoring of blood oxygen levels comprising silicone rubber and an oxygen-sensing fluorophore compound which is covalently bonded in said silicone rubber during curing thereof by employing said oxygen-sensing fluorophore compound as a cross-linking and curing agent for said silicone rubber.
Claim 22
Dependent Claim
50 words
A compound for use in in vivo and in vitro monitoring of blood oxygen levels comprising silicone rubber and an oxygen-sensing fluorophore compound which is covalently bonded in said silicone rubber during curing thereof by employing said oxygen-sensing fluorophore compound as a cross-linking and curing agent for said silicone rubber.
Claim 23
Dependent Claim
14 words
The compound as recited in claim 19 wherein said oxygen-sensing fluorophore has the structure:
References Cited (Backward Citations)
No citation records indexed.
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