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EP0420600A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Use of protease inhibitors as antiexudative, antiphlogistic and antimicrobial agents

Assignee: Czech Academy of Sciences
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Filing: 1990-09-26
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Granted: —
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Expires: 2010-09-26
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Abstract

Abstract A medcamentous form with antiexudation, antiphlogistic and antimicrobial effects in an aqueous or ointment base, suitable above all as an ophthalmologic, otolaryngologic, or dermatologic drug, which contains inhibitors or proteases, as are aprotinin, soyabean trypsine inhibitor, and elastatinal, either single or in a combination, in the amount of 0.1 mg to 20 mg per 1 ml of physiological saline or buffer solution, which is preferably ionically balanced and has pH 6.5 to 7.5, pr per 1 g of ointment base. The medicamentous form may further contain 0.05 to 1.5 wt.-% of steroidal antiphlogistics, for example, dexamethasone, and/or 0.05 to 5 wt.% of nonsteroidal antiphlogistics, for example, indomethacin, and/or 0.2 to 1 wt.-% of antibiotics suppressing the growth of microbes, as are, for example, neomycin, bacitracin, chloramphenicol, tetracycline.

Inventors

  • 👤 Jitka C/O Czechosl. Academy Of Sciences Cejkova
  • 👤 Jiri C/O Czechosl. Academy Of Sciences Vacik
  • 👤 Zdenek C/O Czechosl. Academy Of Sciences Lojda

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-30 22:53
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/55; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051

Claims Analysis

Total Claims: 15
Claim 1
Independent Claim 38 words
A pharmaceutically active composition having antiexudation, antiphlogistic and/or antimicrobial properties suitable for use as an ophthalmolgic, otolarynigologic or dermatologic medicament, having an aqueous or ointment base, characterised in that the composition comprises at least one inhibitor of proteases.
Claim 2
Dependent Claim 38 words
A pharmaceutically active composition having antiexudation, antiphlogistic and/or antimicrobial properties suitable for use as an ophthalmolgic, otolarynigologic or dermatologic medicament, having an aqueous or ointment base, characterised in that the composition comprises at least one inhibitor of proteases.
Claim 3
Dependent Claim 19 words
A composition as claimed in claim 1 wherein the inhibitor of proteases is aprotinin, soyabean trypsine inhibitor or elastatinal.
Claim 4
Dependent Claim 32 words
A composition as claimed in claim 1 or 2 wherein the composition comprises from 0.1 mg to 20 mg of inhibitor of proteases per 1 ml of physiological saline or buffer solution.
Claim 5
Dependent Claim 26 words
A composition as claimed in claim 3 wherein the buffer solution is ionically balanced and has a pH in the range of from 6.5 to 7.5.
Claim 6
Dependent Claim 28 words
A composition as claimed in claim 1 or 2 which composition comprises from 0.1 mg to 20 mg of inhibitor of proteases per 1 g of ointment base.
Claim 7
Dependent Claim 23 words
A composition as claimed in any preceding claim werein the composition further comprises from 0.05 to 1.5 wt% of a steroidal antiphlogistic agent.
Claim 8
Dependent Claim 14 words
A composition as claimed in claim 6 wherein the steroidal antiphlogistic agent is dexamethasone.
Claim 9
Dependent Claim 23 words
A composition as claimed in any preceding claim wherein the composition further comprises from 0.05 to 5 wt% of a non-steroidal antiphlogistic agent.
Claim 10
Dependent Claim 14 words
A composition as claimed in claim 8 wherein the non-steroidal antiphlogistic agent is indomethamin.
Claim 11
Dependent Claim 22 words
A composition as claimed in any preceding claim wherein the composition further comprises from 0.2 to 1 wt% of an antibiotic agent.
Claim 12
Dependent Claim 17 words
A composition as claimed in claim 10 wherein the antibiotic agent is neomycin, bacitracin, chloramphenicol or tetracycline.
Claim 13
Dependent Claim 43 words
A composition as claimed in any of claims 1 to 4 and 6 to 11, wherein the composition further comprises from 0.05 to 15 wt% of thickeners selected from hydroxypropyl methyl cellulose, methyl cellulose, polyvinylpyrrolidone, polyvinylalcohol, poly(alkylene glycols), poly[alkylene glycol (meth)acrylates] and poly(meth)acrylamides.
Claim 14
Dependent Claim 34 words
A composition as claimed in any of claims 1 to 4 and 6 to 12 when present in a hydrophilic matrix, which matrix is advantageously in the form of a strip or contact lens.
Claim 15
Dependent Claim 23 words
The use of the composition of any of claims 1 to 12 as an antiexudation, antiphlogistic and/or antimicrobial ophthalmologic, otolaryngologic or dermatologic treatment.

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