Patent EP0456467A2 successfully refreshed from Google Patents.
EP0456467A2
Expired / Lapsed
EP
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Contact lens cleaning and disinfecting with combinations of polymeric quaternary ammonium compounds and enzymes
Assignee: Alcon Vision LLC
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Filing: 1991-05-08
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Granted: —
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Expires: 2011-05-08
Abstract
Abstract Compositions containing an ophthalmically acceptable enzyme, a nitrogen-containing polymeric antimicrobial agent, and complexing agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. The complexing agent is citric acid, ethylenediaminetetraacetic acid, acetic acid or a pharmaceutically acceptable salt of these acids. The composition is provided in two-part form wherein a first component comprises the polymeric antimicrobial agent and the complexing agent and the second component comprises the enzyme. The two components are kept separate from each other prior to use. Methods for use of these compositions are also disclosed.
Inventors
- 👤 Ruth Ann Rosenthal
- 👤 Barry F. Van Duzee
- 👤 Rajkumar Bhatia
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 05:41
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/48; A; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/141; A61L12/142; A61L12/143; A61L12/145; C11D3/0005; C11D3/0078; C11D3/16; C11D3/20; C11D3/2075; C11D3/2086; C11D3/37; C11D3/3703; C11D3/3723; C11D3/38; C11D3/386; C11D3/38618
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
143 words
A two-part composition for cleaning and disinfecting a contact lens, comprising: a first component, comprising: an amount of a polymeric antimicrobial agent effective to disinfect the lens, said polymeric antimicrobial agent comprising a nitrogen-containing polymer or copolymer; and an amount of a complexing agent sufficient to provide a concentration of about 0.03 to about 0.7 percent by weight/volume when said composition is dissolved in a solution, said complexing agent selected from the group consisting of citric acid, ethylenediaminetetraacetic acid, acetic acid and pharmaceutically acceptable salts thereof; and a second component, comprising an amount of an ophthalmically acceptable enzyme sufficient to provide a concentration of less than or equal to about 50 proteolytic activity units per ml of solution when said composition is dissolved in a solution; wherein said first component and said second component are kept separate from each other prior to use.
Claim 2
Dependent Claim
28 words
The composition of claim 1 wherein said polymeric antimicrobial agent is selected from the group consisting of: polymeric quaternary ammonium compounds, polymeric biguanides, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
92 words
The composition of claim 2, wherein said polymeric antimicrobial agent is selected from the group consisting of: a) polymeric quaternary ammonium compounds having a number average molecular weight in the range of about 2,000 to about 30,000, said polymeric quaternary ammonium compounds having the formula: wherein: R₁, R₂ = OH, N(CH₃)₂, or N⁺(CH₂CH₂OH)₃; X is a pharmaceutically acceptable anion; and m = 0, 1 or 2; and b) polymeric biguanides of formula: or pharmaceutically acceptable salts thereof, having a number average molecular weight in the range of about 500 to about 120,000.
Claim 4
Dependent Claim
33 words
The composition of claim 3, wherein the concentration of said polymeric antimicrobial agent when the composition is in solution form is in the range of about 0.000001 to about 0.01 percent by weight/volume.
Claim 5
Dependent Claim
19 words
The composition of claim 4, wherein said polymeric antimicrobial agent comprises a polymeric quaternary ammonium compound of Formula (I).
Claim 6
Dependent Claim
9 words
The composition of claim 5, wherein X = chloride.
Claim 7
Dependent Claim
32 words
The composition of claim 5, wherein the concentration of said polymeric quaternary ammonium compound is sufficient to provide a concentration of about 0.001% by weight/volume when the composition is in solution form.
Claim 8
Dependent Claim
22 words
The composition of claim 5, wherein said polymeric antimicrobial agent comprises a mixture of the polymeric quaternary ammonium compounds of Formula (I).
Claim 9
Dependent Claim
26 words
The composition of claim 1, wherein the tonicity of the composition when in solution form is in the range of about 150 to about 300 mOsm/kg.
Claim 10
Dependent Claim
19 words
The composition of claim 1, wherein said enzyme is selected from the group consisting of pancreatin, papain, and subtilisin.
Claim 11
Dependent Claim
33 words
The composition of claim 1, wherein the concentration of said enzyme when the composition is in solution form is less than or equal to about 26 proteolytic activity units per ml of solution.
Claim 12
Dependent Claim
33 words
The composition of claim 11, wherein the concentration of said enzyme when the composition is in solution form is less than or equal to about 13 proteolytic activity units per ml of solution.
Claim 13
Dependent Claim
21 words
The composition of claim 1, wherein said second component further comprises an ophthalmically acceptable enzyme having lipolytic, mucolytic or amylolytic activity.
Claim 14
Dependent Claim
14 words
The composition of claim 1, wherein said second component is formulated as a tablet.
Claim 15
Dependent Claim
32 words
The composition of claim 14, wherein said tablet comprises an enzyme core and an outer coating to delay release of said enzyme core when said tablet is added to said first component.
Claim 16
Independent Claim
128 words
A method of cleaning and disinfecting a contact lens, comprising the steps of: immersing the contact lens in an aqueous solution comprising: an amount of a polymeric antimicrobial agent effective to disinfect the contact lens, said polymeric antimicrobial agent comprising a nitrogen-containing polymer or co-polymer; and about 0.03 to about 0.7 percent by weight/volume of a complexing agent, said complexing agent selected from the group consisting of citric acid, ethylenediaminetetraacetic acid, acetic acid and pharmaceutically acceptable salts thereof; releasing into said aqueous solution an amount of an ophthalmically acceptable enzyme sufficient to provide a concentration of less than or equal to about 50 proteolytic units of activity; and maintaining immersion of the contact lens in said aqueous solution for a period sufficient to clean and disinfect the lens.
Claim 17
Dependent Claim
28 words
The method of claim 16, wherein the polymeric antimicrobial agent is selected from the group consisting of: polymeric quaternary ammonium compounds, polymeric biguanides, and pharmaceutically acceptable salts thereof.
Claim 18
Dependent Claim
92 words
The method of claim 17, wherein the polymeric antimicrobial agent is selected from the group consisting of: a) polymeric quaternary ammonium compounds having a number average molecular weight in the range of about 2,000 to about 30,000, said polymeric quaternary ammonium compounds having the formula: wherein: R₁, R₂ = OH, N(CH₃)₂, or N⁺(CH₂CH₂OH)₃; X is a pharmaceutically acceptable anion; and m = 0, 1 or 2; and b) polymeric biguanides of formula: or pharmaceutically acceptable salts thereof, having a number average molecular weight in the range of about 500 to about 120,000.
Claim 19
Dependent Claim
25 words
The method of claim 18, wherein the concentration of said polymeric antimicrobial agent is in the range of about 0.000001% to about 0.01% by weight/volume.
Claim 20
Dependent Claim
19 words
The method of claim 19, wherein the polymeric antimicrobial agent comprises a polymeric quaternary ammonium compound of Formula (I).
Claim 21
Dependent Claim
9 words
The method of claim 20, wherein X = chloride.
Claim 22
Dependent Claim
22 words
The method of claim 20, wherein said polymeric antimicrobial agent comprises a mixture of the polymeric quaternary ammonium compounds of Formula (I).
Claim 23
Dependent Claim
22 words
The method of claim 16, wherein said second component further comprises an ophthalmically acceptable enzyme having a lipolytic, mucolytic, or amylolytic activity.
Claim 24
Dependent Claim
19 words
The method of claim 16, wherein said enzyme is selected from the group consisting of pancreatin, papain, and subtilisin.
Claim 25
Dependent Claim
26 words
The method of claim 16, wherein the concentration of said enzyme is less than or equal to about 26 proteolytic activity units per ml of solution.
Claim 26
Dependent Claim
26 words
The method of claim 24, wherein the concentration of said enzyme is less than or equal to about 13 proteolytic activity units per ml of solution.
References Cited (Backward Citations)
No citation records indexed.
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