EP0457570A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Nucleoside-phospholipid conjugate
Assignee: Asahi Kasei Corp
•
Filing: 1991-05-15
•
Granted: —
•
Expires: 2011-05-15
Abstract
Abstract A compound which is a nucleoside-phospholipid conjugate of formula: wherein R₁ and R₂, which are the same or different, are C₁₄₋₂₀ aliphatic acyl groups or a pharmacologically acceptable salt thereof.
Inventors
- 👤 Satoshi Shuto
- 👤 Hiromichi Itoh
- 👤 Takumi Obara
- 👤 Tatsuro Fujiwara
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 18:01
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/543; A61K47/544; A61P; A61P35/00; C12; C12P; C12P19/00; C12P19/26; C12P19/28; C12P19/30; C12P19/305
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
30 words
A compound which is a nucleoside-phospholipid conjugate of formula: wherein R₁ and R₂, which are the same or different, are C₁₄₋₂₀ aliphatic acyl groups or a pharmacologically acceptable salt thereof.
Claim 2
Dependent Claim
20 words
A compound according to claim 1 wherein at least one of R₁ and R₂ is a C₁₆₋₁₈ aliphatic acyl group.
Claim 3
Dependent Claim
25 words
A compound according to claim 2 wherein R₁ is a palmitoyl, stearoyl or oleoyl group and R₂ is a palmitoyl, stearoyl, oleoyl or linoleoyl group.
Claim 4
Dependent Claim
67 words
A process for the preparation of a compound as defined in any one of claims 1 to 3, which comprises reacting a glycerophospholipid of formula (II): wherein R₁ and R₂ are as defined in claim 1 and R₃ is a choline residue, with a nucleoside in the presence of a phospholipase D and, if desired, converting the nucleoside-phospholipid conjugate thus obtained into a pharmacologically acceptable salt thereof.
Claim 5
Dependent Claim
22 words
A pharmaceutical composition which comprises a compound as defined in any one of claims 1 to 3 and a pharmaceutically acceptable diluent.
Claim 6
Dependent Claim
27 words
A compound as defined in any one of claims 1 to 3 for use in a method of treatment of the human or animal body by therapy.
Claim 7
Dependent Claim
24 words
A compound as defined in any one of claims 1 to 3 for use in a method of treatment of a tumor or leukemia.
Claim 8
Dependent Claim
28 words
Use of a compound as defined in any one of claims 1 to 3 in the manufacture of a medicament for the treatment of a tumor or leukemia.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.