Patent EP0519087A1 successfully refreshed from Google Patents.
EP0519087A1
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EP
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Method for pretreating the surface of a medical device
Assignee: Hewlett Packard GmbH Germany
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Filing: 1991-05-21
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Granted: —
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Expires: 2011-05-21
Abstract
Abstract A method for pretreating the surface of a medical device, and of applying a polymer coating, in order to apply a biological coating in a further step, uses the plasma polymerization technique or the plasma grafting technique. A functional monomer, i.e. a monomer with a functional group, or a mixture of a pure monomer and a substance able to provide the required functional groups under spark discharge or under the influence of charge carriers, results in a polymer coating with free functional groups, which may react with the biological coating, thus providing optimum adhesion of the biological coating. The process is carried out in a pressure-tight chamber (39) with an inlet (48) for the functional monomer under low pressure and electromagnetic radiation provided by a radiation source (45).
Inventors
- 👤 Lothar Rupp
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 14:15
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0076; A61L33/0088; A61L33/0005; A61L33/0011; A61L33/0029
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
115 words
Method of pretreating the surface of a medical device for appliance of a biological coating, characterized by the steps of: (1.1) exposing said medical device to a chemical agent consisting of monomer molecules chemically combined with functional groups, or of a monomer mixed with a substance which, under the influence of electromagnetic radiation, forms a functional group which binds chemically to said monomer, said chemical agent being present at least in its gaseous state, (1.2) irradiating electromagnetic waves, in particular of the radio frequency range, into said chemical agent and/or onto the surface of said medical device until the molecules of said chemical agent constitute a functional polymer on the surface of said medical device.
Claim 2
Dependent Claim
129 words
Method for applying a biological coating to the surface of a medical device intended for blood contact, characterized by the steps of: (2.1) exposing said medical device to a chemical agent consisting of monomer molecules chemically combined with functional groups, or of a monomer mixed with a substance which, under the influence of electromagnetic radiation, forms a functional group which binds chemically to said monomer, said chemical agent being present at least in its gaseous state, (2.2) irradiating electromagnetic waves, in particular in the radio frequency range, into said chemical agent and/or onto the surface of said medical device until the molecules of said chemical agent constitute a functional polymer on the surface of said medical device, (2.3) applying said biological coating to the surface of said medical device.
Claim 3
Dependent Claim
128 words
Method of pretreating the surface of a medical device for appliance of a biological coating, characterized by the steps of: (3.1) exposing said medical device to an inert gas, (3.2) irradiating electromagnetic waves, in particular of the radio frequency range, into said inert gas and/or onto the surface of said medical device, (3.3) exposing said medical device to a chemical agent consisting of monomer molecules chemically combined with functional groups, or of a monomer mixed with a substance which, under the influence of charge carriers created during step (3.2), forms a functional group which binds chemically to said monomer, said chemical agent being present at least in its gaseous state, until the molecules of said chemical agent constitute a functional polymer on the surface of said medical device.
Claim 4
Dependent Claim
142 words
Method for applying a biological coating to the surface of a medical device intended for blood contact, characterized by the steps of: (4.1) exposing said medical device to an inert gas, (4.2) irradiating electromagnetic waves, in particular of the radio frequency range, into said inert gas and/or onto the surface of said medical device, (4.3) exposing said medical device to a chemical agent consisting of monomer molecules chemically combined with functional groups, or of a monomer mixed with a substance which, under the influence of charge carriers created during step (4.2), forms a functional group which binds chemically to said monomer, said chemical agent being present at least in its gaseous state, until the molecules of said chemical agent constitute a functional polymer on the surface of said medical device, (4.4) applying said biological coating to the surface of said medical device.
Claim 5
Dependent Claim
27 words
Method according to any of the preceding claims, characterized in that said chemical agent is contained in a closed chamber (39) which also contains said medical device.
Claim 6
Dependent Claim
25 words
Method according to claim 5, characterized in that said chamber (39) is pressure-tight and that a pressure below atmospheric pressure is applied to said chamber.
Claim 7
Dependent Claim
41 words
Method according to claim 6, characterized in that the pressure in said chamber (39) is approximately a vacuum, in particular in the range of 10⁻⁵ bar to 10⁻² bar and more specifically in the range of 10⁻⁴ bar to 10⁻³ bar.
Claim 8
Dependent Claim
26 words
Method according to any of the preceding claims, characterized in that said monomer comprises molecules consisting of at least two carbon atoms combined by double bond.
Claim 9
Dependent Claim
25 words
Method according to any of the preceding claims, characterized in that said functional group in said molecules of said chemical agent is an amino group.
Claim 10
Dependent Claim
30 words
Method according to claim 9, characterized in that said chemical agent is allylamine, 4-amino-1-butene or any other olefin with additional amino group, or a combination of olefin and ammonium hydroxyde.
Claim 11
Dependent Claim
26 words
Method according to any of claims 1 to 8, characterized in that said functional group in said molecules of said chemical agent is a carboxyl group.
Claim 12
Dependent Claim
29 words
Method according to claim 11, characterized in that said chemical agent is one selected of the group of carboxylic acids, in particular acrylic acid, butenoic acid, or pentenoic acid.
Claim 13
Dependent Claim
26 words
Method according to any of claims 1 to 8, characterized in that said functional group in said molecules of said chemical agent is an OH group.
Claim 14
Dependent Claim
14 words
Method according to claim 13, characterized in that said chemical agent is ally alcohol.
Claim 15
Dependent Claim
71 words
Method according to any of the preceding claims, characterized by the additional steps of (15.1) exposing said medical device to a chemically active gas, in particular oxygen, (15.2) irradiating electromagnetic waves into said chemically active gas and/or onto the surface of said medical device until the surface of said medical device is substantially clean of impurities, wherein said steps are performed prior to exposing said medical device to said chemical agent.
Claim 16
Dependent Claim
37 words
Method according to any of the preceding claims, characterized by the step of applying said biological coating to the polymerized surface of said medical device by means of esterification, acid amide formation, acid amine formation, or etherification.
Claim 17
Dependent Claim
20 words
Method according to any of the preceding claims, characterized in that said medical device is an intravascular blood gas sensor.
Claim 18
Dependent Claim
121 words
Apparatus for pretreatment of the surface of a medical device for appliance of a biological coating, said apparatus comprising a pressure-tight chamber (39) with a releasable lock for insertion of said medical device and with a source (45) of electromagnetic radiation, preferably in the radio frequency range, for performing plasma polymerization, characterized by a container (54) filled with a chemical agent consisting of monomer molecules chemically combined with functional groups, or consisting of a monomer mixed with a substance which, under the influence of electromagnetic radiation or of charge carriers, forms a functional group which binds chemically to said monomer, said chemical agent being present at least in its gaseous state, said container (54) being lockably connected with said chamber (39).
Claim 19
Dependent Claim
28 words
Apparatus according to claim 18, characterized by a second container (52;53) filled with a chemically active gas or an inert gas and being lockably connected with said chamber.
Claim 20
Dependent Claim
33 words
Apparatus according to claim 18 or 19, characterized by a shelf or rack (40) in said chamber (39) suited for suspending or hanging of said medical devices, in particular intravascular blood gas sensors.
Claim 21
Dependent Claim
56 words
Use of a chemical agent consisting of monomer molecules chemically combined with functional groups, or of a monomer mixed with a substance which, under the influence of electromagnetic radiation or of charge carriers, forms a functional group which binds chemically to said monomer, for pretreatment of a medical device prior to appliance of a biological coating.
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