EP0590786A1
Expired / Lapsed
EP
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Use of certain anionic surfactants to enhance antimicrobial effectiveness of opthalmic compositions
Assignee: Alcon Vision LLC
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Filing: 1993-08-23
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Granted: —
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Expires: 2013-08-23
Abstract
Abstract Certain anionic surfactants are used to enhance antimicrobial effectiveness in comfortable, sustained release ophthalmic compositions containing polyelectrolytes, such as carboxyvinyl polymers, polystyrene sulfonic acid polymers and cationic exchange resins, as well as at least one active ingredient.
Inventors
- 👤 Ernest J. Castillo
- 👤 Yusuf Ali
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 15:33
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K47/16; A61K47/18; A61K47/183; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
100 words
A method of improving or enhancing the antimicrobial efficacy of an ophthalmic composition comprising a cationic antimicrobial, a polyelectrolyte and an active ingredient, said method comprising adding to said composition an antimicrobial-enhancing amount of an anionic surfactant selected from the group consisting of: a) a compound of formula: wherein: R¹ = C₄-C₂₇ saturated or unsaturated hydrocarbon; M = H or a pharmaceutically acceptable salt; and n = 1, 2 or 3; and b) a compound of formula: wherein: R² = C₄-C₂₇ saturated or unsaturated hydrocarbon; M = H or a pharmaceutically acceptable salt; and n = 1, 2 or 3.
Claim 2
Dependent Claim
21 words
The method of claim 1, wherein the final composition concentration of said surfactant is between about 0.005 and about 5.0 wt%.
Claim 3
Dependent Claim
15 words
The method of claim 2, wherein the surfactant comprises a compound of formula I .
Claim 4
Dependent Claim
21 words
The method of claim 3, wherein the final composition concentration of said surfactant is between about 0.005 and about 0.5 wt%.
Claim 5
Dependent Claim
21 words
The method of claim 4, wherein the final composition concentration of said surfactant is between about 0.01 and about 0.2 wt%.
Claim 6
Dependent Claim
21 words
The method of claim 5, wherein the final composition concentration of said surfactant is between about 0.03 and about 0.12 wt%.
Claim 7
Dependent Claim
15 words
The method of claim 2, wherein the surfactant comprises a compound of formula II .
Claim 8
Dependent Claim
21 words
The method of claim 7, wherein the final composition concentration of said surfactant is between about 0.1 and about 5.0 wt%.
Claim 9
Dependent Claim
21 words
The method of claim 8, wherein the final composition concentration of said surfactant is between about 0.1 and about 2.0 wt%.
Claim 10
Dependent Claim
17 words
The method of claim 9, wherein the final composition concentration of said surfactant is about 0.5 wt%.
Claim 11
Dependent Claim
31 words
The method of claim 1, wherein said surfactant is selected from the group consisting of lauroyl sarcosine, oleoyl sarcosine, myrstoyl sarcosine, cocoyl sarcosine, stearoyl sarcosine, pelargodoyl sarcosine and sodium capryl lactylate.
Claim 12
Dependent Claim
12 words
The method of claim 1, wherein said cationic antimicrobial comprises benzalkonium chloride.
Claim 13
Dependent Claim
27 words
The method of claim 1, wherein said polyelectrolyte is selected from the group consisting of: carboxyvinyl polymers, polystyrene sulfonic acid polymers and finely divided cationic exchange resins.
Claim 14
Dependent Claim
12 words
The method of claim 13, wherein said polyelectrolyte comprises a carboxyvinyl polymer.
Claim 15
Dependent Claim
46 words
The method of claim 13, wherein said polyelectrolyte comprises a polystyrene sulfonic acid polymer of formula: wherein: R = H or CH₃; and X = an integer such that the molecular weight of the polystyrene sulfonic acid polymer may vary from about 10,000 to 1.6 million.
Claim 16
Dependent Claim
15 words
The method of claim 13, wherein said polyelectrolyte comprises a finely divided cationic exchange resin.
Claim 17
Dependent Claim
92 words
An ophthalmic composition having enhanced or improved antimicrobial efficacy, said composition comprising a cationic antimicrobial, a polyelectrolyte, an active ingredient, and an anionic surfactant, wherein said anionic surfactant is selected from the group consisting of: a) a compound of formula: wherein: R¹ = C₄-C₂₇ saturated or unsaturated hydrocarbon; M = H or a pharmaceutically acceptable salt; and n = 1, 2 or 3; and b) a compound of formula: wherein: R² = C₄-C₂₇ saturated or unsaturated hydrocarbon; M = H or a pharmaceutically acceptable salt; and n = 1, 2 or 3.
Claim 18
Dependent Claim
21 words
The composition of claim 17, wherein the final composition concentration of said surfactant is between about 0.005 and about 5.0 wt%.
Claim 19
Dependent Claim
15 words
The composition of claim 17, wherein said surfactant comprises a compound of formula I .
Claim 20
Dependent Claim
20 words
The composition of claim 19, wherein the final composition concentration of said surfactant is between about 0.01 and 0.5 wt%.
Claim 21
Dependent Claim
15 words
The composition of claim 17, wherein said surfactant comprises a compound of formula II .
Claim 22
Dependent Claim
20 words
The composition of claim 21, wherein the final composition concentration of said surfactant is between about 0.1 and 5.0 wt%.
Claim 23
Dependent Claim
31 words
The composition of claim 17, wherein said surfactant is selected from the group consisting of lauroyl sarcosine, oleoyl sarcosine, myrstoyl sarcosine, cocoyl sarcosine, stearoyl sarcosine, pelargodoyl sarcosine and sodium capryl lactylate.
Claim 24
Dependent Claim
12 words
The composition of claim 17, wherein the active ingredient comprises a beta-blocker.
Claim 25
Dependent Claim
18 words
The composition of claim 24, wherein the beta-blocker is selected from the group consisting of betaxolol and timolol.
Claim 26
Dependent Claim
27 words
The composition of claim 17, wherein said polyelectrolyte is selected from the group consisting of: carboxyvinyl polymers, polystyrene sulfonic acid polymers and finely divided cationic exchange resins.
References Cited (Backward Citations)
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