EP0771849A2
Expired / Lapsed
EP
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Polymer blends containing polyoxaesters
Assignee: Ethicon Inc
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Filing: 1996-11-05
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Granted: —
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Expires: 2016-11-05
Abstract
Abstract The present invention describes a new aliphatic polyoxaesters and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I: [O-C(O)-C(R 1 )(R 2 )-O-(R 3 )-O-C(R 1 )(R 2 )-C(O)-] I and a second repeating unit selected from the group of formulas consisting of: [-O-R 4 -] A , II [-O-R 5 -C(O)-] B , III and ([-O-R 5 -C(O)] P -O-) L G XI and combinations thereof. These aliphatic polyoxaesters may be blended with other polymers which are preferably biocompatable.
Inventors
- 👤 Rao S. Bezwada
- 👤 Dennis D. Jamiolkowski
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 18:55
CPC Classifications
C; C08; C08L; C08L67/00; C08L67/02; C08L67/025; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/26; A61L15/42; A61L15/60; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/52; A61L27/58; A61L29/00; A61L29/04; A61L29/049; A61L29/06; A61L29/14; A61L29/145; A61L31/00; A61L31/04; A61L31/041; A61L31/06; C08G; C08G63/00; C08G63/66; C08G63/664; C08G63/668; C08G63/672; C08G69/00; C08G69/40; C08G69/44; C09; C09D; C09D167/00; C08L101/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
444 words
A polymer blend comprising an aliphatic polyoxaesters having a first divalent repeating unit of formula I: [O-C(O)-C(R 1 )(R 2 )-O-(R 3 )-O-C(R 1 )(R 2 )-C(O)-] I and a second repeating unit selected from the group of formulas consisting of: [-O-R 4 -] A , II [-O-R 5 -C(O)-] B , and III ([-O-R 5 -C(O)] P -O-) L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: -[(CH 2 ) C -O-] D -(CH 2 ) E - IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms ; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of -C(R 6 ) (R 7 )-, -(CH 2 ) 3 -0-, -CH 2 -CH 2 -O-CH 2 -, -CR 8 H-CH 2 -, - (CH 2 ) 4 -, -(CH 2 ) F -0-C(O) - and -(CH 2 ) F -C(O) -CH 2 -; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; and a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate) and combinations thereof.
Claim 2
Dependent Claim
43 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [-O-C(O)-C(R 1 )(R 2 )-O-(R 3 )-O-C(R 1 )(R 2 )C(O)-(O-R 4 ) A -] N wherein N is an integer in the range of from about 1 to about 10,000
Claim 3
Dependent Claim
64 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [(-C(O)-C(R 1 )(R 2 )-O-R 3 -O-C(R 1 )(R 2 )-C(O)-(OR 4 ) A -O) S (C(O)-R 5 -O) B ] W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 4
Dependent Claim
66 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [(-C(O)-C(R 1 )(R 2 )-O-R 3 -O-C(R 1 )(R 2 )-C(O)-(O-R 4 ) A -O) S ([-O-R 5 -C(O)] P -O-) L G] W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 5
Independent Claim
15 words
A device made from a polymer blend of any one of claims 1 to 4.
Claim 6
Dependent Claim
74 words
The device of claim 5 which is an absorbable surgical device, such as burn dressing, hernia patch, medicated dressing, fascial substitute, gauze, fabric , sheet, felt, sponge, gauze bandage, arterial graft bandage for skin surfaces, suture knot clip, pin, clamp, screw, plate, clip, staple, hook, button, snap, bone substitute , intrauterine device, tube, surgical instrument, vascular implant, vascular support, vertebral disc, artificial skin, or a filament which filament is optionally attached to a needle.
Claim 7
Independent Claim
15 words
A device coated with a polymer blend of any one of claims 1 to 4.
Claim 8
Dependent Claim
19 words
A drug delivery matrix comprising a drug and a polymer blend of any one of claims 1 to 4.
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