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EP0794208A2
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Absorbable polyoxaesters
Assignee: Ethicon Inc
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Filing: 1997-03-04
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Granted: —
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Expires: 2017-03-04
Abstract
Abstract The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I: [O-C(O)-C(R 1 )(R 2 )-O-(R 3 )-O-C(R 1 )(R 2 )-C(O)-] I and a second repeating unit selected from the group of formulas consisting of: [-O-R 4 -] A , II [-O-R 5 -C(O)-] B , and III ([-O-R 5 -C(O)] P -O-) L G XI and combinations thereof.
Inventors
- 👤 Rao S. Bezwada
- 👤 Dennis D. Jamiolkowski
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-02 22:58
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/668; C08G63/672; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/26; A61L15/42; A61L15/60; A61L15/64; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/52; A61L27/58; A61L29/00; A61L29/04; A61L29/049; A61L29/06; A61L29/14; A61L29/145; A61L31/00; A61L31/04; A61L31/041; A61L31/06; A61L31/14; A61L31/148; C08G63/664; C08G69/00; C08G69/40; C08G69/44; C08L; C08L67/00; C08L67/02; C08L67/025; C09; C09D; C09D167/00; C08L101/00; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/1355; Y10T428/1362; Y10T428/24; Y10T428/249921; Y10T428/249953; Y10T428/29; Y10T428/2904; Y10T428/2913; Y10T428/2933; Y10T428/294; Y10T428/2942; Y10T428/2947; Y10T428/31504; Y10T428/31551
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
379 words
An aliphatic polyoxaesters comprising a first divalent repeating unit of formula I: [O-C(O)-C(R 1 ) (R 2 )-O-(R 3 )-O-C(R 1 ) (R 2 )-C(O)-] I and a second repeating unit selected from the group of formulas consisting of: [-O-R 4 -] A , II [-O-R 5 -C(O)-] B , III and ([-O-R 5 -C(O)] P -O-) L G XI and combinations thereof, wherein R 1 and R 2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: -[(CH 2 ) C -O-] D -(CH 2 ) E - IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer from 2 to 12; R 4 is an alkylene unit containing from 2 to 8 carbon atoms ; A is an integer in the range of from 1 to 2,000; R 5 is selected from the group consisting of -C(R 6 ) (R 7 )-, -(CH 2 ) 3 -0-, -CH 2 -CH 2 -O-CH 2 -, -CR 8 H-CH 2 -, -(CH 2 ) 4 -, -(CH 2 ) F -0-C(O)- and -(CH 2 ) F -C(O)-CH 2 -; R 6 and R 7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R 8 is hydrogen or methyl; F is an integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 2
Dependent Claim
45 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [-O-C(O)-C(R 1 ) (R 2 )-O-(R 3 )-O-C(R 1 ) (R 2 )C(O)-(O-R 4 ) A -] N wherein N is an integer in the range of from about 1 to about 10,000
Claim 3
Dependent Claim
64 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [(-C(O)-C(R 1 ) (R 2 )-O-R 3 -O-C(R 1 ) (R 2 )-C(O)-(O-R 4 ) A -O) S (C(O)-R 5 -O) B ] W wherein S is integers in the range of from about 1 to about 10,000 and W is integers in the range of from about 1 to about 1,000.
Claim 4
Dependent Claim
68 words
The aliphatic polyoxaesters of claim 1 wherein the polymer has the formula: [(-C(O)-C(R 1 ) (R 2 )-O-R 3 -O-C(R 1 ) (R 2 )-C(O)-(O-R 4 ) A -O) S ([-O-R 5 -C(O)] P -O-) L G] W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 5
Independent Claim
17 words
A device made from an aliphatic polyoxaester as defined in any one of claims 1 to 4.
Claim 6
Dependent Claim
84 words
The device of claim 5 wherein the device is: either an absorbable surgical device, such as a surgical device selected from the group consisting of burn dressings, hernia patches, medicated dressings, fascial substitutes, gauze, fabrics, sheets, felts, sponges, gauze bandages, arterial grafts, bandages for skin surfaces, suture knot clips, pins, clamps, screws, plates, clips, staples, hooks, buttons, snaps, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin; or a filament, which is optionally attached to a needle.
Claim 7
Independent Claim
55 words
A device coated with an absorbable coating comprising an aliphatic polyoxaester as defined in any one of claims 1 to 4 wherein the inherent viscosity of the polyoxaester is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25°C.
Claim 8
Dependent Claim
18 words
The device of claim 7 wherein the device is a suture, which is optionally attached to a needle.
Claim 9
Dependent Claim
21 words
A drug delivery matrix comprising a drug and an aliphatic polyoxaester as defined in any one of claims 1 to 4.
References Cited (Backward Citations)
No citation records indexed.
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