Patent EP0806475A2 successfully refreshed from Google Patents.
EP0806475A2
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EP
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Filter apparatus and method of separating micro-tissues of an organism using said filter apparatus
Assignee: Terumo Corp
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Filing: 1997-03-28
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Granted: —
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Expires: 2017-03-28
Abstract
Abstract A filter apparatus (1B) is formed by a housing (2), a filter member (5) disposed in the housing (2), flow-passage maintaining members (6a and 6b) disposed on the two sides of the filter member (5), screw thread portions (32) and thread grooves (44) which are a porosity changing unit. The housing (2) is formed by a first housing member (3) having a first port (31) and a second housing member (4) having a second port (41). The filter member (5) is formed by stacking a plurality of porous polymer sheets (51). It is preferable that the porous polymer sheets (51) have gradient of physical or chemical characteristic in a direction of stacking. By operating the porosity changing means, the filter member (5) is set to a compressive state or a non-compressive state. In the compressive state, a first porosity capable of capturing the objective cells is set. In the non-compressive state, a second porosity which is higher than the first porosity is set.
Inventors
- 👤 Yoshitaka c/o Terumo Kabushiki Kaisha Ohmura
- 👤 Noboru c/o Terumo Kabushiki Kaisha Taguchi
- 👤 Tadashi c/o Terumo Kabushiki Kaisha Sameshima
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 07:29
CPC Classifications
B; B01; B01D; B01D69/00; B01D69/12; B01D69/1218; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; B01D61/00; B01D61/14; B01D61/18; B01D69/02; G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
53 words
A filter apparatus (1A to 1E) comprising: a housing (2) having first and second ports (31, 41); and a filter member (5) composed of a porous material, which is disposed in said housing, wherein a porosity of said filter member (5) can be set to be two or more different degrees of porosity.
Claim 2
Dependent Claim
113 words
A filter apparatus (1A to 1E) comprising: a housing (2) having first and second ports (31, 41); and a filter member (5) composed of a porous material, which is disposed in said housing (2) so that inner space of the housing (2) is partitioned into a first chamber communicated with said first port (31) and a second chamber communicated with said second port (41); and a means (7, 32, 44, 9, 8) for changing porosity of said filter member (5), which can set the porosity of the filter member to a first porosity capable of capturing at least objective micro-tissue to be separated and to a second porosity larger than the first porosity.
Claim 3
Dependent Claim
31 words
A filter apparatus (1A to 1E) according to claim 2, characterized in that the ratio of the second porosity with respect to the first porosity is 1.05 times to 3.0 times.
Claim 4
Dependent Claim
38 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 3, characterized in that the filter member (5) has a gradient of physical or a chemical characteristic in a direction along which fluid flows.
Claim 5
Dependent Claim
48 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 4, characterized in that the filter member (5) comprises a plurality of porous materials (51), and all or a part of the plural porous materials (51) has a gradient of physical or chemical characteristic.
Claim 6
Dependent Claim
32 words
A filter apparatus (1A to 1E) according to claim 4 or 5, characterized in that the gradient of physical or chemical characteristic comprises change of pore size of the porous material (51).
Claim 7
Dependent Claim
32 words
A filter apparatus (1A to 1E) according to claim 4 or 5, characterized in that the gradient of physical or chemical characteristic comprises change of the porosity of the porous material (51).
Claim 8
Dependent Claim
30 words
A filter apparatus (1A to 1E) according to claim 4 or 5, characterized in that the gradient of physical or chemical characteristic comprises the hydrophilicity of the porous material (51).
Claim 9
Dependent Claim
33 words
A filter apparatus (1A to 1E) according to claim 4 or 5, characterized in that the gradient of physical or chemical characteristic comprises change of the zeta potential of the porous material (51).
Claim 10
Dependent Claim
52 words
filter apparatus (1A to 1E) according to any one of claims 1 to 9, characterized in that the filter member (5) is elastically deformable, and the porosity thereof is adjusted by compressing the filter member (5) to lower the porosity or by releasing or weakening the compressive force to raise the porosity.
Claim 11
Dependent Claim
53 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 9, characterized in that the filter member (5) is elastically deformable, and the porosity thereof is adjusted by stretching the filter member (5) to raise the porosity or by releasing or weakening the stretching force to lower the porosity.
Claim 12
Dependent Claim
43 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 11, characterized in that the filter member (5) has such a structure that rise and lowering of the porosity correspond to enlargement and reduction of the pore size, respectively.
Claim 13
Dependent Claim
39 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 12, characterized in that the change of the porosity of the filter member (5) is caused with accompanied by volumetric change of the housing (2).
Claim 14
Dependent Claim
83 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 13, characterized in that the housing (2) comprises a first housing member (3) and a second housing member (4) capable of moving in a liquid-tight fashion with respect to the first housing member (3), and relative movement of the second housing member (4) with respect to the first housing member (3) causes deformation of the filter member (5) so as to change the porosity of the filter member (5).
Claim 15
Dependent Claim
36 words
A filter apparatus (1A to 1E) according to claim 14, characterized by further comprising at least one seal member (43) for maintaining the liquid-tightness between the first housing member (3) and the second housing member (4).
Claim 16
Dependent Claim
49 words
A filter apparatus (1A to 1E) according to any one of claims 1 to 15, characterized by further comprising a fluid-passage maintaining member (6a, 6b) for maintaining a flowing passage of liquid which is introduced through the first port (31) and/or the second port (41) to the filter member.
Claim 17
Independent Claim
111 words
A method of separating objective micro-tissues of an organism by using a filter member (5) made of a porous material having a porosity which can be changed, the method comprising the steps of: filtering the objective micro-tissues by using the filter member (5) which is in such a state that the porosity of the filter member (5) has been set to a first porosity capable of capturing the objective micro-tissues; and recovering the objective micro-tissues captured by the filter member (5), the recovery being performed in such a state that the porosity of the filter member (5) has been set to a second porosity which is higher than the first porosity.
Claim 18
Independent Claim
158 words
A method of separating objective micro-tissues of an organism by using a filter apparatus (1A to 1E) which comprises a housing (2) having first and second ports (31, 41) and accommodates a filter member (5) made of porous material having a variable porosity, the method comprising the steps of: supplying liquid to be treated containing the objective micro-tissues through the first port (31) to the filter member (5) and separate the objective micro-tissues by passing the liquid through the filter member (5) in such a state that the porosity of the filter member (5) has been set to a first porosity capable of capturing the objective micro-tissues; and supplying recovering liquid through the second port (41) to the filter member (5) in such a state that the porosity of the filter member (5) has been set to a second porosity which is higher than the first porosity, thereby recovering the objective micro-tissues captured by the filter member (5).
Claim 19
Independent Claim
175 words
A method of separating objective micro-tissues of an organism by using a filter apparatus (1A to 1E) which comprises a housing (2) having first and second ports (31, 32) and accommodates a filter member (5) made of porous material having a variable porosity, the method comprising the steps of: supplying liquid to be treated containing the objective micro-tissues through the first port (31) to the filter member (5) and separate the objective micro-tissues by passing the liquid through the filter member (5) in such a state that the porosity of the filter member (5) has been set to a first porosity capable of capturing the objective micro-tissues; supplying washing liquid through the first port (31), thereby washing the filter member (5); and supplying recovering liquid through the second port (41) to the filter member (5) in such a state that the porosity of the filter member (5) has been set to a second porosity which is higher than the first porosity, thereby recovering the micro-tissues of a living body captured by the filter member (5).
Claim 20
Dependent Claim
55 words
A method of separating the objective micro-tissues according to claim 19, characterized in that said washing step of the filter member (5) is performed in such a state that the porosity of the filter member (5) has been set to a level which is higher than the first porosity and lower than the second porosity.
Claim 21
Dependent Claim
39 words
A method of separating the objective micro-tissues according to claim 19, characterized in that said washing step of the filter member (5) is performed in such a state that the first porosity of the filter member (5) is retained.
Claim 22
Independent Claim
37 words
A method of separating the objective micro-tissues according to any one of claims 17 to 21, characterized in that the ratio of the second porosity with respect to the first porosity is 1.05 times to 3.0 times.
Claim 23
Independent Claim
33 words
A method of separating the objective micro-tissues according to any one of claims 17 to 22, characterized in that the filter member (5) comprises a laminate of a plurality of porous material (51).
Claim 24
Independent Claim
40 words
A method of separating the objective micro-tissues according to any one of claims 17 to 23, characterized in that the filter member (5) has a gradient of physical or a chemical characteristic in a direction along which the liquid flows.
Claim 25
Dependent Claim
33 words
A method of separating the objective micro-tissues according to claim 24, characterized in that the gradient of physical or chemical characteristic comprises change of the diameter of pores of the porous material (51).
Claim 26
Dependent Claim
31 words
A method of separating the objective micro-tissues according to claim 24, characterized in that the gradient of physical or chemical characteristic comprises change of the porosity of the porous material (51).
Claim 27
Dependent Claim
31 words
A method of separating the objective micro-tissues according to claim 24, characterized in that the gradient of physical or chemical characteristic comprises change of the hydrophilicity of the porous member (5).
Claim 28
Dependent Claim
32 words
A method of separating the objective micro-tissues according to claim 24, characterized in that the gradient of physical or chemical characteristic comprises change of the zeta potential of the porous material (51).
Claim 29
Independent Claim
46 words
A method of separating the objective micro-tissues according to any one of claims 17 to 28, characterized in that the filter member (5) has such a structure that rise and lowering of the porosity correspond to enlargement and reduction of the diameter of the pores, respectively.
Claim 30
Independent Claim
51 words
A method of separating the objective micro-tissues according to any one of claims 18 to 21, characterized by further comprising a fluid-passage maintaining member (6a, 6b) for maintaining a flowing passage of liquid which is introduced through the first port (31) and/or the second port (41) to the filter member (5).
References Cited (Backward Citations)
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