EP0809997A2
Expired / Lapsed
EP
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Medical device with biomolecule-coated surface graft matrix
Assignee: Medtronic Inc
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Filing: 1997-05-12
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Granted: —
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Expires: 2017-05-12
Abstract
Abstract A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
Inventors
- 👤 Marc Hendriks
- 👤 Michel Verhoeven
- 👤 Linda L. Cahalan
- 👤 Patrick T. Cahalan
- 👤 Benedicte Fouache
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 07:40
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/12; A61L33/128; A61L27/00; A61L27/14; A61L27/22; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L29/00; A61L29/04; A61L29/044; A61L29/08; A61L29/085; A61L29/14; A61L29/16; A61L31/00; A61L31/04; A61L31/043; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/0041; A61L33/0076; A61L33/0088; A61L2300/00; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
54 words
A medical device comprising: a) a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and b) one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix.
Claim 2
Dependent Claim
27 words
A device according to claim 1, wherein a majority of the biomolecules are located within about 10 nm of the outer surface of the surface graft matrix.
Claim 3
Dependent Claim
67 words
A medical device comprising: a) a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; b) one or more linker molecules covalently coupled to the surface graft matrix, wherein a majority of the linker molecules are located in the outer portion of the surface graft matrix; and c) one or more biomolecules covalently coupled to the linker molecules.
Claim 4
Dependent Claim
28 words
A device according to claim 3, wherein a majority of the linker molecules are located within about 10 nm of the outer surface of the surface graft matrix.
Claim 5
Dependent Claim
18 words
A device according to claim 3 or 4, wherein the linker molecules, prior to coupling, are amine-functional compounds.
Claim 6
Dependent Claim
22 words
A device according to claim 5, wherein the amine-functional compounds are selected from the group consisting of polyethyleneimine, polyallylamine, and mixtures thereof.
Claim 7
Independent Claim
42 words
A device according to any preceding claim, wherein the one or more biomolecules is selected from the group consisting of antithrombotic agents, antibacterial agents, anti-inflammatory agents, growth factors, cytokines, naturally occurring or synthetically prepared proteins, peptides, and amino acids, and mixtures thereof.
Claim 8
Independent Claim
63 words
A device according to any preceding claim, wherein the one or more biomolecules is selected from the group consisting of collagen, albumin, fibrinogen, laminin, vitronectin, fibronectin, RGD-containing peptides, heparin, heparin sulfate, fibroblast growth factors (FGF), insulin-like growth factor, nerve growth factor, interferons (IFN), tumor necrosis factors (TNF), interleukins, gelatin, elastin, fibrin, von Willebrand factor, dermatan sulfate, hyaluronic acid, dextran sulfate, and mixtures thereof.
Claim 9
Independent Claim
44 words
A device according to any preceding claim, wherein the surface graft matrix is prepared from carboxyl-functional monomers selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, trans-cinnamic acid, crotonic acid, linoleic acid, linolenic acid, maleic acid, sorbic acid, and mixtures thereof.
Claim 10
Independent Claim
27 words
A device according to any of claims 1 to 8, wherein the surface graft matrix is prepared from carboxyl-functional monomers and vinyl monomers having no carboxyl functionality.
Claim 11
Dependent Claim
20 words
A device according to claim 10, wherein the surface graft matrix is prepared from acrylic acid monomers and acrylamide monomers.
Claim 12
Independent Claim
17 words
A device according to any preceding claim, further including a pharmaceutical agent in the surface graft matrix.
Claim 13
Dependent Claim
55 words
A device according to claim 12, wherein the pharmaceutical agent is selected from the group consisting of antimicrobial agents, antibacterial agents, anticoagulant agents, antithrombotic agents, platelet agents, anti-inflammatory agents, dyes which act as biological ligands, steroids, enzymes, catalysts, hormones, growth factors, drugs, vitamins, antibodies, antigens, nucleic acids, peptides, DNA & RNA segments, and mixtures thereof.
Claim 14
Independent Claim
99 words
A method of modifying the surface of a medical device comprising: (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device; (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix; and (c) covalently coupling one or more biomolecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix.
Claim 15
Independent Claim
112 words
A method of modifying the surface of a medical device comprising: (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device; (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix; (c) covalently coupling one or more linker molecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the linker molecules are located in the outer portion of the surface graft matrix; and (d) covalently coupling one or more biomolecules to the linker molecules.
Claim 16
Dependent Claim
25 words
A method according to claim 14 or 15, wherein the pH of the solutions in steps b and c is no greater than about 5.5.
Claim 17
Dependent Claim
40 words
A method according to claim 14, 15 or 16, wherein the step of forming a surface graft matrix further comprises forming the surface graft matrix in a solution having a pH less than the pKa of the surface graft matrix.
Claim 18
Dependent Claim
30 words
A method according to claim 17, further comprising rinsing the formed surface graft matrix in an aqueous solution having a pH greater than the pKa of the surface graft matrix.
Claim 19
Independent Claim
42 words
A method according to any of claims 14 to 18, wherein the biomolecule is selected from the group consisting of antithrombotic agents, antibacterial agents, anti-inflammatory agents, growth factors, cytokines, naturally occurring or synthetically prepared proteins, peptides, and amino acids, and mixtures thereof.
Claim 20
Independent Claim
47 words
A method according to any of claims 14 to 19, wherein the surface graft matrix is formed from carboxyl-functional monomers selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, trans-cinnamic acid, crotonic acid, linoleic acid, linolenic acid, maleic acid, sorbic acid, and mixtures thereof.
Claim 21
Independent Claim
27 words
A method according to any of claims 14 to 19, wherein the surface graft matrix is formed from carboxyl-functional monomers and vinyl monomers having no carboxyl functionality.
Claim 22
Independent Claim
66 words
A method of delivering a pharmaceutical agent comprising contacting a body with a medical device comprising a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion in which a majority of one or more biomolecules are coupled, wherein the pharmaceutical agent is located within the surface graft matrix when the device is initially contacted with the body.
References Cited (Backward Citations)
No citation records indexed.
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