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EP0865763A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Apparatus for measuring volumes and global and segmental corporal composition in human beings

Assignee: NTE SA
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Filing: 1998-03-04
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Granted: —
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Expires: 2018-03-04
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Abstract

Abstract Apparatus and procedure for measuring volumes and global and segmental corporal composition in human beings, by means of measuring the electrical impedance at various frequencies, determining in this manner, the ratio between the intracellular water and the extracellular water volumes, the contents of total and extracellular water in each segment and the contents of the segmental lean mass. The apparatus is made up of a computer (11) which controls an electronic box (12), fed through a feeding source (14), various electrodes (13) coming out from said electronic box (12) which are placed on the body under research.

Inventors

  • 👤 Javier Rosell Ferrer
  • 👤 Jordi Elvira Canas
  • 👤 Pere Riu Costa
  • 👤 Ramon Bragos Bardia
  • 👤 Ramon Pallas Areny

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-10-30 14:10
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/48; A61B5/4869; A61B5/05; A61B5/053; A61B5/0537; A61B5/4872

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 609 words
Procedure for the measuring of volumes and global and segmental corporal composition in human beings, by means of measuring the electrical impedance at various frequencies, at least four, in the range comprised between 1 kHz to 1 MHz, in which a first estimation is conducted of the ratio between the total water and the extracellular water volumes by means of the k quotient between the impedance module at low frequency Z(BF), placed between 1 kHz and 50 kHz, and the impedance module at high frequency Z(AF), placed between 100 kHz to 10 MHz, said value k being independent from the conditions of the measurement contour, characterized in that an adjustment is made at the experimetal points by means of the least squares method, both at global and segmental level, by means of the following electrical impedance expression (Z) based on the frequency (f); Z (f) = R ∞ + R 0 - R ∞ 1 - 1-α j f f c thus determining the values R ∞ , R 0 , f c and α, which present the resistance at infinite frequency, the resistance at zero frequency, the frequency at which the maximum of Im(Z) occurrs and the dispersion of the cells of the biological system, respectively, with which the the following values are calculated: a) the ratio between the intracellular water and the extracellular water volumes, given by; E = R 0 - R∞ R∞ b) the total water content of a segment i (TBW seg,i ), given by: TBW seg,i = ko TBW seg,i + K TBW . H 2 . L 2 seg,i Real [Z(∞)] and the content of a segment i in extracellular water (ECW seg.i ) which is determined by: ECW seg,i = ko ECW seg,i + K ECW •H 2 •L' 2 seg,i real [Z(10 KHz )] H being the height of the body in cm, K TBW a constant of proportionality for the total water (TBW) and K ECW a constant of proportionality for the extracellular water, Ko TBW seg,i the independent term for segment i, Ko ECW seg,i , for the extracellular water (ECW) for segment i, L seg,i and L' seg,i are geometric terms to be determined for each segment i; corresponding the real value [Z (∞)] to the real value of an impedance over 100 kHz and below 1 MHz for segment i, but preferably at R∞, and the real value [Z(10 kHz)] the real value of an impedance over 10 kHz and below 50 kHz for segment i but preferably at R 0 ; c) the content of segment i in intracellular water which is determined by means of the subtraction of ECW seg,i from TBW seg,i . d) the volume of total and extracellular water at global level which shall be determined by the sum of the respective values of segments i e) the content of the segmental or regional MM seg,i and global lean mass by means of the equation MM seg,i = Lean Mass = N + M · D 2 eq,seg,i R(AF) N and M being terms which are introduced from the lineal regression between the ratio: D 2 seg,i Re [Z (∞)] and the value of the amount of lean mass measured by means of an alternative method and which depend on the type of human race, and D 2 eq,seg,i , a geometric parameter of segment i, obtaining the global value of the amount of lean mass from the sum of all the values MM seg,i and the global fatty mass from the difference between the weight of the human body studied and the weight of the amount of global lean matter.
Claim 2
Dependent Claim 43 words
Procedure according to claim 1, characterized in that the volumen of total and extracellular water at global level is determined using the RSI (right side impedance) as if it were a segment conveniently considering the specific parameters of the TBW and ECW formulas.
Claim 3
Dependent Claim 184 words
Apparatus for measuring the electrical impedance at various frequencies for the embodiment of the procedure according to the previous claims, characterized in that it consists of a backplane (15) which interconnects: an electrical source (20); a signal generator board (16) which generates at least two frequencies selected as well as reference signals for the demodulation; a board for patient interface (17) which converts the tension signals generated into current, a detection signal board (18) which is made up of a differential amplifier and a gain amplifier with selectable gains via software; an A/D obtention board (19) which is provided with an A/D convertor of 16 bits for sampling for data obtention; the current source (20) being connected to the body under study by means of a multiplexor which permits any pair of electrodes to be connected to the said source, connecting each one of the electrodes to an in-put buffer, whilst each one of their out-puts is connected to a multiplexor circuit which feeds a differential amplifier, by means of shielded coaxial cables; conducting the control of the system by means of a microcontroller.
Claim 4
Dependent Claim 35 words
Apparatus according to claim 3, characterized in that it is provided with an accelerometer which provides the acceleration measurement to which the body has been subjected to, in a synchronized manner with the impedance measure.

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