Claim 1
Independent Claim
609 words
Procedure for the measuring of volumes and
global and segmental corporal composition in human
beings, by means of measuring the electrical impedance
at various frequencies, at least four, in the range
comprised between 1 kHz to 1 MHz, in which a first
estimation is conducted of the ratio between the total
water and the extracellular water volumes by means of
the k quotient between the impedance module at low
frequency Z(BF), placed between 1 kHz and 50 kHz, and
the impedance module at high frequency Z(AF), placed
between 100 kHz to 10 MHz, said value k being independent
from the conditions of the measurement contour,
characterized in that an adjustment is made at the
experimetal points by means of the least squares method,
both at global and segmental level, by means of the
following electrical impedance expression (Z) based on
the frequency (f); Z (f) = R ∞ + R 0 - R ∞ 1 - 1-α j f f c thus determining the values R ∞ , R 0 , f c and α, which
present the resistance at infinite frequency, the resistance
at zero frequency, the frequency at which the
maximum of Im(Z) occurrs and the dispersion of the cells
of the biological system, respectively, with which the
the following values are calculated: a) the ratio between the intracellular water
and the extracellular water volumes, given by; E = R 0 - R∞ R∞ b) the total water content of a segment i
(TBW seg,i ), given by: TBW seg,i = ko TBW seg,i + K TBW . H 2 . L 2 seg,i Real [Z(∞)] and the content of a segment i in extracellular water
(ECW seg.i ) which is determined by: ECW seg,i = ko ECW seg,i + K ECW •H 2 •L' 2 seg,i real [Z(10 KHz )] H being the height of the body in cm, K TBW a constant of
proportionality for the total water (TBW) and K ECW a
constant of proportionality for the extracellular water,
Ko TBW seg,i the independent term for segment i, Ko ECW seg,i , for the extracellular water (ECW) for segment i,
L seg,i and L' seg,i are geometric terms to be determined
for each segment i; corresponding the real value [Z (∞)]
to the real value of an impedance over 100 kHz and below
1 MHz for segment i, but preferably at R∞, and the real
value [Z(10 kHz)] the real value of an impedance over 10
kHz and below 50 kHz for segment i but preferably at R 0 ; c) the content of segment i in intracellular
water which is determined by means of the subtraction of
ECW seg,i from TBW seg,i . d) the volume of total and extracellular water
at global level which shall be determined by the sum of
the respective values of segments i e) the content of the segmental or regional
MM seg,i and global lean mass by means of the equation MM seg,i = Lean Mass = N + M · D 2 eq,seg,i R(AF) N and M being terms which are introduced from the lineal
regression between the ratio: D 2 seg,i Re [Z (∞)] and the value of the amount of lean mass measured by
means of an alternative method and which depend on the
type of human race, and D 2 eq,seg,i , a geometric parameter
of segment i, obtaining the global value of the amount
of lean mass from the sum of all the values MM seg,i and
the global fatty mass from the difference between the
weight of the human body studied and the weight of the
amount of global lean matter.
Claim 3
Dependent Claim
184 words
Apparatus for measuring the electrical
impedance at various frequencies for the embodiment of
the procedure according to the previous claims, characterized
in that it consists of a backplane (15) which
interconnects: an electrical source (20); a signal
generator board (16) which generates at least two
frequencies selected as well as reference signals for
the demodulation; a board for patient interface (17)
which converts the tension signals generated into
current, a detection signal board (18) which is made up
of a differential amplifier and a gain amplifier with
selectable gains via software; an A/D obtention board
(19) which is provided with an A/D convertor of 16 bits
for sampling for data obtention; the current source (20)
being connected to the body under study by means of a
multiplexor which permits any pair of electrodes to be
connected to the said source, connecting each one of the
electrodes to an in-put buffer, whilst each one of their
out-puts is connected to a multiplexor circuit which
feeds a differential amplifier, by means of shielded
coaxial cables; conducting the control of the system by
means of a microcontroller.