Sustained release compound unit pharmaceutical

Abstract

Abstract PURPOSE:The titled highly safe and effective pharmaceutical obtained by adding an elution inhibitor to a mixture containing a physiologically active substance and a specific amount or more of a unit-forming material, e.g. crystalline cellu lose, etc., granulating the resultant mixture and forming the resultant granular material into a capsule or tablet. CONSTITUTION:The titled pharmaceutical, consisting of a granular material obtained by adding an elution inhibitor, e.g. an aqueous suspension of a water- insoluble high polymer such as methacrylic acid ethyl acrylate copolymer to a mixture of a physiologically active substance, particularly 5-[2[2-(0- ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide-hydrochlo ride, i.e. YM-12617 and >=50wt%, particularly >=70wt%, based on the unit, unit- forming material, preferably crystalline cellulose and granulating the resultant mixture in individual unit pharmaceutical and capable of slowly releasing the physiologically active substance without disintegrating the granular material in the digestive tracts.

Inventors

• 👤 Muneo Fukui
• 👤 福井　宗夫
• 👤 Koji Tomuro
• 👤 戸室　光司
• 👤 Shigeru Masuyama
• 👤 増山　茂
• 👤 Tokuji Kajiyama
• 👤 梶山　篤司
• 👤 Tamio Hikosaka
• 👤 彦坂　民夫
• 👤 Masayoshi Ariga
• 👤 有賀　政義
• 👤 Yoshiaki Soeishi
• 👤 添石　良晁
• 👤 Saburo Higuchi
• 👤 樋口　三郎

Bibliographic Details