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US2773875A
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Indole derivatives and method for producing same
Assignee: F Hoffmann La Roche AG
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Filing: 1952-03-28
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Granted: 1956-12-11
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Expires: 1972-03-28
Abstract
No abstract record available.
Inventors
- 👤 Finkelstein Jacob
- 👤 Lee John
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 06:18
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
91 words
A PROCESS WHICH COMPRISES REACTING THE SODIUM SALT OF ETHYL B-(2-PYRIDYL) ETHYLACETOACETATE WITH DIAZOTIZED ANILINE SO AS TO PRODUCE ETHYL A-KETO-Y-(2-PYRIDYL) BUTYRATE PHENYLHYDRAZONE, HEATING THE LATTER IN THE FORM OF ITS HYDROCHLORIDE IN THE PRESENCE OF SULFURIC ACID TO PRODUCE ETHYL 3-(2-PYRIDYLMETHYL)-2-INDOLECARBOXYLATE, SAPONIFYING THE HYDROCHLORIDE OF THE LAST MENTIONED COMPOUND TO PRODUCE 3-(2-PYRIDYLMETHYL)-2-INDOLYLBOXYLIC ACID, DECARBOXYLATING THE LATTER IN THE PRESENCE OF COPPER TO PRODUCE 3-(2-PYRIDYLMETHYL) INDOLE, REACTING THE LAST MENTIONED COMPOUND WITH A METHYLATING QUATERNIZING AGENT TO PRODUCE THE CORRESPONDING 2-(3-INDOLYLMETHYL) 1-METHYLPYRIDINIUM SALT, AND CATALYTICALLY REDUCING THE LATTER TO PRODUCE 3-(METHYL-2-PIPERIDYLMETHYL)INDOLE.
Claim 2
Dependent Claim
91 words
A PROCESS WHICH COMPRISES REACTING THE SODIUM SALT OF ETHYL B-(2-PYRIDYL) ETHYLACETOACETATE WITH DIAZOTIZED ANILINE SO AS TO PRODUCE ETHYL A-KETO-Y-(2-PYRIDYL) BUTYRATE PHENYLHYDRAZONE, HEATING THE LATTER IN THE FORM OF ITS HYDROCHLORIDE IN THE PRESENCE OF SULFURIC ACID TO PRODUCE ETHYL 3-(2-PYRIDYLMETHYL)-2-INDOLECARBOXYLATE, SAPONIFYING THE HYDROCHLORIDE OF THE LAST MENTIONED COMPOUND TO PRODUCE 3-(2-PYRIDYLMETHYL)-2-INDOLYLBOXYLIC ACID, DECARBOXYLATING THE LATTER IN THE PRESENCE OF COPPER TO PRODUCE 3-(2-PYRIDYLMETHYL) INDOLE, REACTING THE LAST MENTIONED COMPOUND WITH A METHYLATING QUATERNIZING AGENT TO PRODUCE THE CORRESPONDING 2-(3-INDOLYLMETHYL) 1-METHYLPYRIDINIUM SALT, AND CATALYTICALLY REDUCING THE LATTER TO PRODUCE 3-(METHYL-2-PIPERIDYLMETHYL)INDOLE.
References Cited (Backward Citations)
US673949A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1959-12-11 | 1960-06-11 | 1960-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1963-12-11 | 1964-06-11 | 1964-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1967-12-11 | 1968-06-11 | 1968-12-11 | $7700.00 | Window Closed / Lapsed |