Steroid carbonates and process
Abstract
Abstract THE INVENTION DISCLOSED HEREIN IS CONCERNED GENERALLY WITH NOVEL STEROID CARBONATES AND PROCESSES FOR PREPARING THEM. MORE PARTICULARLY, IT RELATES TO 17-ALKYL, ARYL AND ARALKYL) CARBONATE ESTERS OF 17A-HYDROXY-20-KETO-STEROIDS OF THE SATURATED AND UNSATURATED PREGNANE SERIES; AND WITH PROCESSES FOR PREPARING THESE SATURATED AND UNSATURATED 17A-HYDROXY-20-KETO-PREGNANE-17-CARBONATES BY FIRST REACTING THE FREE 17A-HYDROXY-STEROID WITH AN ORGANO METALLIC COMPOUND, AND THEN REACTING THE METAL 17-OLATE THUS PRODUCED WITH AN ALKYL CHLOROFORMATE, AND ARYL CHLOROFORMATE OR ARALKYL CHLOROFORMATE. THESE NEW 17A-HYDROXY-20 KETO-PREGNANE-17-(ALKYL, ARYL AND ARALKYL) CARBONATES POSSESS PROGESTATIONAL ACTIVITY AND ARE VALUABLE AS ESTERUS REGULATING AGENTS.
Inventors
- 👤 Lewis H Sarett
- 👤 Thomas B Windholz
Bibliographic Details
Claims Analysis
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