Patent US3607077A successfully refreshed from Google Patents.
US3607077A
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Compositions of agreeable odor for the determination of aldoses
Assignee: Merck Patent GmbH
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Filing: 1969-04-29
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Granted: 1971-09-21
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Expires: 1989-04-29
Abstract
Abstract To eliminate the obnoxious odor associated with the otoluidine-glacial acetic method of conducting aldose, especially blood glucose determinations, the color reagent is modified to include at least one hydroxycarboxylic acid, e.g. glycolic acid and little or no glacial acetic acid, there being no sacrifice in the reaction rate or in the yield of the resultant colored compound.
Inventors
- 👤 Arnold Hartel
- 👤 Roland Helger
- 👤 Hermann Lang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:43
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/66; Y; Y10; Y10T; Y10T436/00; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
17 words
A color reagent as defined by claim 1 wherein said hydroxy acid comprises a lower hydroxymonocarboxylic acid.
Claim 2
Dependent Claim
32 words
A color reagent as defined by claim 1, wherein said hydroxy acid comprises a member selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid and citric acid.
Claim 3
Dependent Claim
25 words
A color reagent as defined by claim 1 further comprising an inert hydroxy containing organic solvent having a boiling point of at least 90* C.
Claim 4
Dependent Claim
33 words
A color reagent as defined by claim 1 wherein, based on 100 parts by weight of total color reagent, said o-substituted, o''-unsubstituted aniline comprises 2-25 parts and said hydroxy acid comprises 5-90 parts.
Claim 5
Dependent Claim
40 words
In a method of conducting an aldose determination comprising the steps of mixing a color reagent with a liquid containing an aldose, and photometrically measuring the resultant color, the improvement comprising employing a color reagent as defined by claim 1.
Claim 6
Dependent Claim
23 words
A color reagent as defined by claim 1 wherein the said meta-and para-positions are satisfied by hydrogen or alkyl of 1-4 carbon atoms.
Claim 7
Dependent Claim
18 words
A color reagent as defined by claim 1 wherein the said meta-and para positions are satisfied by hydrogen.
Claim 8
Dependent Claim
17 words
A color reagent as defined by claim 1 comprising 10-20 parts by weight of glacial acetic acid.
Claim 9
Dependent Claim
40 words
In a method of conducting an aldose determination comprising the steps of mixing a color reagent with a liquid containing an aldose, and photometrically measuring the resultant color, the improvement comprising employing a color reagent as defined by claim 9.
Claim 10
Dependent Claim
17 words
A color reagent as defined by claim 1, containing zero parts by weight of glacial acetic acid.
Claim 11
Dependent Claim
40 words
In a method of conducting an aldose determination comprising the steps of mixing a color reagent with a liquid containing an aldose, and photometrically measuring the resultant coLor, the improvement comprising employing a color reagent as defined by claim 11.
Claim 12
Dependent Claim
15 words
A color reagent as defined by claim 1 wherein said o-substituted, o''-unsubstituted aniline is o-toluidine.
Claim 13
Dependent Claim
17 words
A color reagent as defined by claim 13 wherein said hydroxy acid comprises a lower hydroxymonocarboxylic acid.
Claim 14
Dependent Claim
42 words
A color reagent as defined by claim 13 wherein said hydroxy acid comprises a mixture selected from the group consisting of (1) malic and lactic acid, (2) malic and glycolic acids, (3) tartaric and lactic acids, and (4) tartaric and glycolic acids.
Claim 15
Dependent Claim
25 words
A color reagent as defined by claim 13 further comprising a solubilizer selected from the group consisting of a glycol and a monoalkyl glycol ether.
Claim 16
Dependent Claim
40 words
In a method of conducting an aldose determination comprising the steps of mixing a color reagent with a liquid containing an aldose, and photometrically measuring the resultant color, the improvement comprising employing a color reagent as defined by claim 13.
Claim 17
Dependent Claim
32 words
A color reagent as defined by claim 13 wherein said hydroxy acid comprises a member selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid and citric acid.
Claim 18
Dependent Claim
33 words
A color reagent as defined by claim 18 further comprising a solubilizer selected from the group consisting of ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol, propylene glycol and mixtures thereof.
Claim 19
Dependent Claim
40 words
In a method of conducting an aldose determination comprising the steps of mixing a color reagent with a liquid containing an aldose, and photometrically measuring the resultant color, the improvement comprising employing a color reagent as defined by claim 18.
Claim 20
Dependent Claim
33 words
A color reagent as defined by claim 18 wherein, based on 100 parts by weight of total color reagent, said o-substituted, 0''-unsubstituted aniline comprises 2-25 parts and said hydroxy acid comprises 5-90 parts.
Claim 21
Dependent Claim
40 words
In a method of conducting an aldose determination comprising the steps of mixing a color reagent with a liquid containing an aldose, and photometrically measuring the resultant color, the improvement comprising employing a color reagent as defined by claim 21.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1974-09-20 | 1975-03-22 | 1975-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1978-09-20 | 1979-03-22 | 1979-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1982-09-20 | 1983-03-22 | 1983-09-21 | $7700.00 | Window Closed / Lapsed |