Phenyl-thiazole-malonic acid derivatives

Abstract

Abstract THIAZOLE DERIVATIVES OF THE FORMULA: X,Y,Z-THIAZOLE WHEREIN Y OR Z IS LINKED TO THE 2-POSITION OF THE THIAZOLE NUCLEUS, X STANDS FOR HYDROGEN OR ALKYL OF UP TO 3 CARBONS, Y STANDS FOR A PHENYL RADICAL AND Z STANDS FOR A GROUP OF THE FORMULA: -C(-R1)(-COO-R3)-COO-R2 WHEREIN R1 STANDS FOR HYDROGEN, ALKALI METAL, ALKYL OF NOT MORE THAN 3 CARBONS, DIALKYLAMINOMETHYL OF NOT MORE THAN 5 CARBONS, N-PIPERIDINOMETHYL OR N-MORPHOLINOMETHYL, CHLORINE OR BROMINE, AND R2 AND R3, STANDS FOR HYDROGEN OR ALKYL RADICAL OF NOT MORE THAN 3 CARBONS, PROVIDED THAT WHEN R2 AND R3 STAND FOR HYDROGEN, R1 STANDS FOR HYDROGEN OR AN ALKYL RADICAL OF NOT MORE THAN 3 CARBON ATOMS, AND NON-TOXI PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF. THESE PHENYL-THIAZOLE-MALONIC ACID DERIVATIVES POSSES ANTI-INFLAMMATORY, ANALGESIC AND ANTI-PYRETIC ACTIVITY. PROCESSES FOR PREPARING THESE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME ARE DISCLOSED. A TYPICAL COMPOUNDS IS DIETHYL 4-(4-BROMOPHENYL)THIAZOL-2-YLMALONATE.

Inventors

• 👤 Walter Hepworth
• 👤 Gilbert Joseph Stacey

Bibliographic Details