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US3684791A
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N{11 {11 {11 {11 {11 {11 , n{11 {11 {11 {11 {11 {11 -di-tert. butyloxycarbonyl-insulin and process for its manufacture
Assignee: Hoechst AG
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Filing: 1969-09-22
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Granted: 1972-08-15
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Expires: 1989-09-22
Abstract
Abstract N (A1), N (B29)-di-tert. butyloxycarbonyl insulin, useful as a hypoglycemic agent. A method for its preparation by reacting insulin, in a mixture of an N,N''-dialkylcarboxylic acid amide having a total of from three to six carbon atoms and an aqueous buffer solution having a pH between 8.0 and 9.0, with a 20 to 75 fold molar excess of tert. butyloxycarbonyl azide at 20* to 50*C.
Inventors
- 👤 Rolf Geiger
- 👤 Werner Pfaff
- 👤 Alfred Bander
- 👤 Hans-Hermann Schone
- 👤 Adolf Mager
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:03
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/62; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 1
Claim 1
Independent Claim
67 words
A process for preparing N (Al), N (B29)-di-tert.-butyloxycarbonyl-insulin which comprises reacting insulin with a 20- to 75-fold molar excess of tert.-butyloxycarbonyl azide at 20*-50*C. in a mixture of an N,N-dialkyl alkanoic acid amide having from three to six carbon atoms and an aqueous buffer solution having a pH between 8.0 and 9.0 the amount of buffer being at least 2.5 times the amount of insulin, by weight.
References Cited (Backward Citations)
US3528960A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-08-15 | 1976-02-14 | 1976-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-08-15 | 1980-02-14 | 1980-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-08-15 | 1984-02-14 | 1984-08-15 | $7700.00 | Window Closed / Lapsed |