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2{8 (2-ALKYLBENZO{8 b{9 {11 FURAN-3 yl)METHYL{9 -{66 {11 IMIDAZOLINE

Assignee: Sanofi SA
•
Filing: 1972-01-10
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Granted: 1974-06-18
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Expires: 1992-01-10
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Abstract

Abstract 2-((2-Alkylbenzo(b)furan-3-yl)methyl)- Delta 2-imidazolines and salts thereof are peripheral vasoconstrictors useful for the relief of congestion of the nasal mucosa. They are produced from 2-alkylbenzo(b)furans by reaction with HCl and trioxane to form 2-alkyl-3-chloromethylbenzo(b)furans which are converted, by reaction with KCN in the presence of KI, to 2-alkyl-3cyanomethylbenzo(b)furans which, on treatment with HCl in alcohol, produce the desired imidazoline derivatives.

Inventors

  • 👤 F Binon
  • 👤 A Areschka

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 21:47
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D405/00; C07D405/02; C07D405/06

Claims Analysis

Total Claims: 1
Claim 1
Independent Claim 11 words
A compound as defined by claim 1 wherein R is ethyl.

References Cited (Backward Citations)

US3161653A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1977-06-17 1977-12-17 1978-06-18 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1981-06-17 1981-12-17 1982-06-18 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1985-06-17 1985-12-17 1986-06-18 $7700.00 Window Closed / Lapsed

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