Patent US3843656A successfully refreshed from Google Patents.
US3843656A
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2-methylamino-4'-methyl-4-piperazinyl-6-chloro-5-methylthio-pyrimidine,salts thereof,and process for their preparation
Assignee: Produits Chimiques Ugine Kuhlmann
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Filing: 1973-03-01
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Granted: 1974-10-22
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Expires: 1993-03-01
Abstract
Abstract The compound of the formula: SALTS OF THIS COMPOUND AND PROCESS FOR THE PREPARATION OF THE COMPOUND WHICH COMPRISES CONDENSING ONE MOLE OF 2,4,6-TRICHLORO5-METHYLTHIO-PYRIMIDINE WITH 1 MOLE OF METHYLAMINE AT A TEMPERATURE EQUAL TO OR LESS THAN THE ORDINARY ROOM TEMPERATURE AND CONDENSING THE 2-METHYLAMINO-4,6-DICHLORO-5-METHYLTHIOPYRIMIDINE THUS OBTAINED WITH ONE MOLE OF N-methylpiperazine to yield 2-methylamino-4''-methyl-4-piperazinyl-6-chloro-5methylthio-pyrimidine and medicaments consisting of or comprising this compound or a pharmaceutically acceptable salt thereof, said medicaments having action on the central nervous system.
Inventors
- 👤 P Obellianne
- 👤 R Millischer
- 👤 P Carbonnel
- 👤 G Loiseau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:30
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/47; A; A61; A61P; A61P25/00; C07D239/48
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
5 words
THE COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
THE COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
9 words
A salt of the compound claimed in claim 1.
Claim 4
Dependent Claim
49 words
Process for the preparation of the compound claimed in claim 1 which comprises condensing 1 mole of 2,4,6-trichloro-5-methylthio-pyrimidine with 1 mole of methylamine at a temperature equal to or less than the ordinary room temperature and condensing the 2-methylamino-4,6-dichloro-5-methylthio-pyrimidine thus obtained with one mole of N-methylpiperazine to yield 2-methylamino-4''-methyl-4-piperazinyl-6-chloro-5-methylthio-pyrimidine.
Claim 5
Dependent Claim
13 words
Process according to claim 3 wherein the 2-methylamino-4''-methyl-4-piperazinyl-6-chloro-5-methylthio-pyrimidine is reacted with an acid.
Claim 6
Dependent Claim
10 words
Process according to claim 3 wherein the 2-methylamino-4,6-dichloro-5-methylthio-pyrimidine is isolated.
Claim 7
Dependent Claim
20 words
Process according to claim 3 wherein the condensation with the methylamine is effected at a temperature from 0* to 10*C.
Claim 8
Dependent Claim
18 words
Process according to claim 6 wherein the condensation is effected in the presence of an alkali metal hydroxide.
Claim 9
Dependent Claim
25 words
Process according to claim 6 wherein the reaction medium for the condensation is a mixture of water and an organic solvent partly soluble in water.
Claim 10
Dependent Claim
18 words
Process according to claim 3 wherein the condensation with the N-methyl piperazine is effected in an alcoholic medium.
Claim 11
Dependent Claim
30 words
Process according to claim 3 wherein each of the condensations is effected in the presence of a tertiary base or an excess of the amine taking part in the condensation.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-10-21 | 1978-04-22 | 1978-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-10-21 | 1982-04-22 | 1982-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-10-21 | 1986-04-22 | 1986-10-22 | $7700.00 | Window Closed / Lapsed |