Patent US3859237A successfully refreshed from Google Patents.
US3859237A
Expired / Lapsed
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Quinazoline derivatives
Assignee: Sumitomo Chemical Co Ltd
•
Filing: 1972-11-07
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Granted: 1975-01-07
•
Expires: 1992-11-07
Abstract
Abstract Quinazoline derivatives represented by the formula WHEREIN R1 and R2 are individually a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, a lower alkylthio group or a lower alkylsulfonyl group; R3 is a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, a naphthyl group, a furyl group or a thienyl group; R4 is a lower cycloalkyl group or a trihalomethyl group; and n is an integer of 1 to 3, are novel compounds and have excellent pharmacological properties, particularly as anti-inflammatory and analgesic effects with low toxicity. They can be prepared by treating with ammonia a trihaloacetamidophenylketone derivative of the formula WHEREIN R1, R2 and R3 are as defined above: R is a hydrogen atom or a group of the formula -CnH2n-R4; and X is a halogen atom.
Inventors
- 👤 Shigeho Inaba
- 👤 Michihiro Yamamoto
- 👤 Kikuo Ishizumi
- 👤 Kazuo Mori
- 👤 Masao Koshiba
- 👤 Hisao Yamamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:04
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; C07D239/00; C07D239/70; C07D239/72; C07D239/78; C07D239/80; C07D239/82; C07D409/00; C07D409/02; C07D409/04
Claims Analysis
Total Claims: 65
Claim 1
Independent Claim
7 words
A QUINAZOLINE DERIATIVE REPRESENTED BY THE FORMULA
Claim 2
Dependent Claim
7 words
A QUINAZOLINE DERIATIVE REPRESENTED BY THE FORMULA
Claim 3
Dependent Claim
27 words
The quinazoline derivative according to claim 1, wherein R1, R2, R3 and n are as defined in claim 1; and R4 is a C3 6 cycloalkyl group.
Claim 4
Dependent Claim
31 words
The quinazoline derivative according to claim 2, wherein R1 and R2 are as defined in claim 1; R3 is a thienyl group; R4 is a cyclopropyl group; and n is 1.
Claim 5
Dependent Claim
32 words
The quinazoline derivative according to claim 1, wherein R4 is a trihalomethyl group; R3 is a thienyl or lower cycloalkyl group; and R1, R2 and n are as defined in claim 1.
Claim 6
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 7
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 8
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-chloro-2(1H)-qUinazolinone.
Claim 9
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-chloro-2(1H)-qUinazolinone.
Claim 10
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methyl-2(1H)-quinazolinone.
Claim 11
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methyl-2(1H)-quinazolinone.
Claim 12
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-7-methyl-2(1H)-quinazolinone.
Claim 13
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-7-methyl-2(1H)-quinazolinone.
Claim 14
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6,7-dimethyl-2(1H)-quinazolinone.
Claim 15
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6,7-dimethyl-2(1H)-quinazolinone.
Claim 16
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methoxy-2(1H)-quinazolinone.
Claim 17
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methoxy-2(1H)-quinazolinone.
Claim 18
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-8-methoxy-2(1H)-quinazolinone.
Claim 19
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-8-methoxy-2(1H)-quinazolinone.
Claim 20
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methoxy-8-methyl-2(1H)-quinazolinone.
Claim 21
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methoxy-8-methyl-2(1H)-quinazolinone.
Claim 22
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 23
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 24
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methylthio-2(1H)-quinazolinone.
Claim 25
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methylthio-2(1H)-quinazolinone.
Claim 26
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methyl-sulfonyl-2(1H)-quinazolinone.
Claim 27
Dependent Claim
1 words
1-Cyclopropylmethyl-4-(2''-thienyl)-6-methyl-sulfonyl-2(1H)-quinazolinone.
Claim 28
Dependent Claim
1 words
1-(2''-Cyclopropylethyl)-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 29
Dependent Claim
1 words
1-(2''-Cyclopropylethyl)-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 30
Dependent Claim
1 words
1-Cyclohexylmethyl-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 31
Dependent Claim
1 words
1-Cyclohexylmethyl-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 32
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-cyclohexyl-2(1H)-quinazolinone.
Claim 33
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-cyclohexyl-2(1H)-quinazolinone.
Claim 34
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-cyclohexyl-6-methoxy-2(1H)-quinazolinone.
Claim 35
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-cyclohexyl-6-methoxy-2(1H)-quinazolinone.
Claim 36
Dependent Claim
2 words
1-(2'',2'' ,2''-Trifluoroethyl)-4-cyclohexyl-6-nitro-2(1H)-quinazolinone.
Claim 37
Dependent Claim
2 words
1-(2'',2'' ,2''-Trifluoroethyl)-4-cyclohexyl-6-nitro-2(1H)-quinazolinone.
Claim 38
Dependent Claim
2 words
1-(2'',2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 39
Dependent Claim
2 words
1-(2'',2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 40
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-6-chloro-2(1H)-quinazolinone.
Claim 41
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-6-chloro-2(1H)-quinazolinone.
Claim 42
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-6-methyl-2(1H)-quinazolinone.
Claim 43
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-6-methyl-2(1H)-quinazolinone.
Claim 44
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-7-methyl-2(1H)-quinazolinone.
Claim 45
Dependent Claim
3 words
1-(2'' ,2'' ,2''-Trifluoroethyl)-4-(2''-thienyl)-7-methyl-2(1H)-quinazolinone.
Claim 46
Dependent Claim
1 words
1(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-8-methyl-2(1H)-quinazolinone.
Claim 47
Dependent Claim
1 words
1(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-8-methyl-2(1H)-quinazolinone.
Claim 48
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-methoxy-2(1H)-quinazolinone.
Claim 49
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-methoxy-2(1H)-quinazolinone.
Claim 50
Dependent Claim
2 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6,7-dimethoxy-2(1H) -quinazolinone.
Claim 51
Dependent Claim
2 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6,7-dimethoxy-2(1H) -quinazolinone.
Claim 52
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 53
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 54
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-methylthio-2(1H)-quinazolinone.
Claim 55
Dependent Claim
1 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-methylthio-2(1H)-quinazolinone.
Claim 56
Dependent Claim
2 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-methylsulfonyl-2(1H) -quinazolinone.
Claim 57
Dependent Claim
2 words
1-(2'',2'',2''-Trifluoroethyl)-4-(2''-thienyl)-6-methylsulfonyl-2(1H) -quinazolinone.
Claim 58
Dependent Claim
1 words
1-(2'',2'',2''-Trichloroethyl)-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 59
Dependent Claim
1 words
1-(2'',2'',2''-Trichloroethyl)-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 60
Dependent Claim
2 words
1-(2'' ,2'',2''-Trichloroethyl)-4-(2''-thienyl)-6-methoxy-2(1H)-quinazolinone.
Claim 61
Dependent Claim
2 words
1-(2'' ,2'',2''-Trichloroethyl)-4-(2''-thienyl)-6-methoxy-2(1H)-quinazolinone.
Claim 62
Dependent Claim
1 words
1-(2'',2'',2''-Trichloroethyl)-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 63
Dependent Claim
1 words
1-(2'',2'',2''-Trichloroethyl)-4-(2''-thienyl)-6-nitro-2(1H)-quinazolinone.
Claim 64
Dependent Claim
1 words
1-(2''-Chloro-2'',2''-difluoroethyl)-4-(2''-thienyl)-2(1H)-quinazolinone.
Claim 65
Dependent Claim
1 words
1-(2''-Chloro-2'',2''-difluoroethyl)-4-(2''-thienyl)-2(1H)-quinazolinone.
References Cited (Backward Citations)
US3549635A
Cited
US3551427A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-01-06 | 1978-07-08 | 1979-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-01-06 | 1982-07-08 | 1983-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-01-06 | 1986-07-08 | 1987-01-07 | $7700.00 | Window Closed / Lapsed |