Abstract A process for preparing a wide-pore adsorbent adapted for use in chromatography, comprising mixing finely dispersed non-porous silica having a specific surface area S of 35 to 380 m2/g with water followed by drying the aqueous suspension at a temperature within the range of 100 to 450*C to give a silica xerogel and particulating thereof. The xerogel, prior to particulation or thereafter, is subjected to the hydrothermal treatment in an autoclave at a temperature within the range of from 100 to 380*C and under a pressure of 1 to 300 atm., followed by drying at a temperature of 100 to 300*C. The above-described process makes possible the preparation of an adsorbent with larger pores as compared to adsorbents prepared from finely dispersed non-porous silica and produced by conventional processes. The process according to the present invention makes it possible to produce an adsorbent having a specific surface area within the range of from 2 to 280 m2/g and an average pore diameter of from 230 to 30,000 A, while retaining a high pore volume of 0.9 to 1.9 cm3/g. Such adsorbent is useful in chromatography for the purposes of separation, purification and analysis of a wide range of substances: from low- and moderately-boiling compounds up to polymers, and more particularly, biopolymers, and viruses.
A PROCESS OF PREPARING A POROUS SILICA ADSORBENT ADAPTED FOR USE IN CHROMATORGRAPHY COMOMPRISING THE STEPS OF (1) MIXING FINELY DISPERSED NON-POROUS SILICA HAVING A SPECIFIC SURFACE AREA OF 35 TO 380 M2/G WITH WATER TO FORM AN AQUEOUS SUSPENSION; (2) SPRAY DRYING THE SUSPENSION AT A TEMPERATURE OF 400* TO 450*C. TO FORM A PARTICULATED SILICA XEROGEL; (3) HYDROTHERMALLY TREATING THE XEROGEL AT A TEMPERATURE OF 100* TO 380*C. AND A PRESSURE OF 1 TO 300 ATM.; AND (4) DRYING THE TREATED XEROGEL AT A TEMPERATURE OF 100* TO 300*C.
Claim 2
Dependent Claim
91 words
A PROCESS OF PREPARING A POROUS SILICA ADSORBENT ADAPTED FOR USE IN CHROMATORGRAPHY COMOMPRISING THE STEPS OF (1) MIXING FINELY DISPERSED NON-POROUS SILICA HAVING A SPECIFIC SURFACE AREA OF 35 TO 380 M2/G WITH WATER TO FORM AN AQUEOUS SUSPENSION; (2) SPRAY DRYING THE SUSPENSION AT A TEMPERATURE OF 400* TO 450*C. TO FORM A PARTICULATED SILICA XEROGEL; (3) HYDROTHERMALLY TREATING THE XEROGEL AT A TEMPERATURE OF 100* TO 380*C. AND A PRESSURE OF 1 TO 300 ATM.; AND (4) DRYING THE TREATED XEROGEL AT A TEMPERATURE OF 100* TO 300*C.
Claim 3
Dependent Claim
39 words
A process according to claim 1 further comprising the step of calcining the silica xerogel in an atmosphere of steam or air at a temperature of from 550* to 1000*C. after either or both of steps (2) and (4).