US3917864A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of prostaglandins E and F for induction of labor
Assignee: Individual
•
Filing: 1974-06-20
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Granted: 1975-11-04
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Expires: 1994-06-20
Abstract
Abstract Methods are provided for inducing labor in gestating mammals, including humans and valuable warm-blooded animals such as horses, cows, monkeys and pigs by systemically administering to a gestating mammal a pharmaceutical dosage unit form supplying an effective nontoxic amount for inducing labor of a member selected from the group consisting of PGE1, PGE2, PGE3, dihydro-PGE, PGF1 , PGF2 , PGF3 , dihydro-PGF1 , PGF1 , PGF2 , PGF3 , dihydroPGF1 , pharmaceutically-acceptable salts thereof, pharmaceutically-acceptable acylates thereof wherein the acyl radical is that of a lower alkanoic acid having 1 to 8 carbon atoms, inclusive and pharamaceutically-acceptable carboxylate esters thereof wherein the esterifying radical has 1 to 8 carbon atoms, inclusive.
Inventors
- 👤 Sultanali M M Karim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:15
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
110 words
A METHOD OF INDUCING LABOR AND DELIVERY IN A GESTATING MAMMAL AT OR NEAR TERM WHICH CONSISTS ESSENTIALLY OF ADMINISTERING SYSTEMICALLY TO A SAID MAMMAL''A PHARMACEUTICAL DOSAGE UNIT FORM SUPPLYING AN EFFECTIVE NONTOXIC AMOUNT FOR INDUCING LABOR AND DELIVERY OF A PROSTAGLANDIN SELECTED FROM THE GROUP CONSISTING OF PGE1, PGE2, PGE3, DIHYDRO-PGE1, PGF1A, PGF2A, PFG2A, PGF3A, DIHYDRO-PGF1A, PGF1B, PGF2B, PGF3B, DIHYDRO-PGF1B, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PHARMACEUTICALLY ACCEPTABLE ACYLATES THEREOF WHEREIN ALL HYDROXXY GROUPS ARE ACYLATED AND THE ACYL RADICAL IS THAT OF A LOWER ALKANOIC ACID HAVING 1 TO 8 CARBON ATOMS, INCLUSIVE AND PHARMACEUTICALLY ACCEPTABLE ALKYL ESTERS THEREOF WHEREIN THE ALKYL RADICAL HAS 1 TO 8 CARBON ATOMS, INCLUSIVE.
Claim 2
Independent Claim
110 words
A METHOD OF INDUCING LABOR AND DELIVERY IN A GESTATING MAMMAL AT OR NEAR TERM WHICH CONSISTS ESSENTIALLY OF ADMINISTERING SYSTEMICALLY TO A SAID MAMMAL''A PHARMACEUTICAL DOSAGE UNIT FORM SUPPLYING AN EFFECTIVE NONTOXIC AMOUNT FOR INDUCING LABOR AND DELIVERY OF A PROSTAGLANDIN SELECTED FROM THE GROUP CONSISTING OF PGE1, PGE2, PGE3, DIHYDRO-PGE1, PGF1A, PGF2A, PFG2A, PGF3A, DIHYDRO-PGF1A, PGF1B, PGF2B, PGF3B, DIHYDRO-PGF1B, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PHARMACEUTICALLY ACCEPTABLE ACYLATES THEREOF WHEREIN ALL HYDROXXY GROUPS ARE ACYLATED AND THE ACYL RADICAL IS THAT OF A LOWER ALKANOIC ACID HAVING 1 TO 8 CARBON ATOMS, INCLUSIVE AND PHARMACEUTICALLY ACCEPTABLE ALKYL ESTERS THEREOF WHEREIN THE ALKYL RADICAL HAS 1 TO 8 CARBON ATOMS, INCLUSIVE.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein the gestating mammal is a human.
Claim 4
Dependent Claim
16 words
The method of claim 2 wherein the prostaglandin is PGE2 or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
14 words
The method of claim 2 wherein the prostaglandin is an alkyl ester of PGE2.
Claim 6
Dependent Claim
16 words
The method of claim 2 wherein the prostaglandin is PGF2 or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
15 words
The method of claim 2 wherein the prostaglandin is an alkyl ester of PGF2 .
Claim 8
Dependent Claim
31 words
The method of claim 2 wherein the effective, nontoxic amount for inducing labor and delivery is administered orally within a period of from about 28 weeks of pregnancy to about post-term.
Claim 9
Dependent Claim
16 words
The method of claim 7 wherein the prostaglandin is PGE2 or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
14 words
The method of claim 7 wherein the prostaglandin is an alkyl ester of PGE2.
Claim 11
Dependent Claim
16 words
The method of claim 7 wherein the prostaglandin is PGF2 or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
15 words
The method of claim 7 wherein the prostaglandin is an alkyl ester of PGF2 .
Claim 13
Dependent Claim
31 words
The method of claim 2 wherein the effective, nontoxic amount for inducing labor and delivery is administered intravenously within a period of from about 28 weeks of pregnancy to about post-term.
Claim 14
Dependent Claim
16 words
The method of claim 12 wherein the prostaglandin is PGE2 or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
14 words
The method of claim 12 wherein the prostaglandin is an alkyl ester of PGE2.
Claim 16
Dependent Claim
16 words
The method of claim 12 wherein the prostaglandin is PGF2 or a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim
15 words
The method of claim 12 wherein the prostaglandin is an alkyl ester of PGF2 .
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-03 | 1979-05-05 | 1979-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-03 | 1983-05-05 | 1983-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-03 | 1987-05-05 | 1987-11-04 | $7700.00 | Window Closed / Lapsed |