Patent US3926738A successfully refreshed from Google Patents.
US3926738A
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Method and apparatus for control of biochemical processes
Assignee: Individual
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Filing: 1972-05-10
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Granted: 1975-12-16
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Expires: 1992-05-10
Abstract
Abstract Biochemical processes are controlled by detecting a plurality of selected controllable variables and dependent variables and actuating controllers for maintaining said controllable variables within predetermined tolerance values in response to said detected controllable variable values and a time profile of each of said tolerance limits. On-line, real-time computer calculations are performed to determine the status of said process from said detected dependent and controllable variable values. Said controllers may be manually or automatically actuated in response to said calculated status, or the timeprofiles of the tolerance values may be automatically or manually adjusted in response to said calculated status.
Inventors
- 👤 Laszlo P Nyiri
- 👤 Arthur E Humphrey
- 👤 Iii Clyde S Harmes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 19:27
CPC Classifications
G; G05; G05D; G05D27/00; G05D27/02; B; B01; B01J; B01J19/00; B01J19/0006; B01J19/18; C; C12; C12M; C12M41/00; C12M41/26; C12M41/30; C12M41/32; C12M41/48; G01; G01N; G01N33/00; G01N33/48; B01J2219/00; B01J2219/00049; B01J2219/00051; B01J2219/00054; B01J2219/00056; B01J2219/00058; B01J2219/00162; B01J2219/00164; B01J2219/00177; B01J2219/00189
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
122 words
AN APPARARTUS FOR CONTROL OF BIOCHEMICAL PROCESSES COMPRISING VESSEL MEANS WITHIN WHICH SAID PROCESS IS TO BE PERFORMED; MEANS FOR ADDING CONTROLLED AMOUNTS OF SUBSTANCES REQUIRED FOR SAID PROCESS INTO SAID VESSEEL MEANS; MEANS FOR MONITORING A PLURALITY OF PREDETERMINED CONTROLLABLE AND DEPENDENT VARIABLES IN SAID PROCESS; CALCULATING MEANS FOR CALCULATING AT LEAST ONE FURTHER, NOT DIRECTLY MEASURABLE DEPENDENT VARIABLE REPRESENTATIVE OF THE STATUS OF THE BIOCHEMICAL PROCESS ON A REAL-TIME, ON-LINE BASIS FROM SAID DETECTED CONTROLLABLE AND DEPENDENT VARIABLES; AND CONTROL MEANS FOR INTERACTIVELY REGULATING THE VALUES OF SAID CONTROLLABLE VARIABLES IN RESPONSE TO SAID CALCULATED VALUES OF SAID FURTHER DEPENDENT VVARIABLE TO BRING SAID FURTHER DEPENDENT VARIABLE TO PREDETERMINED LEVELS TO CREATE THE DESIRED ENVIRONMENTAL CONDITIONS FOR THE BIOCHEMICAL PROCESS.
Claim 2
Dependent Claim
122 words
AN APPARARTUS FOR CONTROL OF BIOCHEMICAL PROCESSES COMPRISING VESSEL MEANS WITHIN WHICH SAID PROCESS IS TO BE PERFORMED; MEANS FOR ADDING CONTROLLED AMOUNTS OF SUBSTANCES REQUIRED FOR SAID PROCESS INTO SAID VESSEEL MEANS; MEANS FOR MONITORING A PLURALITY OF PREDETERMINED CONTROLLABLE AND DEPENDENT VARIABLES IN SAID PROCESS; CALCULATING MEANS FOR CALCULATING AT LEAST ONE FURTHER, NOT DIRECTLY MEASURABLE DEPENDENT VARIABLE REPRESENTATIVE OF THE STATUS OF THE BIOCHEMICAL PROCESS ON A REAL-TIME, ON-LINE BASIS FROM SAID DETECTED CONTROLLABLE AND DEPENDENT VARIABLES; AND CONTROL MEANS FOR INTERACTIVELY REGULATING THE VALUES OF SAID CONTROLLABLE VARIABLES IN RESPONSE TO SAID CALCULATED VALUES OF SAID FURTHER DEPENDENT VVARIABLE TO BRING SAID FURTHER DEPENDENT VARIABLE TO PREDETERMINED LEVELS TO CREATE THE DESIRED ENVIRONMENTAL CONDITIONS FOR THE BIOCHEMICAL PROCESS.
Claim 3
Dependent Claim
21 words
An apparatus as recited in claim 1, wherein said biochemical process is performed by one or more cellbound and/or cellfree enzymes.
Claim 4
Dependent Claim
32 words
An apparatus as recited in claim 1, wherein said monitoring means includes means for monitoring temperature, pH, concentration and ratio of substrates and precursors, dissolved oxygen and dissolved carbon dioxide (HCO3 ).
Claim 5
Dependent Claim
27 words
An apparatus as recited in claim 1, wherein said calculating means is adapted to calculate further state variables representative of the rheological conditions of the culture liquid.
Claim 6
Dependent Claim
26 words
An apparatus as recited in claim 1, wherein said calculating means is adapted to calculate further state variables representative of the physiological status of the process.
Claim 7
Dependent Claim
26 words
An apparatus as recited in claim 1, wherein said calculating means is adapted to calculate further state variables representative of the biochemical status of the process.
Claim 8
Dependent Claim
14 words
An apparatus as recited in claim 1, wherein said process is a fermentation process.
Claim 9
Dependent Claim
31 words
An apparatus as recited in claim 1, wherein said monitoring means includes means for periodically physically sampling the contents of said vessel means and performing on-line, real-time analysis of said samples.
Claim 10
Dependent Claim
54 words
An apparatus as recited in claim 1, wherein said control means is adapted for the regulation of said controllable variables in accordance with time profiles of tolerance values in response to detected controllable variable values and includes means for automatically setting said time profile tolerance values in response to said calculated further state values.
References Cited (Backward Citations)
US3586605A
Cited
US3684702A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-15 | 1979-06-16 | 1979-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-15 | 1983-06-16 | 1983-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-15 | 1987-06-16 | 1987-12-16 | $7700.00 | Window Closed / Lapsed |