Abstract The present invention relates to pharmacologically valuable new benzophenone derivatives having a pronounced sedative action on the central nervous system and some of which also possess muscle-relaxing and aggression-inhibiting properties. These new derivatives have the structural formula ##EQU1## and their acid addition salts, in which R 1 and R 2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1-4 carbon atoms; R 3 is a substituent selected from the group consisting of --CN, --CONH 2 , --COOCH 3 , --COOC 2 H 5 , --COOH, and --COOMe, where Me is a metallic cation; n is an integer selected from 1 and 2; and m is an integer selected from 1,2, and 3, and wherein the rings A and B may be substituted, ring A being substituted preferably with a halogen such as chlorine or with nitro, trifluoromethyl, methyl, methoxy or methylmercapto, preferably in the 5 position, and ring B being preferably substituted in the 2' position with chlorine or fluorine. The radicals R 1 and R 2 preferably signify hydrogen or a methyl group, or a n-butyl group in the case of Ring B.
Inventors
👤 Heinz Gunter Greve
👤 Klaus Resag
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-11-01 07:00
CPC Classifications
C; C07; C07C; C07C255/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
113 words
Benzophenone derivative having the structural formula ##EQU8## and the acid addition salts thereof, wherein R 1 and R 2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1 - 4 carbon atoms; R 3 is --CONH 2 ; n is an integer selected from 1 and 2; and m is an integer selected from 1, 2 and 3, and wherein the ring A is substituted at the 5-position with a substituent selected from the group consisting of halogen, nitro, trifluoromethyl, methyl, methoxy and methylmercapto and the ring B is substituted at the 2' position with a substituent selected from the group consisting of fluorine and chlorine.
Claim 2
Dependent Claim
113 words
Benzophenone derivative having the structural formula ##EQU8## and the acid addition salts thereof, wherein R 1 and R 2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1 - 4 carbon atoms; R 3 is --CONH 2 ; n is an integer selected from 1 and 2; and m is an integer selected from 1, 2 and 3, and wherein the ring A is substituted at the 5-position with a substituent selected from the group consisting of halogen, nitro, trifluoromethyl, methyl, methoxy and methylmercapto and the ring B is substituted at the 2' position with a substituent selected from the group consisting of fluorine and chlorine.
Claim 3
Dependent Claim
37 words
Benzophenone derivative according to claim 1, wherein R 1 is a substituent selected from the group consisting of hydrogen and methyl and R 2 is a substituent selected from the group consisting of hydrogen, methyl and butyl.