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Fluorene derivatives

Assignee: John Wyeth and Brother Ltd
•
Filing: 1975-11-04
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Granted: 1976-07-27
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Expires: 1995-11-04
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Abstract

Abstract The invention relates to fluorene derivatives of the formula AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS. In the formula R1, R2, R3 and R4 each represent hydrogen, hydroxyl, lower alkyl, lower alkoxy or halogen, R5 and R6 each represent hydrogen or lower alkyl and n represents 1 or 2. The compounds have hypoglycaemic activity.

Inventors

  • 👤 Alan Chapman White
  • 👤 Robin Michael Black

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 17:47
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/06; C07D233/00; C07D233/04; C07D233/06; C07C; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/06; C07C2603/10; C07C2603/12; C07C2603/18

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 74 words
A compound selected from the group consisting of a fluorene derivative of formula ##SPC9##and a pharmaceutically acceptable acid addition salt thereof, wherein R 1 , R 2 , R 3 and R 4 each represents a member from the group consisting of hydrogen, hydroxyl, lower alkyl, lower alkoxy and halogen, R 5 and R 6 each represents a member from the group consisting of hydrogen and lower alkyl and n represents 1 or 2.
Claim 2
Dependent Claim 74 words
A compound selected from the group consisting of a fluorene derivative of formula ##SPC9##and a pharmaceutically acceptable acid addition salt thereof, wherein R 1 , R 2 , R 3 and R 4 each represents a member from the group consisting of hydrogen, hydroxyl, lower alkyl, lower alkoxy and halogen, R 5 and R 6 each represents a member from the group consisting of hydrogen and lower alkyl and n represents 1 or 2.
Claim 3
Dependent Claim 54 words
A compound as claimed in claim 1 of which is a fluorene derivative of formula ##SPC10##or a pharmaceutically acceptable acid addition salt thereof wherein R 1 is selected from the group consisting of hydrogen, hydroxyl, lower alkyl, lower alkoxy and halogen and R 3 is selected from the group consisting of hydrogen and halogen.
Claim 4
Dependent Claim 9 words
A compound as claimed in claim 1 which 9-(1,4,5,6-tetrahydro-2-pyrimidinyl)-9H-fluoren-9-ol.

References Cited (Backward Citations)

US2948424A Cited
US3833655A Cited
US3888846A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-07-27 1980-01-26 1980-07-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-07-27 1984-01-26 1984-07-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-07-27 1988-01-26 1988-07-27 $7700.00 Window Closed / Lapsed

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