Patent US3973006A successfully refreshed from Google Patents.
US3973006A
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Peptide enzyme inhibitors of angiotensin I
Assignee: ER Squibb and Sons LLC
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Filing: 1975-02-21
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Granted: 1976-08-03
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Expires: 1995-02-21
Abstract
Abstract Ester and amides of the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro have been found to inhibit the hypertensive effect of angiotensin I.
Inventors
- 👤 Miguel Angel Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:09
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
19 words
A peptide having the formula Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OR or Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-NH.sub.2 wherein R is an alkyl group containing 1 to 10 carbons.
Claim 2
Dependent Claim
19 words
A peptide having the formula Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OR or Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-NH.sub.2 wherein R is an alkyl group containing 1 to 10 carbons.
Claim 3
Dependent Claim
18 words
The peptide as defined in claim 1 wherein R is an alkyl group containing 1 to 6 carbons.
Claim 4
Dependent Claim
11 words
The peptide as defined in claim 2 wherein R is methyl.
Claim 5
Dependent Claim
11 words
The peptide as defined in claim 2 wherein R is t-butyl.
Claim 6
Dependent Claim
22 words
A method for treating hypertension in mammalian species, which comprises administering a therapeutic amount of a peptide as defined in claim 1.
Claim 7
Dependent Claim
93 words
A method for forming the peptide as defined in claim 1 and having the formula Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OR, (1) which comprises deprotecting a peptide of the formula ##EQU1## wherein Z is benzyloxycarbonyl, and then reacting the deprotected peptide with a peptide of the formula Z-Trp-Pro-Tcp (3) wherein Z is as defined above and Tcp is 2,4,5-trichlorophenyl ester to form a peptide of the formula Z-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OR wherein Z is as defined above, and reacting the latter peptide (4) after deprotection with Pyr-OTcp (4) wherein Tcp is as defined above, to form the peptide of formula (1).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-03 | 1980-02-02 | 1980-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-03 | 1984-02-02 | 1984-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-03 | 1988-02-02 | 1988-08-03 | $7700.00 | Window Closed / Lapsed |