Patent US1408098A successfully refreshed from Google Patents.
US3984501A
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Phenyl- and benzylphosphonate esters
Assignee: Whitby Research Inc
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Filing: 1975-02-03
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Granted: 1976-10-05
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Expires: 1995-02-03
Abstract
Abstract Compounds having the structural formula ##SPC1## Wherein X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is H, alkyl, dialkylaminoethyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and R is H, lower alkyl, lower alkoxy, halogen, CF 3 , NO 2 , OH, CN, COOR 1 , ##EQU1## NHCOR 1 , NR 1 R 2 or ##EQU2## where R 1 and R 2 are each selected from the group consisting of H and lower alkyl; R, R 1 and R 2 being the same or different, T is 0 or 1 and n is 0-5; and pharmaceutically acceptable salts thereof.
Inventors
- 👤 Vithal J. Rajadhyaksha
- 👤 James V. Peck
- 👤 Julia J. Chouw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 20:50
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4056; A; A61; A61K; A61K31/00; A61K31/66; A61P; A61P43/00; C07F9/4071; C07F9/4084; D; D03; D03D; D03D49/00; D03D49/24; D03D49/26; D03D49/38
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
150 words
Phenyl- and benzylphosphonate esters having the structural formula ##SPC19## wherein X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is selected from the group consisting of H, an alkyl group having 1-12 carbon atoms, phenyl, benzyl and phenyl or benzyl substituted with one or more R; and R is selected from the group consisting of H, loweralkyl, lower alkoxy, halogen, CF 3 , NO 2 , OH, CN, COOR 1 , CONR 1 R 2 , NHCOR 1 , NR 1 R 2 , and CH 2 NR 1 R 2 R 1 and R 2 are each selected from the group consisting of H and lower alkyl, R, R 1 and R 2 being the same or different, T is 0 or 1, and n is 0-5; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
150 words
Phenyl- and benzylphosphonate esters having the structural formula ##SPC19## wherein X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is selected from the group consisting of H, an alkyl group having 1-12 carbon atoms, phenyl, benzyl and phenyl or benzyl substituted with one or more R; and R is selected from the group consisting of H, loweralkyl, lower alkoxy, halogen, CF 3 , NO 2 , OH, CN, COOR 1 , CONR 1 R 2 , NHCOR 1 , NR 1 R 2 , and CH 2 NR 1 R 2 R 1 and R 2 are each selected from the group consisting of H and lower alkyl, R, R 1 and R 2 being the same or different, T is 0 or 1, and n is 0-5; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
Compounds of claim 1 wherein X is an alkyl group having 3 carbon atoms.
Claim 4
Dependent Claim
14 words
Compounds of claim 2 wherein Y is selected from the groupsing consisting of ##SPC20##
Claim 5
Dependent Claim
24 words
Compounds of claim 3 wherein the phenolic oxygen which is part of the phosphonate group is attached to the benzene ring at the 4-position.
Claim 6
Dependent Claim
20 words
Compounds of claim 4 wherein R is selected from the group consisting of H and halogen and n is 1.
Claim 7
Dependent Claim
67 words
Benzyl phosphonate esters having the structural formula ##SPC21## wherein X is an alkyl or alkenyl chain having 3-5 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is selected from the group consisting of H, ##SPC22## R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen; n is 0-3 and pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
67 words
Benzyl phosphonate esters having the structural formula ##SPC21## wherein X is an alkyl or alkenyl chain having 3-5 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is selected from the group consisting of H, ##SPC22## R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen; n is 0-3 and pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
24 words
Benzylphosphonates having the structural formula ##SPC23## where R is selected from the group consisting of an H or halogen; and pharmaceutically acceptable salts thereof.
Claim 10
Dependent Claim
24 words
Benzylphosphonates having the structural formula ##SPC23## where R is selected from the group consisting of an H or halogen; and pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-05 | 1980-04-05 | 1980-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-05 | 1984-04-05 | 1984-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-05 | 1988-04-05 | 1988-10-05 | $7700.00 | Window Closed / Lapsed |