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US3985753A
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US
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7-Hydroxy-benzo[ij]quinolizine-2-carboxylic acids and derivatives thereof
Assignee: Riker Laboratories Inc
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Filing: 1975-04-14
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Granted: 1976-10-12
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Expires: 1995-04-14
Abstract
Abstract Certain substituted 6,7-dihydro-7-hydroxy-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids and salt and ester derivatives thereof are described. These compounds are useful antibacterial agents.
Inventors
- 👤 Dietrich Schuppan
- 👤 John F. Gerster
- 👤 Charles M. Leir
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:20
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; C07D215/233; C07D215/18; C07D215/48; C07D215/54; C07D215/56; C07D455/00; C07D455/03; C07D455/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
81 words
A compound of the formula ##SPC6## wherein R 1 is hydrogen, methyl or ethyl; R 2 is methyl, ethyl, halogen, hydroxy, nitro, amino, acetamido or formamido; n is zero, one or 2, and when n is 2, R 2 may be methylenedioxy or ethylenedioxy bonded to adjacent carbon atoms; and when R 2 is ethyl, methoxy, nitro, amino, acetamido or formamido, and n is 2, each R 2 must be different; and lower alkyl ester or pharmaceutically acceptable salt derivatives thereof.
Claim 2
Dependent Claim
81 words
A compound of the formula ##SPC6## wherein R 1 is hydrogen, methyl or ethyl; R 2 is methyl, ethyl, halogen, hydroxy, nitro, amino, acetamido or formamido; n is zero, one or 2, and when n is 2, R 2 may be methylenedioxy or ethylenedioxy bonded to adjacent carbon atoms; and when R 2 is ethyl, methoxy, nitro, amino, acetamido or formamido, and n is 2, each R 2 must be different; and lower alkyl ester or pharmaceutically acceptable salt derivatives thereof.
Claim 3
Dependent Claim
13 words
A compound according to claim 1 wherein R 1 is methyl or ethyl.
Claim 4
Dependent Claim
10 words
A compound according to claim 2 wherein n is one.
Claim 5
Dependent Claim
14 words
A compound according to claim 3 wherein R 2 is halogen, methyl or hydroxy.
Claim 6
Dependent Claim
14 words
A compound according to claim 4 wherein R 2 is fluorine, chlorine or bromine.
Claim 7
Dependent Claim
8 words
The compound 6,7-dihydro-9-fluoro-7-hydroxy-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid according to claim 5.
Claim 8
Dependent Claim
8 words
The compound 9-chloro-6,7-dihydro-7-hydroxy-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid according to claim 5.
Claim 9
Dependent Claim
22 words
A compound according to claim 1 wherein n is 2 and R 2 is ethylenedioxy or methylenedioxy bonded to adjacent carbon atoms.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |