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Polyhydrophenanthrene derivatives

Assignee: STWB Inc
•
Filing: 1975-04-07
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Granted: 1976-11-16
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Expires: 1995-04-07
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Abstract

Abstract Alkyl polyhydro-2-phenanthrylideneacetates are prepared by interacting the corresponding 2-oxopolyhydrophenanthrenes with a tri-lower-alkyl α-phosphono-lower-alkanoate. Said alkyl polyhydro-2-phenanthrylideneacetates are hydrolyzed to the free acid, and then reesterified via the acid chloride with a tertiaryamino-lower-alkanol to give basic esters having cardiotonic activity.

Inventors

  • 👤 Philip E. Shaw
  • 👤 Sol J. Daum
  • 👤 Robert L. Clarke

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 18:28
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/76; C07C59/90; C07C59/42; C07C59/46; C07C59/56; C07C59/58; C07C59/72; C07C59/80; C07C59/82; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/22; C07C2603/26

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 53 words
1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-7-oxophenanthrene bearing two lower-alkyl groups in the 8-position, a hydroxy or oxo group in the 2-position, and wherein the 10-position is unsubstituted or bears a hydroxy or acyloxy group wherein the acyl group is a carboxylic acyl group having from one to twelve carbon atoms and a molecular weight less than about 250.
Claim 2
Dependent Claim 53 words
1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-7-oxophenanthrene bearing two lower-alkyl groups in the 8-position, a hydroxy or oxo group in the 2-position, and wherein the 10-position is unsubstituted or bears a hydroxy or acyloxy group wherein the acyl group is a carboxylic acyl group having from one to twelve carbon atoms and a molecular weight less than about 250.
Claim 3
Dependent Claim 19 words
8,8-Di-lower-alkyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-7-oxo-2-phenanthrol, according to claim 1, wherein there is a hydroxy group in the 2-position and the 10-position is unsubstituted.
Claim 4
Dependent Claim 19 words
3,4,4a,4b,5,6,7,8,10,10a-Decahydro-8,8-di-lower-alkyl-7-oxo-2(1H)-phenanthrone, according to claim 1, wherein there is an oxo group in the 2-position and the 10-position is unsubstituted.
Claim 5
Dependent Claim 21 words
10-Acetoxy-8,8-di-lower-alkyl-3,4,4a,4b,5,6,7,8,10,10a-decahydro-7-oxo-2(1H)-phenanthrene, according to claim 1, wherein there is an oxo group in the 2-position and an acetoxy group in the 10-position.
Claim 6
Dependent Claim 21 words
10-Acetoxy-8,8-di-lower-alkyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-2-phenanthrol, according to claim 1, wherein there is a hydroxy group in the 2-position and an acetoxy group in the 10-position.

References Cited (Backward Citations)

US3553251A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-11-16 1980-05-17 1980-11-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-11-16 1984-05-17 1984-11-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-11-16 1988-05-17 1988-11-16 $7700.00 Window Closed / Lapsed

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