US3994935A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Steroidal 16β-alkyl[16α,17-b]naphthalenes
Assignee: ER Squibb and Sons LLC
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Filing: 1975-11-24
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Granted: 1976-11-30
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Expires: 1995-11-24
Abstract
Abstract Novel steroids having the structure ##SPC1## And the 1,2-dehydro derivatives thereof, wherein R 1 is chlorine, fluorine, or hydroxy and R' 1 is hydrogen or R 1 and R' 1 together are =O; R 2 is hydrogen or halogen; R 3 is hydrogen, methyl, or fluorine; R 4 is hydrogen, hydroxy, ##EQU1## or halogen; R 5 and R 6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##EQU2## hydroxy, halogen, phenyl or cyano, with the proviso that when R 5 and R 6 are different, one of R 5 and R 6 is hydrogen; and R 7 and R 8 are the same or different and are hydrogen or alkyl.
Inventors
- 👤 Ravi K. Varma
- 👤 Christopher M. Cimarusti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:11
CPC Classifications
C; C07; C07J; C07J71/00; C07J71/0036; C07J71/0042; C07J71/0052; A; A61; A61P; A61P29/00; C07J13/00; C07J13/005; C07J53/00; C07J53/002
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
114 words
A steroid having the formula ##SPC11## or the 1,2-dehydro derivatives thereof, wherein R 1 is chlorine, fluorine or hydroxy and R' 1 is hydrogen, or R 1 and R' 1 together are =O; R 2 is hydrogen or halogen; R 3 is hydrogen, methyl or fluorine; R 4 is hydrogen, hydroxy, ##EQU3## or halogen; R 5 and R 6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##EQU4## hydroxy, halogen, phenyl or cyano, with the proviso that when R 5 and R 6 are different, one of R 5 and R 6 is hydrogen; and R 7 and R 8 are the same or different and are hydrogen or alkyl.
Claim 2
Dependent Claim
114 words
A steroid having the formula ##SPC11## or the 1,2-dehydro derivatives thereof, wherein R 1 is chlorine, fluorine or hydroxy and R' 1 is hydrogen, or R 1 and R' 1 together are =O; R 2 is hydrogen or halogen; R 3 is hydrogen, methyl or fluorine; R 4 is hydrogen, hydroxy, ##EQU3## or halogen; R 5 and R 6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##EQU4## hydroxy, halogen, phenyl or cyano, with the proviso that when R 5 and R 6 are different, one of R 5 and R 6 is hydrogen; and R 7 and R 8 are the same or different and are hydrogen or alkyl.
Claim 3
Dependent Claim
15 words
A steroid in accordance with claim 1 wherein R 7 and R 8 are hydrogen.
Claim 4
Dependent Claim
17 words
A steroid in accordance with claim 1 wherein R 1 is hydroxy and R' 1 is hydrogen.
Claim 5
Dependent Claim
12 words
A steroid in accordance with claim 1 wherein R 3 is hydrogen.
Claim 6
Dependent Claim
12 words
A steroid in accordance with claim 1 wherein R 2 is fluorine.
Claim 7
Dependent Claim
15 words
The steroid in accordance with claim 1 having the name 9-fluoro-1' ,2' ,3' ,4'-tetrahydro-11β, 21-dihydroxy-16β-methylpregna-1,4-dieno[16α,17-b]naphthalene-3,20-dione.
Claim 8
Dependent Claim
13 words
The steroid in accordance with claim 1 having the name 21-(acetyloxy)-9-fluoro-1',2' ,3' ,4'-tetrahydro-11β-hydroxy16β-methylpregna-1,4-dieno[16α,17-b]naphthalene-3,20-dione.
Claim 9
Dependent Claim
87 words
A steroid having the formula ##SPC12## or the 1,2-dehydro derivative thereof, wherein R 3 is hydrogen, methyl, or fluorine; R 4 is hydrogen, hydroxy, ##STR4## or halogen; R 5 and R 6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##STR5## hydroxy, halogen, phenyl, or cyano, with the proviso that when R 5 and R 6 are different, one of R 5 and R 6 is hydrogen; and R 7 and R 8 are the same or different and are hydrogen or alkyl.
Claim 10
Dependent Claim
87 words
A steroid having the formula ##SPC12## or the 1,2-dehydro derivative thereof, wherein R 3 is hydrogen, methyl, or fluorine; R 4 is hydrogen, hydroxy, ##STR4## or halogen; R 5 and R 6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##STR5## hydroxy, halogen, phenyl, or cyano, with the proviso that when R 5 and R 6 are different, one of R 5 and R 6 is hydrogen; and R 7 and R 8 are the same or different and are hydrogen or alkyl.
References Cited (Backward Citations)
US3944584A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-30 | 1980-05-31 | 1980-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-30 | 1984-05-31 | 1984-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-30 | 1988-05-31 | 1988-11-30 | $7700.00 | Window Closed / Lapsed |