Abstract This invention is directed toward pharmacologically active compounds of the formula <IMAGE> wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C1-4alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula <IMAGE> in which Ra represents a hydrogen atom or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C-Rb wherein Rb represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R1 represents a hydrogen atom or a lower alkyl group; R2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R3 represents a phenyl, halophenyl or 2-pyridyl group AND ACID ADDITION SALTS THEREOF.
A compound of the formula ##STR24## wherein R is selected from the group consisting of a halogen atom, nitro and a trifluoromethyl group; R 1 is a hydrogen atom or a lower alkyl group; R 2 is an acyl group derived from a naturally occurring amino acid; R 3 is selected from the group consisting of phenyl and halophenyl; and R 4 is selected from the group consisting of a hydrogen atom, a methyl, cyclopropylmethyl, di(C 1-4 alkyl) aminoethyl, methoxymethyl and a hydroxyethyl group and the acid addition salts thereof.
Claim 2
Dependent Claim
90 words
A compound of the formula ##STR24## wherein R is selected from the group consisting of a halogen atom, nitro and a trifluoromethyl group; R 1 is a hydrogen atom or a lower alkyl group; R 2 is an acyl group derived from a naturally occurring amino acid; R 3 is selected from the group consisting of phenyl and halophenyl; and R 4 is selected from the group consisting of a hydrogen atom, a methyl, cyclopropylmethyl, di(C 1-4 alkyl) aminoethyl, methoxymethyl and a hydroxyethyl group and the acid addition salts thereof.
Claim 3
Dependent Claim
46 words
The compound of claim 1 wherein R is a chlorine, bromine or a nitro group; R 1 is a hydrogen atom; R 3 is a phenyl, o-fluorophenyl, o-chlorophenyl; and R 4 is a hydrogen atom, a methyl, diethylaminoethyl or methoxymethyl group, and acid addition salts thereof.