Patent US4018916A successfully refreshed from Google Patents.
US4018916A
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Antiviral ionic complexes of double-standard RNA
Assignee: Beecham Group PLC
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Filing: 1975-06-25
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Granted: 1977-04-19
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Expires: 1995-06-25
Abstract
Abstract Ionic complexes of double-stranded ribonucleic acids in which the cations are ammonium polymer polycations, demonstrate antiviral activity.
Inventors
- 👤 Richard Anthony Vere Hodge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:46
CPC Classifications
C; C07; C07H; C07H21/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
109 words
A pharmaceutical composition useful for treating susceptible DNA and RNA viral infections which comprises an antiviral amount of an antiviral substance which is a principally ionic complex in which the cations are organic polymer polycations which contains a repeat unit of formula (I): ##STR5## wherein m and n are the same or different and each is an integer from 3 to 5 and the anions are either (a) double-stranded ribonucleic acid polyanions, said double-stranded ribonucleic acid being of natural origin or (b) polyanions of a double-stranded N-oxide or alkali modified derivative of a double-stranded ribonucleic acid of natural origin, in combination with a pharmaceutically acceptable non-toxic diluent or carrier.
Claim 2
Dependent Claim
109 words
A pharmaceutical composition useful for treating susceptible DNA and RNA viral infections which comprises an antiviral amount of an antiviral substance which is a principally ionic complex in which the cations are organic polymer polycations which contains a repeat unit of formula (I): ##STR5## wherein m and n are the same or different and each is an integer from 3 to 5 and the anions are either (a) double-stranded ribonucleic acid polyanions, said double-stranded ribonucleic acid being of natural origin or (b) polyanions of a double-stranded N-oxide or alkali modified derivative of a double-stranded ribonucleic acid of natural origin, in combination with a pharmaceutically acceptable non-toxic diluent or carrier.
Claim 3
Dependent Claim
46 words
A pharmaceutical composition according to claim 1 wherein the organic polymer polycations have formula (II): ##STR6## wherein m and n are the same or different and each is an integer from 3 to 5 and X is an integer or fractional number from 4 to 3,000.
Claim 4
Dependent Claim
14 words
A pharmaceutical composition according to claim 2 wherein X is from 5 to 500.
Claim 5
Dependent Claim
35 words
A pharmaceutical composition according to claim 1 wherein the double-stranded ribonucleic acid component is derived from the virus particles found in infected strains of Penicillium chrysogenum, Penicillium stoloniforum, Penicillium cyaneofulvum, Aspergillus niger, or Aspergillus foetidus.
Claim 6
Dependent Claim
30 words
A pharmaceutical composition according to claim 1 wherein more than 60% of the anionic sites on the double-stranded ribonucleic acid anions are neutralized by the ammonium sites in the polycation.
Claim 7
Dependent Claim
30 words
A pharmaceutical composition according to claim 5 wherein more than 75% of the anionic sites on the double-stranded ribonucleic acid anions are neutralized by the ammonium sites in the polycation.
Claim 8
Dependent Claim
11 words
A pharmaceutical composition according to claim 1 in parenteral administration form.
Claim 9
Dependent Claim
11 words
A pharmaceutical composition according to claim 1 in topical application form.
References Cited (Backward Citations)
US3775398A
Cited
US3845033A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-18 | 1980-10-18 | 1981-04-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-18 | 1984-10-18 | 1985-04-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-18 | 1988-10-18 | 1989-04-19 | $7700.00 | Window Closed / Lapsed |