US4043989A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxazepam derivatives for immunoassay reagents
Assignee: Syva Co
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Filing: 1975-09-11
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Granted: 1977-08-23
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Expires: 1995-09-11
Abstract
Abstract Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine, which in turn are conjugated to antigenic polypeptides for formation of antibodies for use in immunoassays. The antibodies produced, when employed in immunoassays, are found to be able to detect the ingestion of a wide variety of benzdiazepine drugs as determined by positive results with the urine of the patient.
Inventors
- 👤 Richard S. Schneider
- 👤 Steven J. Gould
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:50
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; G01N33/948; C; C07; C07D; C07D243/00; C07D243/06; C07D243/10; C07D243/14; C07D243/16; C07D243/18; C07D243/24; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/807
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
75 words
A compound of the formula: ##STR6## wherein: A is hydrogen or lower alkyl of from 1 to 3 carbon atoms; R is a linking group of from 0 to 8 carbon atoms and 0 to 4 heteroatoms which are chalcogen and nitrogen; Z is Y, wherein Y is an antigenic poly(amino acid); n is at least 1 and not greater than the molecular weight of Y divided by 500; and X is chalcogen or nitrogen.
Claim 2
Dependent Claim
75 words
A compound of the formula: ##STR6## wherein: A is hydrogen or lower alkyl of from 1 to 3 carbon atoms; R is a linking group of from 0 to 8 carbon atoms and 0 to 4 heteroatoms which are chalcogen and nitrogen; Z is Y, wherein Y is an antigenic poly(amino acid); n is at least 1 and not greater than the molecular weight of Y divided by 500; and X is chalcogen or nitrogen.
Claim 3
Dependent Claim
20 words
A compound according to claim 1, wherein n is not greater than the molecular weight of Y divided by 1,500.
Claim 4
Dependent Claim
77 words
A compound of the formula: ##STR7## wherein: A is hydrogen or lower alkyl of from 1 to 3 carbon atoms; Z is an antigenic poly(amino acid); R 1 is an aliphatic radical of from 1 to 6 carbon atoms having from 0 to 1 site of ethylenic unsaturation and from 0 to 1 heteroatom of atomic number 7 to 8; n is at least 1 and not greater than the molecular weight of Z divided by 1,500.
Claim 5
Dependent Claim
77 words
A compound of the formula: ##STR7## wherein: A is hydrogen or lower alkyl of from 1 to 3 carbon atoms; Z is an antigenic poly(amino acid); R 1 is an aliphatic radical of from 1 to 6 carbon atoms having from 0 to 1 site of ethylenic unsaturation and from 0 to 1 heteroatom of atomic number 7 to 8; n is at least 1 and not greater than the molecular weight of Z divided by 1,500.
Claim 6
Dependent Claim
18 words
A compound according to claim 3, wherein R 1 is polymethylene of from 2 to 4 carbon atoms.
Claim 7
Dependent Claim
14 words
A compound according to claim 3, wherein said antigenic poly(amino acid) is an albumin.
Claim 8
Dependent Claim
31 words
A compound of the formula: ##STR8## wherein: Y is an antigenic poly(amino acid) and n is at least 1 and not greater than the molecular weight of Y divided by 1,500.
Claim 9
Dependent Claim
31 words
A compound of the formula: ##STR8## wherein: Y is an antigenic poly(amino acid) and n is at least 1 and not greater than the molecular weight of Y divided by 1,500.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-22 | 1981-02-21 | 1981-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-22 | 1985-02-21 | 1985-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-22 | 1989-02-21 | 1989-08-23 | $7700.00 | Window Closed / Lapsed |