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US4054488A
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Preservation of glucose in blood samples
Assignee: Individual
•
Filing: 1976-02-26
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Granted: 1977-10-18
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Expires: 1996-02-26
Abstract
Abstract A process and preservatives for preventing glycolysis in blood samples so as to preserve the glucose content and lactic acid content thereof. The preservatives do not produce any significant hemolysis in the blood sample, and they do not interfere with any of the known blood constituents. The preservatives comprise salts of Iodoacetic acid, such as Tris-Iodoacetate [(CH 2 OH) 3 NH 3 CO 2 -- CH 2 I]; salts of Bromoacetic acid, such as Tris-Bromoacetate [(CH 2 OH) 3 NH 3 CO 2 -- CH 2 Br], or Sodium Bromoacetate [NaO 2 CCH 2 Br]; and salts of mono Chloroacetic acid (ClCH 2 COOH), such as Sodium Chloroacetate (NaO 2 CCH 2 Cl).
Inventors
- 👤 Edward P. Marbach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 11:40
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/66; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104998; Y10T436/105831; Y10T436/106664; Y10T436/108331
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
39 words
A preserved sample including whole blood and a preservative to preserve the glucose content of said whole blood, said preservative being selected from a group consisting of Tris-Iodoacetate, a salt of Bromoacetic acid or a salt of Chloroacetic acid.
Claim 2
Dependent Claim
39 words
A preserved sample including whole blood and a preservative to preserve the glucose content of said whole blood, said preservative being selected from a group consisting of Tris-Iodoacetate, a salt of Bromoacetic acid or a salt of Chloroacetic acid.
Claim 3
Dependent Claim
25 words
The preserved sample defined in claim 1, in which the preservative is Tris-Iodoacetate in a concentration of substantially 3 milligrams per milliliter of whole blood.
Claim 4
Dependent Claim
24 words
The preserved sample defined in claim 1, in which said preservative is selected from a group consisting of Tris-Bromoacetate Sodium Bromoacetate or Sodium Chloroacetate.
Claim 5
Dependent Claim
32 words
The preserved sample defined in claim 3, in which the concentration of the preservative in the whole blood is substantially a range of 0.1-3 milligrams of preservative per milliliter of whole blood.
Claim 6
Dependent Claim
35 words
The preserved sample defined in claim 3, in which the preservative is selected from a group consisting of Sodium Bromoacetate or Sodium Chloroacetate in a concentration of substantially 1.5 milligrams per milliliter of whole blood.
Claim 7
Dependent Claim
38 words
A process for preventing glycolysis in a whole blood sample which comprises adding a preservative selected from a group consisting of Tris-Iodoacetate, a salt of Bromoacetic acid or a salt of Chloroacetic acid to the whole blood sample.
Claim 8
Dependent Claim
38 words
A process for preventing glycolysis in a whole blood sample which comprises adding a preservative selected from a group consisting of Tris-Iodoacetate, a salt of Bromoacetic acid or a salt of Chloroacetic acid to the whole blood sample.
Claim 9
Dependent Claim
24 words
The process defined in claim 6, in which the preservative is Tris-Iodoacetate in a concentration of substantially 3 milligrams per milliliter of whole blood.
Claim 10
Dependent Claim
32 words
A process for preventing glycolysis in a whole blood sample which comprises adding a preservative selected from a group consisting of Tris-Bromoacetate Sodium Chloroacetate or Sodium Bromoacetate to the whole blood sample.
Claim 11
Dependent Claim
32 words
A process for preventing glycolysis in a whole blood sample which comprises adding a preservative selected from a group consisting of Tris-Bromoacetate Sodium Chloroacetate or Sodium Bromoacetate to the whole blood sample.
Claim 12
Dependent Claim
33 words
The process defined in claim 8, in which the concentration of the preservative in the whole blood sample is substantially in the range of 0.1-3 milligrams of preservative per milliliter of whole blood.
Claim 13
Dependent Claim
25 words
The process defined in claim 8, in which the preservative is Sodium Chloroacetate in a concentration of substantially 1.5 milligrams per milliliter of whole blood.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-17 | 1981-04-18 | 1981-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-17 | 1985-04-18 | 1985-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-17 | 1989-04-18 | 1989-10-18 | $7700.00 | Window Closed / Lapsed |