US4057573A
Expired / Lapsed
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New hydroaromatic compounds
Assignee: Novartis Corp
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Filing: 1975-02-11
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Granted: 1977-11-08
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Expires: 1995-02-11
Abstract
Abstract Compounds of the general formula I ##STR1## wherein one of the two radicals R 1 and R 2 denotes the acyl radical of a carboxylic acid of aromatic character and the other denotes hydrogen or optionally esterified or etherified hydroxyl, R 3 denotes hydrogen, alkyl or hydroxyalkyl, R 4 denotes optionally esterified or amidised carboxyl, m denotes 1 or 2 and n denotes 0 or 1, in the free form or in the form of their salts are useful as antiphlogistics, mild analgesics, antipyretics and as anti-rheumatic agents.
Inventors
- 👤 Georges Haas
- 👤 Alberto Rossi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 15:32
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/42; C07C59/54; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
107 words
A compound of the general formula ##STR7## wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by at least one member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid, or hydroxy etherified by a lower alkanol, R 3 denotes hydrogen, lower alkyl or lower hydroxyalkyl, R 4 denotes carboxyl, or carboxyl esterified by a lower alkanol or a lower alkanol which is substituted by hydroxy or lower alkoxy, m denotes 1 or 2 and n denotes 0 or 1, therapeutically acceptable salts of said carboxyl compounds.
Claim 2
Dependent Claim
107 words
A compound of the general formula ##STR7## wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by at least one member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid, or hydroxy etherified by a lower alkanol, R 3 denotes hydrogen, lower alkyl or lower hydroxyalkyl, R 4 denotes carboxyl, or carboxyl esterified by a lower alkanol or a lower alkanol which is substituted by hydroxy or lower alkoxy, m denotes 1 or 2 and n denotes 0 or 1, therapeutically acceptable salts of said carboxyl compounds.
Claim 3
Dependent Claim
118 words
A compound as claimed in claim 1, of the general formula I, wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid, or hydroxy etherified by a lower alkanol, in each case with up to 7 carbon atoms, R 3 denotes hydrogen, lower alkyl or α-hydroxy-lower alkyl each with up to 4 carbon atoms, R 4 denotes carboxyl, or carboxyl esterified by a lower alkanol, or a lower alkanol substituted by lower alkoxy or by hydroxy, n is 0 or 1 and m denotes 1 or 2.
Claim 4
Dependent Claim
117 words
A compound as claimed in claim 1, of the general formula I, wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, or hydroxy esterified by a lower alkanecarboxylic acid with 2 to 4 carbon atoms, or hydroxy esterified by a lower alkanol with 1 to 4 carbon atoms, R 3 denotes hydrogen or lower alkyl with up to 4 carbon atoms, R 4 denotes carboxyl, or carboxyl esterified by a lower alkanol, or a lower alkanol substituted by lower alkoxy or by hydroxy, n is 0 or 1 and m is 1.
Claim 5
Dependent Claim
55 words
A compound as claimed in claim 1, of the general formula I, wherein one of the radicals R 1 and R 2 denotes benzoyl and the other denotes hydroxyl, R 3 denotes hydrogen, R 4 denotes carboxyl, or carboxyl esterified by a lower alkanol with 1-4 carbon atoms, n is 0 and m is 1.
Claim 6
Dependent Claim
73 words
A compound as claimed in claim 1 of the general formula I, wherein one of the radicals R 1 and R 2 denotes benzoyl, or benzoyl mono-substituted by lower alkyl or lower alkoxy with up to 4 carbon atoms, trifluoromethyl or halogen and the other denotes hydroxy, R 3 denotes hydrogen, R 4 denotes carboxyl, or carboxyl esterified by a lower alkanol with 1-4 carbon atoms, n is 0 and m is 1.
Claim 7
Dependent Claim
12 words
A compound as claimed in claim 1 being 5-benzoyl-6-hydroxyindane-1-carboxylic acid methyl ester.
Claim 8
Dependent Claim
16 words
A compound as claimed in claim 1 being 5-benzoyl-6-hydroxy-indane-1-carboxylic acid or a therapeutically acceptable salt thereof.
Claim 9
Dependent Claim
12 words
A compound as claimed in claim 1 being 5-benzoyl-6-hydroxyindane-1-carboxylic acid n-butyl ester.
Claim 10
Dependent Claim
12 words
A compound as claimed in claim 1 being 5-benzoyl-6-hydroxyindane-1-carboxylic acid ethyl ester.
Claim 11
Dependent Claim
16 words
A compound as claimed in claim 1 being 5-(p-chlorobenzoyl)-6-hydroxy-indane-1-carboxylic acid or a therapeutically acceptable salt thereof.
Claim 12
Dependent Claim
16 words
A compound as claimed in claim 1 being 5-(o-chlorobenzoyl)6-hydroxy-indane-1-carboxylic acid or a therapeutically acceptable salt thereof.
References Cited (Backward Citations)
US3940434A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |