Patent US4075194A successfully refreshed from Google Patents.
US4075194A
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Novel synthetic undecapeptide and clinical assay
Assignee: Yeda Research and Development Co Ltd
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Filing: 1976-12-09
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Granted: 1978-02-21
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Expires: 1996-12-09
Abstract
Abstract A novel synthetic peptide corresponding to the eleven amino acid residues of the NH 2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL)-alanine as well as to bovine serum albumin. The resulting macromolecular conjugates provoked rabbit anti- CEA(1-11) peptide antibodies and a novel assay was developed for ascertaining the presence of adenocarcinomas of the digestive tract, pancreas and breast, based on said novel compositions of matter.
Inventors
- 👤 Michael Sela
- 👤 Ruth Arnon
- 👤 Samario Chaitchik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:37
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/705; C07K1/00; C07K1/006; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/575; G01N33/57565; Y; Y10; Y10S; Y10S436/00; Y10S436/802; Y10S436/804; Y10S436/811; Y10S436/813; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
22 words
The synthetic undecapeptide corresponding to the terminal amino acid residues of the amino-terminal portion of carcinoembrionic antigen (CEA) of the sequence Leu-Asn-Phe-Pro-Thr-Ser-Glu-Ile-Thr-Leu-Lys.
Claim 2
Dependent Claim
22 words
The synthetic undecapeptide corresponding to the terminal amino acid residues of the amino-terminal portion of carcinoembrionic antigen (CEA) of the sequence Leu-Asn-Phe-Pro-Thr-Ser-Glu-Ile-Thr-Leu-Lys.
Claim 3
Dependent Claim
29 words
A synthetic undecapeptide according to claim 1, bonded via a water-soluble diimide to a macromolecular carrier selected from the group consisting of multichain poly-DL-alanine, bovine serum albumin or ribonulcease.
Claim 4
Dependent Claim
14 words
A conjugate according to claim 2, wherein the coupling agent is ECDI (1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-20 | 1981-08-22 | 1982-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-20 | 1985-08-22 | 1986-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-20 | 1989-08-22 | 1990-02-21 | $7700.00 | Window Closed / Lapsed |