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US4085202A
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US
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Testosterone derivatives
Assignee: Becton Dickinson and Co
•
Filing: 1976-09-29
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Granted: 1978-04-18
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Expires: 1996-09-29
Abstract
Abstract Testosterone-15α or β-carboxyethyl thioether, 5α-, dihydrotestosterone-15α or β-carboxyethyl thioether related compounds and intermediates for preparation thereof. The compounds are conjugated to an immunological protein and employed to elicit an antibody highly specific to testosterone and 5α-dihydrotestosterone respectively. The elicited antibody can be employed for determination of testosterone and 5α-dihydrotestosterone respectively, in samples, by radioimmunoassay.
Inventors
- 👤 Pemmaraju Narasimha Rao
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 22:44
CPC Classifications
C; C07; C07J; C07J31/00; C07J31/003; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/743; Y; Y10; Y10S; Y10S436/00; Y10S436/815; Y10S436/817; Y10S436/822; Y10S436/823
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
86 words
An immunogen comprising: an immunological carrier having conjugated thereto by a chemical coupling agent a compound selected from the group consisting of compounds represented by the formula: ##STR4## wherein R is an alkyl group of from 1 to 6 carbon atoms A is selected from the group consisting of --OH, --OM wherein M is an alkali metal barium, calcium, or strontium, and OY wherein Y is an alkyl group of from 1 to 6 carbon atoms; and ##STR5## wherein R and A are as defined above.
Claim 2
Dependent Claim
86 words
An immunogen comprising: an immunological carrier having conjugated thereto by a chemical coupling agent a compound selected from the group consisting of compounds represented by the formula: ##STR4## wherein R is an alkyl group of from 1 to 6 carbon atoms A is selected from the group consisting of --OH, --OM wherein M is an alkali metal barium, calcium, or strontium, and OY wherein Y is an alkyl group of from 1 to 6 carbon atoms; and ##STR5## wherein R and A are as defined above.
Claim 3
Dependent Claim
12 words
The immunogen of claim 1 wherein the compound has structural formula (a).
Claim 4
Dependent Claim
13 words
The immunogen of claim 2 wherein the compound is in the 15β form.
Claim 5
Dependent Claim
9 words
The immunogen of claim 3 wherein A is --OH.
Claim 6
Dependent Claim
15 words
The immunogen of claim 4 wherein R is an alkyl group having 2 carbon atoms.
Claim 7
Dependent Claim
12 words
The immunogen of claim 1 wherein the compound has structural formula (b).
Claim 8
Dependent Claim
13 words
The immunogen of claim 6 wherein the compound is in the 15β form.
Claim 9
Dependent Claim
9 words
The immunogen of claim 7 wherein A is --OH.
Claim 10
Dependent Claim
15 words
The immunogen of claim 8 wherein R is an alkyl group having 2 carbon atoms.
Claim 11
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 2 into a host animal.
Claim 12
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 3 into a host animal.
Claim 13
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 4 into a host animal.
Claim 14
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 5 into a host animal.
Claim 15
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 6 into a host animal.
Claim 16
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 7 into a host animal.
Claim 17
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 8 into a host animal.
Claim 18
Dependent Claim
14 words
The antibody produced by injecting the immunogen of claim 9 into a host animal.
Claim 19
Dependent Claim
32 words
In the radioimmunoassay of testosterone in a sample employing radiolabeled testosterone and an antibody for binding testosterone and radiolabeled testosterone, the improvement comprising: employing the antibody of claim 13 as said antibody.
Claim 20
Dependent Claim
32 words
In the radioimmunoassay of 5-α-dihydrotestosterone in a sample employing radiolabeled 5-α-dihydrotestosterone and an antibody for binding 5-α-dihydrotestosterone and radiolabeled 5-α-dihydrotestosterone the improvement comprising: employing the antibody of claim 17 as said antibody.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-17 | 1981-10-17 | 1982-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-17 | 1985-10-17 | 1986-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-17 | 1989-10-17 | 1990-04-18 | $7700.00 | Window Closed / Lapsed |