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US4101422A
Expired / Lapsed
US
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Copolyesters useful in blood separation assemblies
Assignee: Henkel Corp
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Filing: 1977-05-11
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Granted: 1978-07-18
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Expires: 1997-05-11
Abstract
Abstract Copolyesters are provided which are derived from mixed dibasic acids and a branched-chain diol. These copolyesters possess a unique balance of physical and chemical characteristics which permits their use in small amounts in blood separation tubes to provide an effective barrier between the light and heavy phases of the blood after centrifuging.
Inventors
- 👤 James Lamont
- 👤 Robert J. Braun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:48
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5021; C; C08; C08G; C08G63/00; C08G63/02; C08G63/12; C08G63/16; C08G63/20; C08G63/46; C08G63/48; C08K; C08K3/00; C08K3/01; C08K3/013; C08K3/34; C08K3/36; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
169 words
A method of separating the serum and clot portions of a blood sample which comprises centrifuging the blood in a blood separation assembly with a small but effective amount of an inert, homogeneous, hydrophobic copolyester having a 210° F viscosity of 2,000 to 8,000 centistokes, density in the range 1.015 to 1.060 g/cm 3 and obtained by the reaction of essentially stoichiometric amounts of (a) a saturated aliphatic dicarboxylic acid having 4 to 12 carbon atoms, (b) a polymeric fatty acid containing 75% by weight or more C 36 dibasic acid, and (c) a branched-chain aliphatic dihydric alcohol having 3 to 8 carbon atoms, a mixture of said branched-chain dihydric alcohols, or a mixture containing at least 50% by weight said branched-chain aliphatic dihydric alcohols and a straight-chain aliphatic dihydric alcohol having 2 to 8 carbon atoms, the equivalents ratio of (a) to (b) ranging from 0.80:0.20 to 0.97:0.03, until the copolyester locates at the interface between the serum and clot portions and forms a continuous integral barrier therebetween.
Claim 2
Independent Claim
169 words
A method of separating the serum and clot portions of a blood sample which comprises centrifuging the blood in a blood separation assembly with a small but effective amount of an inert, homogeneous, hydrophobic copolyester having a 210° F viscosity of 2,000 to 8,000 centistokes, density in the range 1.015 to 1.060 g/cm 3 and obtained by the reaction of essentially stoichiometric amounts of (a) a saturated aliphatic dicarboxylic acid having 4 to 12 carbon atoms, (b) a polymeric fatty acid containing 75% by weight or more C 36 dibasic acid, and (c) a branched-chain aliphatic dihydric alcohol having 3 to 8 carbon atoms, a mixture of said branched-chain dihydric alcohols, or a mixture containing at least 50% by weight said branched-chain aliphatic dihydric alcohols and a straight-chain aliphatic dihydric alcohol having 2 to 8 carbon atoms, the equivalents ratio of (a) to (b) ranging from 0.80:0.20 to 0.97:0.03, until the copolyester locates at the interface between the serum and clot portions and forms a continuous integral barrier therebetween.
Claim 3
Dependent Claim
40 words
The method of claim 1 wherein the copolyester has a density of 1.020 and 1.050 g/cm 3 and contains up to about 35 weight percent of an inert filler selected from the group consisting of alumina, silica, talc and bentonite.
Claim 4
Dependent Claim
52 words
The method of claim 2 wherein the copolyester is derived from a saturated aliphatic dicarboxylic acid having from 6 to 12 carbon atoms, a polymeric fatty acid containing 85% or more C 36 dibasic acid and a mixture of neopentyl glycol and 1,2-propanediol present in an equivalents ratio of 0.85:0.15 to 0.99:0.01.
Claim 5
Dependent Claim
15 words
The method of claim 3 wherein the copolyester contains 5 to 25 weight percent silica.
References Cited (Backward Citations)
US3852194A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |