US4101664A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)-imidazoles
Assignee: Janssen Pharmaceutica NV
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Filing: 1976-10-15
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Granted: 1978-07-18
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Expires: 1996-10-15
Abstract
Abstract 1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)-imidazoles useful as antifungal and antibacterial agents.
Inventors
- 👤 Jan Heeres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:42
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/04; C07D303/08; C07D303/12; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/16; C07D317/18; C07D317/22
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
93 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula: ##STR7## and the therapeutically acceptable acid addition salts thereof, wherein: Ar 1 is a member selected from the group consisting of naphthalenyl, thienyl, halothienyl, nitrophenyl, cyanophenyl, lower alkyl-halophenyl and lower alkyloxy-halophenyl; and Ar 2 is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl and halonaphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, cyano, phenyl and phenylmethyl.
Claim 2
Dependent Claim
93 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula: ##STR7## and the therapeutically acceptable acid addition salts thereof, wherein: Ar 1 is a member selected from the group consisting of naphthalenyl, thienyl, halothienyl, nitrophenyl, cyanophenyl, lower alkyl-halophenyl and lower alkyloxy-halophenyl; and Ar 2 is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl and halonaphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, cyano, phenyl and phenylmethyl.
Claim 3
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1[4-(4-bromophenoxymethyl)-2-(4-chloro-2-methylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
18 words
A chemical compound selected from the group consisting of 1[4-(4-bromophenoxymethyl)-2-(4-chloro-2-methylphenyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
18 words
A chemical compound selected from the group consisting of cis-1-[2-(4-bromo-2-methylphenyl)-4-(4-bromophenoxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
18 words
A chemical compound selected from the group consisting of cis-1-[2-(4-bromo-2-methylphenyl)-4-(4-bromophenoxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazole and the therapeutically acceptable acid addition salts thereof.
Claim 7
Dependent Claim
132 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective antifungal or antibacterial amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##STR8## and the therapeutically active acid addition salts and stereochemical optical isomeric forms thereof, wherein: Ar 1 is a member selected from the group consisting of naphthalenyl, thienyl, halothienyl, nitrophenyl, cyanophenyl, lower alkylhalophenyl and lower alkyloxy-halophenyl; and Ar 2 is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl and halonaphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, cyano, phenyl and phenylmethyl.
Claim 8
Dependent Claim
132 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective antifungal or antibacterial amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##STR8## and the therapeutically active acid addition salts and stereochemical optical isomeric forms thereof, wherein: Ar 1 is a member selected from the group consisting of naphthalenyl, thienyl, halothienyl, nitrophenyl, cyanophenyl, lower alkylhalophenyl and lower alkyloxy-halophenyl; and Ar 2 is a member selected from the group consisting of phenyl, substituted phenyl, naphthalenyl and halonaphthalenyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, cyano, phenyl and phenylmethyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |