US4101665A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)imidazoles
Assignee: Janssen Pharmaceutica NV
•
Filing: 1976-10-15
•
Granted: 1978-07-18
•
Expires: 1996-10-15
Abstract
Abstract 1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)imidazoles, useful as antifungal and antibacterial agents.
Inventors
- 👤 Jan Heeres
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 03:33
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/04; C07D303/08; C07D303/12; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/16; C07D317/18; C07D317/22
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
111 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula: ##STR10## and the therapeutically acceptable acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano; R is a member selected from the group consisting of nitro, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl and trifluoromethyl; and R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and lower alkyloxy.
Claim 2
Dependent Claim
111 words
A chemical compound selected from the group consisting of an imidazole derivative having the formula: ##STR10## and the therapeutically acceptable acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano; R is a member selected from the group consisting of nitro, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl and trifluoromethyl; and R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and lower alkyloxy.
Claim 3
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl-1,3-dioxolan-4-ylmethoxy]phenyl}phenylmethanone nitrate and the therapeutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl-1,3-dioxolan-4-ylmethoxy]phenyl}phenylmethanone nitrate and the therapeutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-1-{2-(2,4-dichlorophenyl)-4-[3-(trifluoromethyl)phenoxymethyl]-1,3-dioxolan-2-ylmethyl}-1H-imidazole nitrate, and the therapeutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-1-{2-(2,4-dichlorophenyl)-4-[3-(trifluoromethyl)phenoxymethyl]-1,3-dioxolan-2-ylmethyl}-1H-imidazole nitrate, and the therapeutically acceptable acid addition salts thereof.
Claim 7
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}ethanone nitrate, and the therapeutically acceptable acid addition salts thereof.
Claim 8
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}ethanone nitrate, and the therapeutically acceptable acid addition salts thereof.
Claim 9
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-1-propanone nitrate and the therapeutically acceptable acid addition salts thereof.
Claim 10
Dependent Claim
19 words
A chemical compound selected from the group consisting of cis-1-{4-[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-1-propanone nitrate and the therapeutically acceptable acid addition salts thereof.
Claim 11
Dependent Claim
149 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective antifungal or antibacterial amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##STR11## and the therapeutically active acid addition salts and stereochemical optical isomers thereof, wherein; Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano; R is a member selected from the group consisting of nitro, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl and trifluoromethyl; and R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and lower alkyloxy.
Claim 12
Dependent Claim
149 words
A composition for combatting the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an effective antifungal or antibacterial amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##STR11## and the therapeutically active acid addition salts and stereochemical optical isomers thereof, wherein; Ar is a member selected from the group consisting of phenyl, substituted phenyl, thienyl, halothienyl and naphthyl, and wherein said substituted phenyl is phenyl having from 1 to 3 substituents independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, nitro and cyano; R is a member selected from the group consisting of nitro, benzoyl, halobenzoyl, lower alkylcarbonyl, lower alkyloxycarbonyl and trifluoromethyl; and R 1 and R 2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and lower alkyloxy.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |