Patent US4144329A successfully refreshed from Google Patents.
US4144329A
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US
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Antitumor antibiotics MA 144-M1 and MA 144-M2
Assignee: Microbial Chemistry Research Foundation
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Filing: 1977-03-24
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Granted: 1979-03-13
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Expires: 1997-03-24
Abstract
Abstract New antitumor agents designated MA 144-M1 and MA 144-M2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
Inventors
- 👤 Hamao Umezawa
- 👤 Tomio Takeuchi
- 👤 Hiroshi Naganawa
- 👤 all of Ishizuka Masaaki
- 👤 Norio Shibamoto
- 👤 Toshikazu Oki
- 👤 Taiji Inui
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 03:13
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P31/00; A61P31/04; A61P35/00; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/56; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/48; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/888
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
48 words
An anthracycline glycoside selected from the group consisting of a compound of the general formula ##STR4## wherein R represents a hydrogen atom or a hydroxyl group, a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said glycoside being substantially free of substances co-produced therewith.
Claim 2
Dependent Claim
48 words
An anthracycline glycoside selected from the group consisting of a compound of the general formula ##STR4## wherein R represents a hydrogen atom or a hydroxyl group, a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said glycoside being substantially free of substances co-produced therewith.
Claim 3
Dependent Claim
27 words
An anthracycline glycoside of the general formula ##STR5## wherein R represents a hydrogen atom or a hydroxyl group, said glycoside being substantially free of substances coproduced therewith.
Claim 4
Dependent Claim
27 words
An anthracycline glycoside of the general formula ##STR5## wherein R represents a hydrogen atom or a hydroxyl group, said glycoside being substantially free of substances coproduced therewith.
Claim 5
Dependent Claim
41 words
A compound selected from the group consisting of the anthracycline glycoside, MA 144-M 1 , of the formula ##STR6## a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said compound being substantially free of substancs co-produced therewith.
Claim 6
Dependent Claim
41 words
A compound selected from the group consisting of the anthracycline glycoside, MA 144-M 1 , of the formula ##STR6## a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said compound being substantially free of substancs co-produced therewith.
Claim 7
Dependent Claim
20 words
The anthracycline glycoside, MA 144-M 1 , of the formula ##STR7## said glycoside being substantially free of substances co-produced therewith.
Claim 8
Dependent Claim
20 words
The anthracycline glycoside, MA 144-M 1 , of the formula ##STR7## said glycoside being substantially free of substances co-produced therewith.
Claim 9
Dependent Claim
41 words
A compound selected from the group consisting of the anthracycline glycoside, MA 144-M 2 , of the formula ##STR8## a nontoxic acid addition salt thereof and a complex therewith with deoxyribonucleic acid, said compound being substantially free of substances co-produced therewith.
Claim 10
Dependent Claim
41 words
A compound selected from the group consisting of the anthracycline glycoside, MA 144-M 2 , of the formula ##STR8## a nontoxic acid addition salt thereof and a complex therewith with deoxyribonucleic acid, said compound being substantially free of substances co-produced therewith.
Claim 11
Dependent Claim
19 words
The anthracycline glycoside, MA 144-M 2 of the formula ##STR9## said glycoside being substantially free of substances co-produced therewith.
Claim 12
Dependent Claim
19 words
The anthracycline glycoside, MA 144-M 2 of the formula ##STR9## said glycoside being substantially free of substances co-produced therewith.
Claim 13
Dependent Claim
81 words
A pharmaceutical composition in a form suitable for parenteral administration to mammals comprising an effective antibacterial amount of an anthracycline glycoside selected from the group consisting of a compound of the general formula ##STR10## wherein R represents a hydrogen atom or a hydroxyl group, a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said glycoside being substantially free of substances co-produced therewith, in combination with an inert pharmaceutically acceptable carrier or diluent suitable for said administration form.
Claim 14
Dependent Claim
81 words
A pharmaceutical composition in a form suitable for parenteral administration to mammals comprising an effective antibacterial amount of an anthracycline glycoside selected from the group consisting of a compound of the general formula ##STR10## wherein R represents a hydrogen atom or a hydroxyl group, a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said glycoside being substantially free of substances co-produced therewith, in combination with an inert pharmaceutically acceptable carrier or diluent suitable for said administration form.
Claim 15
Dependent Claim
37 words
The pharmaceutical composition according to claim 7 wherein the anthracycline glycoside is a member selected from the group consisting of MA 144-M 1 , a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid.
Claim 16
Dependent Claim
37 words
The pharmaceutical composition according to claim 7 wherein the anthracycline glycoside is a member selected from the group consisting of MA 144-M 2 , a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid.
Claim 17
Dependent Claim
97 words
A pharmaceutical composition in a form suitable for parenteral administration to animals comprising an effective tumor inhibiting amount of an anthracycline glycoside selected from the group consisting of a compound of the general formula ##STR11## wherein R represents a hydrogen atom or a hydroxyl group, a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said glycoside being substantially free of substances co-produced therewith, in combination with an inert pharmaceutically acceptable carrier or diluent suitable for said administration form, said tumor being selected from the group consisting of Leukemia L1210, P388 and Sarcoma 180.
Claim 18
Dependent Claim
97 words
A pharmaceutical composition in a form suitable for parenteral administration to animals comprising an effective tumor inhibiting amount of an anthracycline glycoside selected from the group consisting of a compound of the general formula ##STR11## wherein R represents a hydrogen atom or a hydroxyl group, a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid, said glycoside being substantially free of substances co-produced therewith, in combination with an inert pharmaceutically acceptable carrier or diluent suitable for said administration form, said tumor being selected from the group consisting of Leukemia L1210, P388 and Sarcoma 180.
Claim 19
Dependent Claim
37 words
The pharmaceutical composition according to claim 10 wherein the anthracycline glycoside is a member selected from the group consisting of MA 144-M 1 , a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid.
Claim 20
Dependent Claim
37 words
The pharmaceutical composition according to claim 10 wherein the anthracycline glycoside is a member selected from the group consisting of MA 144-M 2 , a nontoxic acid addition salt thereof and a complex thereof with deoxyribonucleic acid.
References Cited (Backward Citations)
US3988315A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-12 | 1982-09-11 | 1983-03-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-12 | 1986-09-11 | 1987-03-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-12 | 1990-09-11 | 1991-03-13 | $7700.00 | Window Closed / Lapsed |