Patent US4153788A successfully refreshed from Google Patents.
US4153788A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process of preparing mono-O-β-hydroxyethyl-7 rutoside
Assignee: Haleon CH SARL
•
Filing: 1977-03-07
•
Granted: 1979-05-08
•
Expires: 1997-03-07
Abstract
Abstract A process is provided for preparing mono-O-β-hydroxyethyl-7-rutoside of the formula: ##STR1## which comprises contacting rutoside of the formula: ##STR2## in a solvent which is an at least partially aqueous medium with a boric acid alkali salt in an amount substantially not exceeding the amount necessary to form a boron complex of formula: reacting said boron complex with ethylene oxide to form a hydroxyethoxy compound of the formula ##STR3## and treating said hydroxyethoxy compound in an at least partially aqueous acid medium, whereby there is produced said mono-O-β-hydroxyethyl-7-rutoside.
Inventors
- 👤 Pierre Courbat
- 👤 Alban Albert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:18
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/06; C07H17/065; C07H17/07
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
87 words
A process for preparing mono-0-β-hydroxyethyl rutoside of the formula: ##STR8## which comprises contacting rutoside of the formula: ##STR9## in a solvent which is an at least partially aqueous medium with a boric acid alkali salt in an amount substantially not exceeding the amount necessary to form a boron complex of formula: ##STR10## reacting said boron complex with ethylene oxide to form a hydroxyethoxy compound of the formula ##STR11## and treating said hydroxyethoxy compound in an at least partially aqueous acid medium, whereby there is produced said mono-0-β-hydroxyethyl-7-rutoside.
Claim 2
Dependent Claim
87 words
A process for preparing mono-0-β-hydroxyethyl rutoside of the formula: ##STR8## which comprises contacting rutoside of the formula: ##STR9## in a solvent which is an at least partially aqueous medium with a boric acid alkali salt in an amount substantially not exceeding the amount necessary to form a boron complex of formula: ##STR10## reacting said boron complex with ethylene oxide to form a hydroxyethoxy compound of the formula ##STR11## and treating said hydroxyethoxy compound in an at least partially aqueous acid medium, whereby there is produced said mono-0-β-hydroxyethyl-7-rutoside.
Claim 3
Dependent Claim
11 words
A process of claim 1 wherein said alkali metal is sodium.
Claim 4
Dependent Claim
10 words
The process of claim 2, wherein the solvent is water.
Claim 5
Dependent Claim
18 words
The process of claim 2, wherein the solvent is a mixture of water and a lower aliphatic alcohol.
Claim 6
Dependent Claim
34 words
The process of claim 2, wherein said boric acid salt is borax of formula Na 2 B 4 O 7 .10.H 2 O used in an amount substantially equimolar to the amount of rutoside.
Claim 7
Dependent Claim
23 words
The process of claim 2, wherein the reaction with ethylene oxide is carried out in the presence of sodium acetate as a catalyst.
Claim 8
Dependent Claim
21 words
The process of claim 2, wherein the reaction with ethylene oxide is made at a temperature between 30° and 50° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-07 | 1982-11-06 | 1983-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-07 | 1986-11-06 | 1987-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-07 | 1990-11-06 | 1991-05-08 | $7700.00 | Window Closed / Lapsed |