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US4175544A Expired / Lapsed US ⏱️ 0.0 years remaining

Iodo-aryl carbonates for use in methods in radiography

Assignee: Lafayette Pharmacal Inc
•
Filing: 1978-06-28
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Granted: 1979-11-27
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Expires: 1998-06-28
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Abstract

Abstract A method for using iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, to provide radiopaques for various radiography purposes in connection with such techniques as X-ray applications including myelography, salpingography, lymphography and bronchography. The method first comprises selecting a compound generally categorized as a carbonate and having the general formula ##STR1## wherein R represents an alkyl group having from 1 to 10 carbon atoms and R' represents an iodinated phenyl linked directly to the ester oxygen or through an alkyl chain consisting of 1 to 3 carbon atoms. An effective amount of a pharmaceutically acceptable carbonate, as defined herein, is then placed into the subject body cavity and the particular X-ray or other study performed of this area.

Inventors

  • 👤 Barry N. Newton

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-29 03:05
CPC Classifications
A; A61; A61K; A61K51/00; C; C07; C07C; C07C68/00; C07C68/02

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 38 words
A method for visualizing an inner body cavity in an animal comprising: (a) placing an effective amount of a pharmaceutically acceptable iodinated phenyl carbonate compound into a body cavity in an animal; and (b) X-raying the body cavity.
Claim 2
Independent Claim 38 words
A method for visualizing an inner body cavity in an animal comprising: (a) placing an effective amount of a pharmaceutically acceptable iodinated phenyl carbonate compound into a body cavity in an animal; and (b) X-raying the body cavity.
Claim 3
Dependent Claim 73 words
The method of claim 1 wherein the pharmaceutically acceptable iodinated phenyl carbonate compound is of the formula ##STR26## wherein: (a) R is a lower alkyl group consisting of a straight or branched chain having from 1 to 10 carbon atoms; and (b) R' is an iodinated phenyl linked directly to the ester oxygen or through a lower alkylene group consisting of a straight or branched chain having from 1 to 3 carbon atoms.
Claim 4
Dependent Claim 129 words
The method of claim 2 wherein the pharmaceutically acceptable iodinated phenyl carbonate compound is of the formula ##STR27## wherein: (a) R 1 is a lower alkyl group consisting of a straight or branched chain having from 1 to 10 carbon atoms; (b) R 2 is a lower alkylene chain linking the aromatic ring to the carbonate by 0 to 3 carbon atoms and having attached thereto a constituent selected from the group consisting of hydrogen and alkyl groups with 1 to 4 carbon atoms; (c) X is selected from the group consisting of hydrogen and iodine; and (d) W and Y are each selected from the group consisting of hydrogen, iodine, amine and acetamido when X is iodine, at least W or Y being iodine when X is hydrogen.
Claim 5
Dependent Claim 29 words
The method of claim 3 wherein the iodinated phenyl carbonate compound is capable of elimination by the normal body processes within less than about six weeks following said placing.
Claim 6
Dependent Claim 55 words
The method of claim 3 wherein said X-raying comprises performing a radiographic study of the body cavity, said performing including X-raying the cavity from different angles and over a period of time as the placed amount of iodinated phenyl carbonate moves inside the cavity in order to obtain visualization of the complete inner body cavity.
Claim 7
Dependent Claim 26 words
The method of claim 1 additionally comprising the step of allowing the placed amount of iodinated phenyl carbonate to be eliminated by the normal body processes.
Claim 8
Dependent Claim 13 words
The method of claim 1 wherein said placing comprises injecting through a needle.
Claim 9
Dependent Claim 13 words
The method of claim 1 wherein said placing comprises insuflating through a tube.
Claim 10
Dependent Claim 31 words
The method of claim 7 which additionally includes bringing the iodinated phenyl carbonate to about body temperature prior to said injecting and injecting said compound while at about the body temperature.

References Cited (Backward Citations)

US3235461A Cited
US2348231A Cited
US2386640A Cited
US3178473A Cited
US3676486A Cited
US3883578A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1982-11-26 1983-05-28 1983-11-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1986-11-26 1987-05-28 1987-11-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1990-11-26 1991-05-28 1991-11-27 $7700.00 Window Closed / Lapsed

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