Abstract A method for using iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, to provide radiopaques for various radiography purposes in connection with such techniques as X-ray applications including myelography, salpingography, lymphography and bronchography. The method first comprises selecting a compound generally categorized as a carbonate and having the general formula ##STR1## wherein R represents an alkyl group having from 1 to 10 carbon atoms and R' represents an iodinated phenyl linked directly to the ester oxygen or through an alkyl chain consisting of 1 to 3 carbon atoms. An effective amount of a pharmaceutically acceptable carbonate, as defined herein, is then placed into the subject body cavity and the particular X-ray or other study performed of this area.
A method for visualizing an inner body cavity in an animal comprising: (a) placing an effective amount of a pharmaceutically acceptable iodinated phenyl carbonate compound into a body cavity in an animal; and (b) X-raying the body cavity.
Claim 2
Independent Claim
38 words
A method for visualizing an inner body cavity in an animal comprising: (a) placing an effective amount of a pharmaceutically acceptable iodinated phenyl carbonate compound into a body cavity in an animal; and (b) X-raying the body cavity.
Claim 3
Dependent Claim
73 words
The method of claim 1 wherein the pharmaceutically acceptable iodinated phenyl carbonate compound is of the formula ##STR26## wherein: (a) R is a lower alkyl group consisting of a straight or branched chain having from 1 to 10 carbon atoms; and (b) R' is an iodinated phenyl linked directly to the ester oxygen or through a lower alkylene group consisting of a straight or branched chain having from 1 to 3 carbon atoms.
Claim 4
Dependent Claim
129 words
The method of claim 2 wherein the pharmaceutically acceptable iodinated phenyl carbonate compound is of the formula ##STR27## wherein: (a) R 1 is a lower alkyl group consisting of a straight or branched chain having from 1 to 10 carbon atoms; (b) R 2 is a lower alkylene chain linking the aromatic ring to the carbonate by 0 to 3 carbon atoms and having attached thereto a constituent selected from the group consisting of hydrogen and alkyl groups with 1 to 4 carbon atoms; (c) X is selected from the group consisting of hydrogen and iodine; and (d) W and Y are each selected from the group consisting of hydrogen, iodine, amine and acetamido when X is iodine, at least W or Y being iodine when X is hydrogen.
Claim 5
Dependent Claim
29 words
The method of claim 3 wherein the iodinated phenyl carbonate compound is capable of elimination by the normal body processes within less than about six weeks following said placing.
Claim 6
Dependent Claim
55 words
The method of claim 3 wherein said X-raying comprises performing a radiographic study of the body cavity, said performing including X-raying the cavity from different angles and over a period of time as the placed amount of iodinated phenyl carbonate moves inside the cavity in order to obtain visualization of the complete inner body cavity.
Claim 7
Dependent Claim
26 words
The method of claim 1 additionally comprising the step of allowing the placed amount of iodinated phenyl carbonate to be eliminated by the normal body processes.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein said placing comprises injecting through a needle.
Claim 9
Dependent Claim
13 words
The method of claim 1 wherein said placing comprises insuflating through a tube.
Claim 10
Dependent Claim
31 words
The method of claim 7 which additionally includes bringing the iodinated phenyl carbonate to about body temperature prior to said injecting and injecting said compound while at about the body temperature.