US4193931A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyene compounds
Assignee: Hoffmann La Roche Inc
•
Filing: 1978-04-24
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Granted: 1980-03-18
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Expires: 1998-04-24
Abstract
Abstract Novel 7-(substituted indanyl or naphthyl)-3-methyl-octa-2,4,6-triene derivatives useful as anti-tumor agents are disclosed.
Inventors
- 👤 Peter Loeliger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:30
CPC Classifications
C; C07; C07C; C07C29/00; C07C29/132; C07C29/136; C07C29/143; A; A61; A61P; A61P35/00; C07C33/00; C07C33/38; C07C33/40; C07C33/50; C07C45/00; C07C45/45; C07C45/46; C07C49/00; C07C49/76; C07C49/782; C07C49/792; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/54; C07F9/5456; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/10
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
65 words
A polyene compound of the formula: ##STR14## wherein R 1 and R 2 each are hydrogen, halogen or lower alkoxy; R 3 , R 4 , R 5 and R 6 each are hydrogen or lower alkyl; R 7 is hydroxymethyl, lower alkoxymethyl, lower alkanoyloxymethyl, carboxyl, lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl; and n is 1 or 2 or the alkali metal salts thereof.
Claim 2
Dependent Claim
65 words
A polyene compound of the formula: ##STR14## wherein R 1 and R 2 each are hydrogen, halogen or lower alkoxy; R 3 , R 4 , R 5 and R 6 each are hydrogen or lower alkyl; R 7 is hydroxymethyl, lower alkoxymethyl, lower alkanoyloxymethyl, carboxyl, lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl; and n is 1 or 2 or the alkali metal salts thereof.
Claim 3
Dependent Claim
21 words
The polyene compound of claim 1 wherein R 3 , R 4 , R 5 and R 6 each are hydrogen.
Claim 4
Dependent Claim
18 words
The polyene compound of claim 1 wherein R 1 and R 2 each are hydrogen or lower alkoxy.
Claim 5
Dependent Claim
20 words
The polyene compound of claims 1, 2 or 3 wherein R 7 is lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl.
Claim 6
Dependent Claim
13 words
The compound of claim 1 wherein the compound is all-trans-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 7
Dependent Claim
11 words
The compound of claim 1 wherein the compound is all-trans-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid.
Claim 8
Dependent Claim
12 words
The compound of claim 1 wherein the compound is all-trans-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethylamide.
Claim 9
Dependent Claim
13 words
The compound of claim 1 wherein the compound is all-trans-7-(6-methoxy-1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 10
Dependent Claim
13 words
The compound of claim 1 wherein the compound is all-trans-7-(3,3-dimethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 11
Dependent Claim
14 words
The compound of claim 1 wherein the compound is all trans-7-(7-methoxy-3,3-dimethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 12
Dependent Claim
13 words
The compound of claim 1 wherein the compound is all-trans-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 13
Dependent Claim
13 words
The compound of claim 1 wherein the compound is all-trans-7-(3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 14
Dependent Claim
72 words
A pharmaceutical preparation containing a polyene compound of the formula: ##STR15## wherein R 1 and R 2 each are hydrogen, halogen atom or lower alkoxy; R 3 , R 4 , R 5 and R 6 each are hydrogen or lower alkyl; R 7 is hydroxymethyl, lower alkoxymethyl, lower alkanoyloxymethyl, carboxyl, lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl group; and n is 1 or 2; in association with a compatible pharmaceutical carrier.
Claim 15
Dependent Claim
72 words
A pharmaceutical preparation containing a polyene compound of the formula: ##STR15## wherein R 1 and R 2 each are hydrogen, halogen atom or lower alkoxy; R 3 , R 4 , R 5 and R 6 each are hydrogen or lower alkyl; R 7 is hydroxymethyl, lower alkoxymethyl, lower alkanoyloxymethyl, carboxyl, lower alkoxycarbonyl, mono(lower alkyl)carbamoyl or di(lower alkyl)carbamoyl group; and n is 1 or 2; in association with a compatible pharmaceutical carrier.
Claim 16
Dependent Claim
15 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 17
Dependent Claim
13 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid.
Claim 18
Dependent Claim
14 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethylamide.
Claim 19
Dependent Claim
15 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(6-methoxy-1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 20
Dependent Claim
15 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(3,3-dimethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 21
Dependent Claim
15 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(7-methoxy-3,3-dimethyl-5-indanyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 22
Dependent Claim
15 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
Claim 23
Dependent Claim
15 words
The pharmaceutical preparation of claim 13 wherein said polyene compound is all-trans-7-(3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-3-methyl-octa-2,4,6-trien-1-oic acid ethyl ester.
References Cited (Backward Citations)
US3781314A
Cited
US3957836A
Cited
US3984440A
Cited
US3931257A
Cited
DE2542600A1
Cited
US4054589A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-18 | 1983-09-17 | 1984-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-18 | 1987-09-17 | 1988-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-18 | 1991-09-17 | 1992-03-18 | $7700.00 | Window Closed / Lapsed |