Patent US4206200A successfully refreshed from Google Patents.
US4206200A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilizer for polysaccharides
Assignee: GSK Vaccines GmbH
•
Filing: 1978-10-25
•
Granted: 1980-06-03
•
Expires: 1998-10-25
Abstract
Abstract For improving the stability of menningococcal polysaccharides in aqueous solution, lactose is completely or partially replaced by another compound which forms a hydrate and can be reversibly dehydrated under the conditions of lyophilization. The mixture may then be dried and/or processed to a vaccine.
Inventors
- 👤 Gerhard Guthohrlein
- 👤 Torsten B. Helting
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:10
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K39/00; A61K39/02; A61K39/095; A61K47/00; A61K47/06; A61K47/26; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
93 words
In a process for improving the stabilization of a Neisseria Meningitidis polysaccharide by the addition of lactose, the improvement comprising adding to an aqueous solution of Neisseria meningitidis polysaccharide, instead of the total amount of a part of lactose, at least 0.3 mg per 100 μg of Neisseria meningitidis polysaccharide of at least one compound selected from the group consisting of sucrose, raffinose, glucose, trehalose, glycerophosphate and glutaminate as a stabilizer to increase the stabilization of Neisseria meningitidis and which stabilizer forms a hydrate and can be reversibly dehydrated under conditions of lyophilization.
Claim 2
Dependent Claim
93 words
In a process for improving the stabilization of a Neisseria Meningitidis polysaccharide by the addition of lactose, the improvement comprising adding to an aqueous solution of Neisseria meningitidis polysaccharide, instead of the total amount of a part of lactose, at least 0.3 mg per 100 μg of Neisseria meningitidis polysaccharide of at least one compound selected from the group consisting of sucrose, raffinose, glucose, trehalose, glycerophosphate and glutaminate as a stabilizer to increase the stabilization of Neisseria meningitidis and which stabilizer forms a hydrate and can be reversibly dehydrated under conditions of lyophilization.
Claim 3
Dependent Claim
22 words
The process of claim 1 wherein 1 to 100 mg per 100 μg of polysaccharide of at least one stabilizer is added.
Claim 4
Dependent Claim
21 words
In the process of claim 1 wherein an aqueous reconstituted solution of freeze-dried Neisseria meningitidis polysaccharide is suitable for parenteral administration.
Claim 5
Dependent Claim
38 words
A Neisseria meningitidis vaccine comprising an aqueous solution of Neisseria meningitidis polysaccharide and at least 0.3 mg per 100 μg of polysaccharide of a stabilizer selected from the group consisting of sucrose, raffinose, glucose, trehalose, glycerophosphate and glutaminate.
Claim 6
Dependent Claim
38 words
A Neisseria meningitidis vaccine comprising an aqueous solution of Neisseria meningitidis polysaccharide and at least 0.3 mg per 100 μg of polysaccharide of a stabilizer selected from the group consisting of sucrose, raffinose, glucose, trehalose, glycerophosphate and glutaminate.
Claim 7
Dependent Claim
16 words
A vaccine according to claim 4 wherein the Neisseria meningitidis polysaccharide is in admixture with lactose.
Claim 8
Dependent Claim
25 words
A vaccine according to claims 4 or 5 wherein the stabilizer is present in an amount of 5 to 20 mg/ml of the vaccine solution.
Claim 9
Independent Claim
46 words
A method for stabilizing a Neisseria meningitidis polysaccharide which comprises adding at least 0.3 mg per 100 μg of Neisseria meningitidis of a stabilizer selected from the group consisting of sucrose, raffinose, glucose, trehalose, glycerophosphate and glutaminate to an aqueous solution of a Neisseria meningitidis polysaccharide.
Claim 10
Independent Claim
46 words
A method for stabilizing a Neisseria meningitidis polysaccharide which comprises adding at least 0.3 mg per 100 μg of Neisseria meningitidis of a stabilizer selected from the group consisting of sucrose, raffinose, glucose, trehalose, glycerophosphate and glutaminate to an aqueous solution of a Neisseria meningitidis polysaccharide.
References Cited (Backward Citations)
US2908614A
Cited
US3135663A
Cited
US3322632A
Cited
US3567585A
Cited
US3532790A
Cited
US3608066A
Cited
US3743720A
Cited
US3577527A
Cited
US3599150A
Cited
US3636192A
Cited
US3859434A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-06-03 | 1983-12-03 | 1984-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-06-03 | 1987-12-03 | 1988-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-06-03 | 1991-12-03 | 1992-06-03 | $7700.00 | Window Closed / Lapsed |